Cell Biology

Profiling the physiological impact of aberrant folded-state protein filamentation in cells

1. Tal Levin
2. Hector Garcia-Seisdedos
3. Arseniy Lobov
4. Matthias Wojtynek
5. Alexander Alexandrov
6. Ghil Jona
7. Dikla Levi
8. Ohad Medalia
9. D. Emmanuel Levy

Reviewed by Review Commons

A novel approach to tagging tubulin reveals microtubule assembly dynamics of the axoneme in Trypanosoma brucei

1. Daniel Abbühl
2. Martina Pružincová
3. Luděk Štěpánek
4. Eleonore Bouscasse
5. Rita Azevedo
6. Mariette Matondo
7. Vladimir Varga
8. Serge Bonnefoy
9. Philippe Bastin

Reviewed by Review Commons

Image Correlation Spectroscopy is a Robust Tool to Quantify Cellular DNA Damage Response

1. Angelica A Gopal
2. Bianca Fernandez
3. Paul W Wiseman
4. J Matthew Dubach

• Curated by eLife

  eLife Assessment

  This valuable paper shows image correlation spectroscopy (ICS) as a new tool to analyze the clustering of proteins involved in DNA damage response (DDR). The convincing evidence presented demonstrates that ICS is more sensitive than traditional foci counting. This new method provides an alternative tool to quantify immunostained foci for researchers in the fields of DDR and cell biology.

Reviewed by eLife

Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing

1. Yunpei Zhang
2. Pingting Wang
3. Lingling Neng
4. Kushal Sharma
5. Allan Kachelmeier
6. Xiaorui Shi

• Curated by eLife

  eLife Assessment

  This study exploring the role of TRPV1 signaling in recruiting macrophages and promoting angiogenesis during tympanic membrane wound healing presents useful findings. However, the strength of evidence supporting the central claims is incomplete, as the mechanistic links between TRPV1 activation and immune cell recruitment remain largely correlative and rely heavily on previously published datasets without sufficient functional validation. The work will be of interest to researchers studying wound healing and sensory-immune interactions, though substantial revisions are needed to support its broader significance.

Reviewed by eLife

Dual regulation of the unfolded protein response by IGF2BP3 during ER stress

1. Aleksandra S Anisimova
2. Harald Hornegger
3. Irmgard Fischer
4. Gijs A Versteeg
5. Stefan L Ameres
6. G Elif Karagöz

Reviewed by PREreview

Random UV Mutagenesis for the production of Chlorella vulgaris mutants with low chlorophyll content for the food industry

1. Ivan N. Ivanov
2. Jiří Kopecký
3. Karolína Štěrbová
4. Pavel Hrouzek
5. Martin Lukeš
6. Kateřina Bišová
7. Setyo Budi Kurniawan

Reviewed by Arcadia Science