Cell Biology

  1. Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures

    1. Ameen A. Salahudeen
    2. Shannon S. Choi
    3. Arjun Rustagi
    4. Junjie Zhu
    5. Sean M. de la O
    6. Ryan A. Flynn
    7. Mar Margalef-Català
    8. António J. M. Santos
    9. Jihang Ju
    10. Arpit Batish
    11. Vincent van Unen
    12. Tatsuya Usui
    13. Grace X.Y. Zheng
    14. Caitlin E. Edwards
    15. Lisa E. Wagar
    16. Vincent Luca
    17. Benedict Anchang
    18. Monica Nagendran
    19. Khanh Nguyen
    20. Daniel J. Hart
    21. Jessica M. Terry
    22. Phillip Belgrader
    23. Solongo B. Ziraldo
    24. Tarjei S. Mikkelsen
    25. Pehr B. Harbury
    26. Jeffrey S. Glenn
    27. K. Christopher Garcia
    28. Mark M. Davis
    29. Ralph S. Baric
    30. Chiara Sabatti
    31. Manuel R. Amieva
    32. Catherine A. Blish
    33. Tushar J. Desai
    34. Calvin J. Kuo

    Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

    8 evaluationsAppears in 3 listsLatest version Latest activity

  2. Unconventional components complement the cryptic kinetochore of the ciliate Tetrahymena thermophila

    1. Emine I. Ali
    2. Maximilian W. D. Raas
    3. Laura E. van Rooijen
    4. Paula Sobrevals Alcaraz
    5. Harmjan R. Vos
    6. Eelco C. Tromer
    7. Berend Snel
    8. Geert J.P.L. Kops

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    1. Ellen Späth
    2. Svenja C Schüler
    3. Ivonne Heinze
    4. Therese Dau
    5. Alberto Minetti
    6. Maleen Hofmann
    7. Katja Hönzke
    8. Julia von Maltzahn
    9. Alessandro Ori

    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into the regulation of myogenic differentiation by identifying Leiomodin 1 as a modulator of proteome dynamics during myogenic differentiation. The combination of quantitative proteomics with functional perturbation experiments offers solid evidence supporting the idea that SIRT1 influences perturbations of myogenic differentiation upon LMOD1 inactivation. These findings advance our understanding of muscle differentiation and will be of interest to researchers studying muscle development and related pathologies

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  4. The insulin / IGF axis is critically important controlling gene transcription in the podocyte

    1. Jennifer A Hurcombe
    2. Lusyan Dayalan
    3. Fern Barrington
    4. Frédéric Burdet
    5. Lan Ni
    6. Joseph T Coward
    7. Mark Ibberson
    8. Paul T Brinkkoetter
    9. Martin Holzenberger
    10. Aaron Jeffries
    11. Sebastian Oltean
    12. Gavin I Welsh
    13. Richard JM Coward

    • Curated by eLife

      eLife Assessment

      This valuable study used genetic and pharmacological manipulations of insulin/IGF signaling in renal glomerular podocytes to address the role of insulin/IGF axis in podocytes. Solid data are presented to demonstrate that co-inhibition of insulin/IGF signaling in podocytes led to aberrant splicing of mRNAs, which could contribute to the loss of podocytes in vitro and in vivo in mice. As it stands, the study lacks the assessment of developmental phenotype of podocytes in the mouse model.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  5. Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    1. Qi Zhang
    2. Yunfeng Wang
    3. Xueli Fu
    4. Ziguang Wang
    5. Yang Zhang
    6. Lizhong Yan
    7. Yuejia Wang
    8. Muhan Yang
    9. Dongze Song
    10. Ruixing Zhang
    11. Hongru Zhang
    12. Shian Wu
    13. Shaowei Zhao

    • Curated by eLife

      eLife Assessment

      This valuable study examines the role of E2 ubiquitin enzyme, Uev1a in tissue resistance to oncogenic RasV12 in Drosophila melanogaster polyploid germline cells and human cancer cell lines. The solid evidence suggests that Uev1a works with the E3 ligase APC/C to degrade Cyclin A. This work would be of interest to researchers in germline biology and cancer.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  6. Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation

    1. Jingang Cui
    2. Zhiyu Fan
    3. Suoqi Ding
    4. Jiazhen Zhang
    5. Huihong Shen
    6. Syeda Armana Zaidi
    7. Yongsheng Ding

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the role of KLF6 in in vitro endothelial cells exposed to altered (high or low) shear stress with a customized microfluidic device to investigate mechanisms of atherosclerosis. The finding that altered shear stress results in endothelial cell ferroptosis through reduced expression of KLF6 is compelling and adds a new layer of complexity to the pathogenesis of atherosclerotic plaques. However, more detailed characterization of ferroptosis is needed.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  7. LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload

    1. Andres Goldman
    2. Mai Nguyen
    3. Joel Lanoix
    4. Ahmed Fahmy
    5. Yong Zhong Xu
    6. Erwin Schurr
    7. Pierre Thibault
    8. Michel Desjardins
    9. Heidi McBride

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Human receptive endometrial assembloid for deciphering the implantation window

    1. Yu Zhang
    2. Rusong Zhao
    3. Chaoyan Yang
    4. Jinzhu Song
    5. Peishu Liu
    6. Yan Li
    7. Boyang Liu
    8. Tao Li
    9. Changjian Yin
    10. Minghui Lu
    11. Zhenzhen Hou
    12. Chuanxin Zhang
    13. Zi-Jiang Chen
    14. Keliang Wu
    15. Han Zhao

    • Curated by eLife

      eLife Assessment

      This important study reports an endometrial organoid culture system mimicking the window of implantation. The evidence supporting the conclusion drawn is convincing. The data will be of interest to embryologists and investigators working on reproductive biology and medicine.

    Reviewed by eLife

    14 evaluationsAppears in 1 listLatest version Latest activity

  9. A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

    1. Anna Demarinis
    2. Sara Esmaeili
    3. Crystall M. D. Swarbrick
    4. Simone Ranno
    5. Silvia Pavan
    6. Jade K. Forwood
    7. Brian P. McSharry
    8. Martin Pal
    9. Enzo Di Iorio
    10. Gualtiero Alvisi

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

    1. Stefano Sellitto
    2. Davide Caredio
    3. Matteo Bimbati
    4. Giovanni Mariutti
    5. Martina Cerisoli
    6. Lukas Frick
    7. Vangelis Bouris
    8. Carlos Omar Oueslati Morales
    9. Dalila Laura Vena
    10. Sandesh Neupane
    11. Federico Baroni
    12. Kathi Ging
    13. Jiang-An Yin
    14. Elena De Cecco
    15. Andrea Armani
    16. Adriano Aguzzi

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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