1. Hydroxyurea induces ER stress and cytoplasmic protein aggregation

    This article has 8 authors:
    1. Ana Sánchez-Molina
    2. Manuel Bernal
    3. Joel D. Posligua-García
    4. Antonio J. Pérez-Pulido
    5. Laura de Cubas
    6. Elena Hidalgo
    7. Silvia Salas-Pino
    8. Rafael R. Daga

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    This article has 10 authors:
    1. Xiangning Bu
    2. Nathanael Ashby
    3. Teresa Vitali
    4. Sulgi Lee
    5. Ananya Gottumukkala
    6. Kangsun Yun
    7. Sana Tabbara
    8. Patricia Latham
    9. Christine Teal
    10. Inhee Chung
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study provides compelling evidence that TRPV4 plays a crucial role in mechanical sensing during cancer cell transition from non-invasive to invasive states, and offers novel insights into metastasis. By employing multiple experimental approaches, including pharmacological and genetic manipulation, as well as advanced imaging techniques, the authors demonstrate a strong correlation between TRPV4 dynamics, calcium homeostasis, and cell volume plasticity. The findings significantly enhance our understanding of mechanotransduction in cancer and present TRPV4 as a promising therapeutic target for inhibiting metastasis.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  3. Subcellular Region Morphology Reflects Cellular Identity

    This article has 8 authors:
    1. Ángel-Carlos Román
    2. Alba Diaz-Pizarro
    3. Nuria Del Valle-Del Pino
    4. Marcos Olivera-Gómez
    5. Guadalupe Cumplido-Laso
    6. Dixan Agustín Benítez
    7. Jose María Carvajal-González
    8. Sonia Mulero-Navarro

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Stratification of enterochromaffin cells by single-cell expression analysis

    This article has 12 authors:
    1. Yan Song
    2. Linda J Fothergill
    3. Kari S Lee
    4. Brandon Y Liu
    5. Ada Koo
    6. Mark Perelis
    7. Shanti Diwakarla
    8. Brid Callaghan
    9. Jie Huang
    10. Jill Wykosky
    11. John B Furness
    12. Gene W Yeo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents a transcriptomic analysis of enterochromaffin cells in the intestine. The evidence supporting the authors' claims is solid, although the functional analysis is focused on the Piezo2-expressing subset in the colon. The work will be of interest to biologists working on intestinal mucosal biology.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

    This article has 19 authors:
    1. Xiaoning Gao
    2. WuYan Guo
    3. Peiyuan Liu
    4. Mingyue Yuwen
    5. Zixiang Liu
    6. Ruyang Tan
    7. Kairui Liu
    8. Zhiru Yang
    9. Junli Ba
    10. Xue Bai
    11. Shiti Shama
    12. Cong Tang
    13. Kai Miao
    14. Haozhi Pei
    15. Liren Liu
    16. Cheng Zhu
    17. Tao Wang
    18. Bo Zhang
    19. Jun Kang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor, KEAP1, leading to the induction of cytoprotective genes and preventing alcohol-induced gastric damage, offering a potential avenue for treating alcoholism-related gastric disorders. Although improvements were made following the first revision, the evidence supporting capsaicin as an Nrf2 activator remains incomplete, as some methodological aspects still require revision and the interpretation of key data needs further clarification.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain

    This article has 13 authors:
    1. Rubina Dad
    2. Yujuan Wang
    3. Chuyu Fang
    4. Yuncan Chen
    5. Yuan Zhang
    6. Xinwen Pan
    7. Xinyue Zhang
    8. Emily Swanekamp
    9. Krish Patel
    10. Matthias TF Wolf
    11. Zhiguang Yuchi
    12. Xueliang Zhu
    13. Hui-Yuan Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable study that explores the function of CCP5 in mouse ependymal cells. The methods, data, and analyses broadly support the claims. However, the study is incomplete as it stands. Minor weaknesses remain and the authors may wish to address them.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

    This article has 8 authors:
    1. Ellen Späth
    2. Svenja C Schüler
    3. Ivonne Heinze
    4. Therese Dau
    5. Alberto Minetti
    6. Maleen Hofmann
    7. Julia von Maltzahn
    8. Alessandro Ori
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study offers insights into the role of Leiomodin-1 (LMOD1) in muscle stem cell biology, advancing our understanding of myogenic differentiation and indicating LMOD1 as a regulator of muscle regeneration, aging, and exercise adaptation. The integration of in vitro and in vivo approaches, complemented by proteomic and imaging methodologies, is solid. However, certain aspects require further attention to improve the clarity, impact, and overall significance of the work, particularly in substantiating the in vivo relevance. This work will provide a starting point that will be of value to medical biologists and biochemists working on LMOD and its variants in muscle biology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis

    This article has 13 authors:
    1. Sun Woo Sophie Kang
    2. Lauryn A Brown
    3. Colin B Miller
    4. Katherine M Barrows
    5. Jihye L Golino
    6. Constance M Cultraro
    7. Daniel Feliciano
    8. Mercedes B. Cornelius-Muwanuzi
    9. Andy D Tran
    10. Michael Kruhlak
    11. Alexei Lobanov
    12. Maggie Cam
    13. Natalie Porat-Shliom

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    This article has 5 authors:
    1. Lucian DiPeso
    2. Sriram Pendyala
    3. Heather Z Huang
    4. Douglas M Fowler
    5. Emily M Hatch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable paper reports machine learning-based image analysis pipelines for the automated segmentation of micronuclei and the detection and sorting of micronuclei-containing cells. These are powerful new tools for researchers who study micronuclei and their physiologic consequences. The analysis of the new tools and their benchmarking is rigorous and convincing; applications and remaining limitations are well explained in the paper.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    This article has 25 authors:
    1. Slaven Crnkovic
    2. Helene Thekkekara Puthenparampil
    3. Shirin Mulch
    4. Valentina Biasin
    5. Nemanja Radic
    6. Jochen Wilhelm
    7. Marek Bartkuhn
    8. Ehsan Bonyadi Rad
    9. Alicja Wawrzen
    10. Ingrid Matzer
    11. Ankita Mitra
    12. Ryan D Leib
    13. Bence Miklos Nagy
    14. Anita Sahu-Osen
    15. Francesco Valzano
    16. Natalie Bordag
    17. Matthias Evermann
    18. Konrad Hoetzenecker
    19. Andrea Olschewski
    20. Senka Ljubojevic-Holzer
    21. Malgorzata Wygrecka
    22. Kurt Stenmark
    23. Leigh M Marsh
    24. Vinicio de Jesus Perez
    25. Grazyna Kwapiszewska
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental research conducted a molecular comparison between smooth muscle cells and adjacent fibroblast cells within lung blood vessels affected by pulmonary arterial hypertension. The study identified distinct disease-related states in each cell type and provided deeper insights into their interactions and communication. While certain conclusions should be interpreted with caution due to inherent methodological limitations, the study's findings remain convincing and robust. This is supported by the use of advanced and complementary techniques, as well as the rare isolation of diseased lung blood vessel cells from the same donor, enabling direct comparison.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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