Cell Biology

  1. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

    1. Jessica Mella
    2. Regan F Volk
    3. Balyn W Zaro
    4. Abigail Buchwalter

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on the delivery of a nuclear envelop protein to lysosomes and the impact of C-terminal tagging on its traffic. The authors provide solid evidence for the potential artifacts introduced by large terminal tags, particularly in the context of membrane protein localization and stability.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  2. Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

    1. Gabriel M Kline
    2. Lisa Boinon
    3. Adrian Guerrero
    4. Sergei Kutseikin
    5. Gabrielle Cruz
    6. Marnie P Williams
    7. Ryan J Paxman
    8. William E Balch
    9. Jeffery W Kelly
    10. Tingwei Mu
    11. R Luke Wiseman

    • Curated by eLife

      eLife Assessment

      This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

    1. Athanasia Sergounioti
    2. Efstathios Alonaris
    3. Dimitrios Rigas

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish

    1. Iga Wasilewska
    2. Łukasz Majewski
    3. Dobrochna Adamek-Urbańska
    4. Sofiia Baranykova
    5. Matylda Macias
    6. Aleksandra Szybińska
    7. Axel Methner

    Reviewed by Review Commons

    16 evaluationsAppears in 1 listLatest version Latest activity

  5. Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

    1. Yaëlle Dubois
    2. Sophie Favier
    3. Nathan Martin-Fornier
    4. Mohyeddine Omrane
    5. David Stroebel
    6. Eric Perez
    7. Sandrine Barbaux
    8. Ahmed Ziyyat
    9. Nicolas Rodriguez
    10. Christine Gourier

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. CellBinDB: a large-scale multimodal annotated dataset for cell segmentation with benchmarking of universal models

    1. Can Shi
    2. Jinghong Fan
    3. Zhonghan Deng
    4. Huanlin Liu
    5. Qiang Kang
    6. Yumei Li
    7. Jing Guo
    8. Jingwen Wang
    9. Jinjiang Gong
    10. Sha Liao
    11. Ao Chen
    12. Ying Zhang
    13. Mei Li

    Reviewed by GigaScience

    2 evaluationsAppears in 1 listLatest version Latest activity

  7. TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

    1. Maria G. Tettamanti
    2. Paulina Nowak
    3. Beata Kusmider
    4. Jennifer M Kefauver
    5. Vincent Mercier
    6. Aurelien Roux
    7. Robbie Loewith

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Mycobacterium tuberculosis -infected macrophages accumulate more nanoparticles

    1. Amine Pochet
    2. Tom Bourguignon
    3. Axelle Grandé
    4. Jesus Alfredo Godinez-Leon
    5. Joan Fine
    6. Priscille Brodin
    7. Arnaud Machelart
    8. Ruxandra Gref

    Reviewed by Rapid Reviews Infectious Diseases

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery

    1. Matthew J. Morris
    2. Yvonne Y. Yeap
    3. Chi Chen
    4. S. Sean Millard
    5. Julia K. Pagan
    6. Dominic C. H. Ng

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells

    1. Maria-Graciela Delgado
    2. Ann-Kathrin Burkhart
    3. Javiera Villar
    4. Roberto Amadio
    5. Vanessa S. Racz
    6. Doriane Sanséau
    7. Nilushi De Silva
    8. Livia Lacerda Mariano
    9. Anna Shmakova
    10. Anna Chipont
    11. Mabel San Roman
    12. Giulia Bracchetti
    13. Vincent Calmettes
    14. Zahraa Alraies
    15. Mathieu Maurin
    16. Aurelien Dauphin
    17. Coralie Guerin
    18. Florent Ginhoux
    19. Nicolas Manel
    20. Daniele Fachinetti
    21. Federica Benvenuti
    22. Sandra Iden
    23. Ana-Maria Lennon-Duménil

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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