Cell Biology

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulation

1. Lu Xiong
2. Elisa Lazzari
3. Sabrina Pacor
4. Simeone Dal Monego
5. Erica Piovesan
6. Danilo Licastro
7. Germana Meroni

Reviewed by Review Commons

Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding

1. Marion F Marchand
2. Noémie Brassard-Jollive
3. Claire Leclech
4. Jorge Barrasa-Fano
5. Yoann Atlas
6. Claudia Umana-Diaz
7. Apeksha Shapeti
8. Corinne Ardidie-Robouant
9. Tristan Piolot
10. Sabrina Martin
11. Philippe Mailly
12. Christophe Guilluy
13. Abdul I Bakarat
14. Catherine Monnot
15. Hans Van Oosterwyck
16. Stéphane Germain
17. Laurent Muller

• Curated by eLife

  eLife Assessment

  This study presents important findings describing the early assembly of vascular basement membrane and how vascular cells switch from responding to cues provided by the external environment to those provided by self-assembled basement membrane. The evidence supporting the claims of the authors is convincing, with state-of-the-art microscopy and several different culture conditions examined. The work will be of interest to cell biologists studying the ECM, vascular development, as well as medical scientists focused on diseases that depend on vascular growth.

Reviewed by eLife

Persistent contacts between Climp63 and microtubules cause mitotic defects and nuclear fragmentation

1. Jelmi uit de Bos
2. Ulrike Kutay

• Curated by eLife

  eLife Assessment

  This important study reveals that mitotic release of an ER-microtubule tether is critical for normal mitotic progression. Manipulating CLIMP63 phosphorylation, the authors provide convincing evidence that persistent microtubule-ER contacts activate the spindle assembly checkpoint and, if mitosis is forced to proceed, drive severe micronucleation. While the study provides new mechanistic insights, some evidence is indirect, and additional experiments would further refine the model.

Reviewed by eLife

Intraflagellar transport-20 mediates the ciliary membrane trafficking of channelrhodopsin in Chlamydomonas reinhardtii

1. Alka Kumari
2. Shilpa Mohanty
3. Snigdha Samanta
4. Suneel Kateriya

Reviewed by Arcadia Science

Stress granules and protein aggregates reveal intracellular resource competition

1. Hannah E. Buchholz
2. Sean A. Martin
3. Jane E. Dorweiler
4. Derek C. Prosser
5. Emily M. Sontag
6. Anita L. Manogaran

Reviewed by Arcadia Science