Cell Biology

GMCL1 Controls 53BP1 Stability and Modulates Taxane Sensitivity

1. Yuki Kito
2. Tania J González-Robles
3. Sharon Kaisari
4. Juhee Pae
5. Sheena Faye Garcia
6. Juliana Ortiz-Pacheco
7. Beatrix Ueberheide
8. Antonio Marzio
9. Gergely Rona
10. Michele Pagano

• Curated by eLife

  eLife Assessment

  This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study proposes a novel mechanism by which cancer cells evade the mitotic surveillance pathway through GMCL1-mediated degradation of 53BP1, leading to reduced p53 activation and paclitaxel resistance. These data are the most useful aspect of the study, but the data supporting the authors' conclusions as to the clinical relevance of the study are inadequate. The authors have not taken relevant data about the clinical mechanism of taxanes into account.

Reviewed by eLife

Cell type specific allometry controls sex-differences in Drosophila body size

1. Soumitra Pal
2. Jerome Avellaneda
3. Celena M. Cherian
4. Puja Biswas
5. Georg Vogler
6. Elizabeth J. Rideout
7. Frank Schnorrer
8. Teresa M. Przytycka
9. Brian Oliver

Reviewed by Review Commons

CROP2, a Retriever-PROPPIN Complex Mediating Protein Export from Endosomes to the Plasma Membrane

1. Maria Giovanna De Leo
2. Andreas Mayer

• Curated by eLife

  eLife Assessment

  The authors present evidence for a WIPI2-Retriever complex (termed CROP2) that couples cargo selection to carrier fission at endosomes. CROP2 appears to function analogously to the previously described CROP1 complex, formed by WIPI1 and Retromer, with which it shares structural similarities. They provide convincing evidence that CROP1 and CROP2 regulate the trafficking of distinct subsets of cargoes; however, the cellular evidence for the existence of these distinct complexes remains incomplete. Overall, the findings are important and expand our understanding of how cargo selection by Retriever and Retromer is orchestrated at endosomes.

Reviewed by eLife

Disruption of Iron Metabolism Resulting from Dmt1/Slc11A2 Deficiency Compromises Notch Protein Degradation and Transcriptional Activation

1. Rui Zhang
2. Somaieh Ahmadian
3. Jolanda Piepers
4. Florian Bock
5. Tom Keulers
6. Marc A. Vooijs

Reviewed by PREreview

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

1. Mohamad Youness
2. Onne A.H.O. Ronda
3. Ankit Pradhan
4. Filip Rega
5. Karin R. Sipido
6. H. Llewelyn Roderick

Reviewed by preLights

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity

1. Emma C. Murray
2. Gillian M. Hodge
3. Khanh Pham
4. Leighton S. Lee
5. Cameron A.R. Mitchell
6. Yongho Bae
7. Andrew T. Lombardo

Reviewed by Review Commons

Centrosome Loss in Embryonic Development Disrupts Axonal Pathfinding and Muscle Integrity

1. Beatriz González
2. Júlia Sellés-Altés
3. Jèrica Pla-Parron
4. Judith Castro-Ribera
5. Sofia J. Araújo

Reviewed by Review Commons

MAP7 directs apical cytoskeletal remodeling to establish Sertoli cell polarity and support germ cell development

1. Koji Kikuchi
2. Toshihiko Fujimori
3. Mami Nakagawa
4. Keisuke Ohta
5. Ryuki Shimada
6. Sayoko Fujimura
7. Kei-ichiro Yasunaga
8. Shingo Usuki
9. Naoki Tani
10. Akira Nakamura
11. Kimi Araki
12. Kei-ichiro Ishiguro

Reviewed by Review Commons

The Rhizarian amoeba Filoreta ramosa develops a neuron-like arborized network using conserved cytoskeletal mechanisms

1. Sarah L. Guest
2. Scott C. Dawson

Reviewed by Arcadia Science

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulation

1. Lu Xiong
2. Elisa Lazzari
3. Sabrina Pacor
4. Simeone Dal Monego
5. Erica Piovesan
6. Danilo Licastro
7. Germana Meroni

Reviewed by Review Commons