Cell Biology

BICD2 is a centriolar protein that controls mother-daughter centriole engagement and the licensing of duplication

1. Lídia Montes-Ruiz
2. Núria Gallisà-Suñé
3. Laura Regué
4. Lorena Fernández-de-Larrea
5. Joan Roig

Reviewed by Review Commons

Localized disruption of the presynaptic endoplasmic reticulum in Atlastin mutants

1. Mónica C. Quiñones-Frías
2. Dina M. Ocken
3. Avital A. Rodal

Reviewed by Review Commons

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

1. Jessica Tittelmeier
2. Carl Alexander Sandhof
3. Nicole Martin
4. Deike El-Kabarity
5. Soki-Bradel Ngonza-Nito
6. Ronald Melki
7. Carmen Nussbaum-Krammer

• Curated by eLife

  eLife Assessment

  This important study addresses the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau pathology in Caenorhabditis elegans and human cell culture models. The findings are convincing, and the proposed mechanisms are conceivable. The experimental evidence supports the conclusions of the study. The work will be of broad interest to cell biologists and biologists working on Alzheimer's disease and related proteinopathies.

Reviewed by eLife