Cell Biology

A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

1. Damien Laporte
2. Aurelie Massoni-Laporte
3. Charles Lefranc
4. Jim Dompierre
5. David Mauboules
6. Emmanuel T Nsamba
7. Anne Royou
8. Lihi Gal
9. Maya Schuldiner
10. Mohan L Gupta
11. Isabelle Sagot

• Curated by eLife

  eLife assessment

  This work presents important insights regarding the mechanism underlying the assembly, maintenance, and disassembly of a very stable microtubule-based structure, termed quiescent-cell nuclear microtubule (Q-nMT) bundle, which is formed in quiescent yeast cells to ensure cell survival and viability. This insight will help to elucidate how very stable microtubules can exist alongside very dynamic microtubules, which is still poorly understood. While the experimental support is overall solid, additional analyses using state-of-the-art methodology would further strengthen some of the claims.

Reviewed by eLife

c-Src induced vascular malformations require localised matrix degradation at focal adhesions

1. Patricia Essebier
2. Lilian Schimmel
3. Teodor Yordanov
4. Mikaela Keyser
5. Alexander Yu
6. Ivar Noordstra
7. Brittany Hill
8. Alpha S. Yap
9. Samantha J. Stehbens
10. Anne K. Lagendijk
11. Emma J. Gordon

Reviewed by Review Commons

Centriolar satellites are sites of translation of centrosomal and ciliary proteins

1. Claudia Pachinger
2. Jeroen Dobbelaere
3. Cornelia Rumpf-Kienzl
4. Shiviya Raina
5. Júlia Garcia-Baucells
6. Marina Sarantseva
7. Andrea Brauneis
8. Alexander Dammermann

Reviewed by Arcadia Science

Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

1. Preksha Gaur
2. Yesheswini Rajendran
3. Bhagyashree Srivastava
4. Manasvini Markandey
5. Vered Fishbain-Yoskovitz
6. Gayatree Mohapatra
7. Aamir Suhail
8. Shikha Chaudhary
9. Shaifali Tyagi
10. Subhash Chandra Yadav
11. Amit Kumar Pandey
12. Yifat Merbl
13. Avinash Bajaj
14. Vineet Ahuja
15. Chittur Srikanth

• Curated by eLife

  eLife assessment

  This is an important study for understanding the pathogenesis of ulcerative colitis. It convincingly demonstrates reduced levels of the vesicular trafficking protein Rab7 in ulcerative colitis and Crohn's disease, leading to altered levels of calcium-activated chloride channel regulator 1 (CLCA1) and subsequent mucin dysregulation, highlighting Rab7's significance in gut homeostasis maintenance. The manuscript advances the field as it provides insights into a novel regulatory pathway implicated in ulcerative colitis, potentially paving the way for the development of targeted therapeutic interventions.

Reviewed by eLife

Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

1. Fabian Link
2. Alyssa Borges
3. Oliver Karo
4. Marvin Jungblut
5. Thomas Müller
6. Elisabeth Meyer-Natus
7. Timothy Krüger
8. Stefan Sachs
9. Nicola G Jones
10. Mary Morphew
11. Markus Sauer
12. Christian Stigloher
13. J Richard McIntosh
14. Markus Engstler

• Curated by eLife

  eLife assessment

  This important study combines a range of advanced ultrastructural imaging approaches to define the unusual endosomal system of African trypanosomes. Compelling images reveal that, unlike a conventional set of compartments, the endosome in these protists forms a continuous membrane system with functionally distinct subdomains, as defined by canonical markers for early, late, and recycling endosomes. The findings compellingly support that the endocytic system in bloodstream stages has adapted to support remarkably high rates of membrane turnover necessary for immune complex removal and survival in the blood. This research is particularly relevant to those investigating infectious diseases

Reviewed by eLife

The CUL4-DDB1-DCAF1 E3 ubiquitin ligase complex regulates PLK4 protein levels to prevent premature centriole duplication

1. Josina Grossmann
2. Anne-Sophie Kratz
3. Alina Kordonsky
4. Gali Prag
5. Ingrid Hoffmann

Reviewed by Review Commons

Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis

1. Kentaro Homan
2. Tomohiro Onodera
3. Hisatoshi Hanamatsu
4. Jun-ichi Furukawa
5. Daisuke Momma
6. Masatake Matsuoka
7. Norimasa Iwasaki

• Curated by eLife

  eLife assessment

  This valuable study sheds light on the pivotal role of alterations in chondrocyte glycan metabolism in two contexts: The onset of cartilage degeneration and early onset of osteoarthritis (OA). The action is through hypertrophic differentiation of chondrocytes, a finding that provides insights into the identification of nascent markers for early-stage OA. The evidence supporting the claims is solid, with the authors clearly demonstrating the role of articular cartilage corefucosylation in the development of OA. The authors' inferences would be further enhanced through future experiments aimed at analyzing the mechanisms underlying the changes in glycometabolism in cartilage.

Reviewed by eLife

Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

1. Atikul Islam
2. Yu-Chun Chang
3. Xiao-Chi Chen
4. Chia-Wei Weng
5. Chien-Yu Chen
6. Che-Wei Wang
7. Mu-Kuan Chen
8. Alexander S Tikhomirov
9. Andrey E Shchekotikhin
10. Pin Ju Chueh

• Curated by eLife

  eLife assessment

  This useful study reports that a water-soluble analog of heliomycin, 4-dmH, induces protein degradation of not only SirT1 but also tNOX, unlike heliomycin, which induces degradation of SirT1 but not tNOX, a difference that could in principle explain why 4-dmH induces apoptosis while heliomycin induces autophagy. The presented data provide solid support for the authors' conclusions.

Reviewed by eLife

Neutral evolution of snoRNA Host Gene long non-coding RNA affects cell fate control

1. Matteo Vietri Rudan
2. Kalle H. Sipilä
3. Christina Philippeos
4. Clarisse Gânier
5. Victor A. Negri
6. Fiona M. Watt

Reviewed by Review Commons

FAM134B regulates ER-to-lysosome-associated degradation of misfolded proteins upon pharmacologic or genetic inactivation of ER-associated degradation

1. Elisa Fasana
2. Ilaria Fregno
3. Carmela Galli
4. Maurizio Molinari

Reviewed by Review Commons