Cell Biology

NudC moonlights in ribosome biogenesis and homeostasis in Drosophila melanogaster polyploid cells

1. Duoduo Shi
2. Yuko Shimada-Niwa
3. Naoki Okamoto
4. Akira Nakamura
5. Yuya Ohhara
6. Wei Sun
7. Ryusuke Niwa

Reviewed by Review Commons

Ciliary and non-ciliary functions of CEP104 in Xenopus

1. Panagiota Louka
2. Louiza Potamiti
3. Mihalis I. Panayiotidis
4. Paris Skourides

Reviewed by Review Commons

A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

1. Yury S Bykov
2. Solene Zuttion
3. Dunya Edilbi
4. Marina Polozova
5. Johanna Arnold
6. Sergey Malitsky
7. Maxim Itkin
8. Bruno Senger
9. Ofir Klein
10. Yeynit Asraf
11. Hadar Meyer
12. Hubert D Becker
13. Roza Kucharczyk
14. Maya Schuldiner

• Curated by eLife

  eLife Assessment

  This study represents a valuable addition to the catalog of mitochondrial proteins. With the use of methodology based on the bi-genomic split-GFP technology, the authors generate convincing data, including dually localized proteins and topological information, under various growth conditions in yeast. The study represents a key basis for further functional and/or mechanistic studies on mitochondrial protein biogenesis.

Reviewed by eLife

Apelin-13 alleviate inflammatory reaction of ischemia reperfusion in rat kidney transplantation via NF-kappa B signaling pathway

1. Irene Capelli
2. Valeria Aiello
3. Lorenzo Gasperoni
4. Gaetano La Manna

Reviewed by PREreview

HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton

1. Olivier Mercey
2. Luc Reymond
3. Florent Lemaître
4. Isabelle Mean
5. Marine H. Laporte
6. Marine Olivetta
7. Karin Sadoul
8. Omaya Dudin
9. Virginie Hamel
10. Paul Guichard

Reviewed by preLights

Condensin II collaborates with cohesin to establish and maintain interphase chromosome territories

1. Takao Ono
2. Masatoshi Takagi
3. Hideyuki Tanabe
4. Tomoko Fujita
5. Noriko Saitoh
6. Akatsuki Kimura
7. Tatsuya Hirano

Reviewed by Review Commons

The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis

1. Asaad A Al-Adlaan
2. Bryson Cook
3. Nazar J Hussein
4. Fatima A Jaber
5. Trinity Kronk
6. Ernesto Solorzano Z
7. Salvatore Frangiamore
8. Hope C Ball
9. Fayez F Safadi

• Curated by eLife

  eLife Assessment

  This study demonstrates the cartilage-protective effects of osteoactivin in inflammatory experimental models. The work offers valuable insights advancing current knowledge regarding regulation of joint inflammation and tissue degeneration. The evidence provided is compelling and suggests that osteoactivin may serve as a promising therapeutic target for inflammatory joint diseases.

Reviewed by eLife

Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

1. Samuel Bru
2. Lydie Michaillat Mayer
3. Geun-Don Kim
4. Danye Qiu
5. Henning J Jessen
6. Andreas Mayer

• Curated by eLife

  eLife Assessment

  This study provides fundamental insights into eukaryotic phosphate homeostasis by demonstrating how yeast vacuoles dynamically regulate cytosolic phosphate levels. The conclusions are convincing, supported by an elegant combination of in vitro assays and in vivo measurements. This study will be of interest to cell biologists, particularly for those who are working in the field of phosphate metabolism.

Reviewed by eLife

Labeling of Nascent RNA in C. elegans Intestine

1. Omid Gholamalamdari
2. Stephanie C. Weber

Reviewed by Arcadia Science

SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

1. Martina Oravcová
2. Minghua Nie
3. Takanori Otomo
4. Michael N Boddy

• Curated by eLife

  eLife Assessment

  This Research Advance manuscript further elucidates the roles of SMC5/6 loader proteins and associated factors in the silencing of extrachromosomal circular DNA by the SMC5/6 complex. While the findings are largely in line with expectations, they are valuable, representing a meaningful advance beyond the recent study from the same laboratories (PMC9708086), validating the previous model that distinct SMC5/6 subcomplexes, SIMC1-SLF2 and SLF1/2, separately control its transcriptional repression and DNA repair activities on extrachromosomal DNA. Solid evidence is presented for a role for SIMC1/SLF2 in localization of the SMC5/6 complex to plasmid DNA, and the distinct requirements as compared to recruitment of SMC5/6 to chromosomal DNA lesions.

Reviewed by eLife