Cell Biology

Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion

1. Jessica Wagner
2. Konstantina Feller
3. Nicole Schrenke
4. Nina Schulze
5. Annette Paschen
6. Leif Dehmelt
7. Perihan Nalbant

Reviewed by preLights

Microtubule-dependent cell polarity regulates skin-resident macrophage phagocytosis and directed cell migration

1. Eric Peterman
2. Andrew Murphy
3. Ian A. Swinburne
4. Sean G. Megason
5. Jeffrey P. Rasmussen

Reviewed by PREreview

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

1. Andreas Fellas
2. Alison L. Pidoux
3. Pin Tong
4. Harriet H. Hewes
5. Emma C. Wallace
6. Robin C. Allshire

Reviewed by Review Commons

Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

1. San Pin Steve Wu
2. Elvis Quiroz
3. Tianyuan Wang
4. Skylar G Montague Redecke
5. Xin Xu
6. Lin Lin
7. Matthew L Anderson
8. Francesco J DeMayo

• Curated by eLife

  eLife Assessment

  This valuable study employed a multi-omics approach to elucidate the regulatory mechanism underlying parturition and myometrial quiescence. The data presented to support the main conclusion are solid. This work will be of interest to both basic researchers who work on reproductive biology and clinicians who practice reproductive medicine.

Reviewed by eLife

Cell cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes

1. James P. Kemp
2. Mark S. Geisler
3. Mia Hoover
4. Chun-Yi Cho
5. Patrick H. O’Farrell
6. William F. Marzluff
7. Robert J. Duronio

Reviewed by Review Commons

Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes

1. Sakshi Shambhavi
2. Sudipta Mondal
3. Arnab Chakraborty
4. Nikita Shukla
5. Bapin Kumar Panda
6. Santhosh Kumar
7. Priyadarshan Kinatukara
8. Biswajit Pal
9. Siddhesh S Kamat
10. Rajan Sankaranarayanan

• Curated by eLife

  eLife Assessment

  This is an interesting study that adds useful new data addressing how different DAG pools influence cellular signaling. The study dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from the lipid metabolism DAG pool utilized in membrane production. Overall the analysis is solid and broadly supports the claims.

Reviewed by eLife

Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway

1. Prakhar Agarwal
2. Santanu Kumar Ghosh

Reviewed by Review Commons

A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis

1. Ondrej Maxian
2. Katrina M. Longhini
3. Michael Glotzer

Reviewed by Review Commons

Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster

1. Lydia Grmai
2. Melissa Mychalczuk
3. Aditya Arkalgud
4. Deepika Vasudevan

Reviewed by Review Commons

Disease-associated programming of cell memory in glycogen storage disorder type 1a

1. U Sprecher
2. J D’Souza
3. K Mishra
4. N Muchtar
5. O Shalev
6. A Eliassaf
7. A Morshina
8. A Canella Miliano
9. G Mithieux
10. F Rajas
11. S Avraham
12. F Castellani Moses
13. H Kauffman
14. Y Bergman
15. N Garti
16. S Garti
17. M Linial
18. Y Anikster
19. O Kakhlon
20. M Weil

Reviewed by Review Commons