Cell Biology

  1. A single factor for safer cellular rejuvenation

    1. Lucas Paulo de Lima Camillo
    2. Rihab Gam
    3. Katsiaryna Maskalenka
    4. Francis J. A. LeBlanc
    5. Gustavo Antonio Urrutia
    6. Gabriel M. Mejia
    7. Henry E. Miller
    8. Christopher P. Wardlaw
    9. Adam Pickles
    10. Laura Everton
    11. Ringaile Zaksauskaite
    12. Rejina B. Khan
    13. Andreas Welsh
    14. Samira Gambo
    15. Stephany Gallardo
    16. Zoryana Oliynyk
    17. Sagar S. Varankar
    18. Alexander E. Epstein
    19. Adam Bendall
    20. Jonathan Mowatt
    21. Daniel Ives
    22. Brendan M. Swain

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis

    1. Meagan J Makarczyk
    2. Yiqian Zhang
    3. Alyssa Aguglia
    4. Olivia Bartholomew
    5. Sophie Hines
    6. Kate Li
    7. Suyash Sinkar
    8. Silvia Liu
    9. Craig Duvall
    10. Hang Lin

    • Curated by eLife

      eLife Assessment

      This study presents an important finding on the role of GATA4 in aging- and OA-associated cartilage pathology. The conclusions are well supported by compelling in vitro and in vivo evidence. This work will be of broad interest to both cell biologists and orthopedic clinicians.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  3. PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

    1. Jimena Druker
    2. Hao Jiang
    3. Dilem Shakir
    4. Fraser Child
    5. Vanesa Alvarez
    6. Melpomeni Platani
    7. Andrea Corno
    8. Constance Alabert
    9. Adrian T Saurin
    10. Jason R Swedlow
    11. Sonia Rocha
    12. Angus I Lamond

    • Curated by eLife

      eLife Assessment

      This compelling work describes how the cell cycle-regulating phosphatase subunit, RepoMan, is regulated by the oxygen-dependent, metabolite-sensing hydroxylase PHD1. The characterisation of how proline hydroxylation alters signalling at the molecular and cellular level provides important evidence to enhance our understanding of how 2-oxoglutarate-dependent dioxygenases influence the cell cycle and mitosis.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Nuclear disruption as a mechanism of the chemotherapeutic drug paclitaxel in interphase

    1. Thomas Hale
    2. Victoria L Hale
    3. Piotr Kolata
    4. Ália dos Santos
    5. Matteo Allegretti

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling

    1. Fansen Meng
    2. Jong Hwan Kim
    3. Chang-Ru Tsai
    4. Jeffrey D Steimle
    5. Jun Wang
    6. Yufeng Shi
    7. Rich G Li
    8. Bing Xie
    9. Vaibhav Deshmukh
    10. Shijie Liu
    11. Xiao Li
    12. James F Martin

    • Curated by eLife

      eLife Assessment

      This important study elucidates the molecular function of the SARS-CoV-2 helicase NSP13, which inhibits the transcriptional activity of the YAP/TEAD complex in vitro and in vivo. The evidence supporting the authors' claims is compelling, based on cell biological assays and multi-omic studies. This work contributes to the understanding of the new regulatory mechanism of YAP/TEAD after SARS-CoV-2 infection and will be of interest to researchers investigating COVID-19 infection and the Hippo-YAP signaling pathway.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  6. Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

    1. Maria Llamazares Prada
    2. Uwe Schwartz
    3. Darius F. Pease
    4. Stephanie T. Pohl
    5. Deborah Ackesson
    6. Renjiao Li
    7. Annika Behrendt
    8. Raluca Tamas
    9. Mandy Richter
    10. Thomas Muley
    11. Joschka Hey
    12. Elisa Espinet
    13. Claus P. Heußel
    14. Arne Warth
    15. Mark Schneider
    16. Hauke Winter
    17. Felix Herth
    18. Charles D Imbusch
    19. Benedikt Brors
    20. Vladimir Benes
    21. David Wyatt
    22. Tomasz P. Jurkowski
    23. Heiko F. Stahl
    24. Christoph Plass
    25. Renata Z. Jurkowska

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  7. CCDC32 stabilizes clathrin-coated pits and drives their invagination

    1. Ziyan Yang
    2. Changsong Yang
    3. Zheng Huang
    4. Peiliu Xu
    5. Yueping Li
    6. Lu Han
    7. Linyuan Peng
    8. Xiangying Wei
    9. John Pak
    10. Tatyana Svitkina
    11. Sandra L Schmid
    12. Zhiming Chen

    • Curated by eLife

      eLife Assessment

      The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity

  8. Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

    1. Dong Luo
    2. Jing Zheng
    3. Shuning Lv
    4. Ren Sheng
    5. Maorong Chen
    6. Xi He
    7. Xinjun Zhang

    • Curated by eLife

      eLife Assessment

      This study presents important findings demonstrating that the internalization and degradation of FZD5 and FZD8, two of the ten Frizzled proteins, are WNT dependent and do not involve DVL. The evidence supporting the claims of the authors is convincing. This research will be of interest to biologists specializing in Wnt signaling, cancer, and regenerative medicine.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  9. Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study

    1. Xiao Shi
    2. Michelle C Palumbo
    3. Sheila Benware
    4. Jack Wiedrick
    5. Sheila Markwardt
    6. Aaron Janowsky

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings by demonstrating that specific GPCR subtypes induce distinct extracellular vesicle miRNA signatures, highlighting a potential novel mechanism for intercellular communication with implications for receptor pharmacology within the field. The data is compelling, however, more evidence is needed to determine whether the distinct extracellular vesicle miRNA signatures result from GPCR-dependent miRNA expression or GPCR-dependent incorporation of miRNAs into extracellular vesicles.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. RNA triggers chronic stress during neuronal aging

    1. Kevin Rhine
    2. Elle Epstein
    3. Natasha M. Carlson
    4. Xuezhen Ge
    5. Orel Mizrahi
    6. Anika Kamat
    7. Anita Hermann
    8. William R. Brothers
    9. John Ravits
    10. Eric J. Bennett
    11. Gülçin Pekkurnaz
    12. Gene W. Yeo

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity
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