Cell Biology

Lysosome-Dependent Sphingolipid Regulation as a potential therapeutic Target for Cohen Syndrome

1. Fabrizio Vacca
2. Renuka Prasad
3. Huda Barakullah
4. Romain Da Costa
5. Stefania Vossio
6. Dimitri Moreau
7. Woong Sun
8. Howard Riezman
9. Muhammad Ansar

Reviewed by Review Commons

Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A

1. Annabel Cardno
2. Karen Roberts
3. Catherine Lindon

• Curated by eLife

  eLife Assessment

  This study describes a genetic screen to identify deubiquitinases (DUBs) that counteract the activity of small molecule degraders (PROTACs). The presented data is valuable, identifying OTUD6A and UCHL5 as DUBs that impact the efficacy and potency of PROTAC-mediated degradation in distinct subcellular compartments. While the conclusions are broadly supported and the methods employed are solid, the validation of OTUD6A and UCHL5 mechanisms requires additional study. Overall, these findings merit further evaluation by the targeted protein degradation community when developing and optimizing PROTACs and efforts to achieve compartment-specific degradation.

Reviewed by eLife

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

1. Yu Deng
2. Tatsat Banerjee
3. Satomi Matsuoka
4. Debojyoti Biswas
5. Liz A. Kurtz
6. Jane Borleis
7. Yu Long
8. Parijat Banerjee
9. Huiwang Zhan
10. Dhiman Sankar Pal
11. Nathan H. Roy
12. Masahiro Ueda
13. Pablo A. Iglesias
14. Peter N. Devreotes

Reviewed by preLights

VAMP8 function reveals tight linkage between endocytic recycling and endocytosis

1. Ailing Liu
2. Yueping Li
3. Zheng Huang
4. Wen Chen
5. Peiliu Xu
6. Xiangying Wei
7. Guosheng Hu
8. Shuangquan Liu
9. Xiaoxia Liu
10. Yaohui He
11. Danling Wang
12. Sandra L. Schmid
13. Zhiming Chen

Reviewed by Review Commons

Ubiquitination regulates granulostasis and DRiP accumulation in SGs under heat stress via the E3 ligase MKRN2

1. Emmanuel Amzallag
2. Yehuda M. Danino
3. Valentina Secco
4. Serena Carra
5. Eran Hornstein

Reviewed by Review Commons

A retrograde transit filter mediated by optineurin controls mitostasis in distal axons

1. Natalia A. Marahori
2. Barbara Gailer
3. Martina Schifferer
4. Tatjana Kleele
5. Anna Iatroudi
6. Shabab B. Hannan
7. Petros Avramopoulos
8. Stefan Engelhardt
9. Melike Lakadamyali
10. Monika S. Brill
11. Thomas Misgeld

Reviewed by PREreview

mTORC1 signaling modulate microtubule tyrosination/detyrosination status to regulate lysosome dynamics

1. Jeganath Ammavasai
2. Nitin Mohan

Reviewed by PREreview

Cell type specific allometry controls sex-differences in Drosophila organ size

1. Soumitra Pal
2. Jerome Avellaneda
3. Celena M Cherian
4. Puja Biswas
5. Georg Vogler
6. Elizabeth J Rideout
7. Frank Schnorrer
8. Teresa M Przytycka
9. Brian Oliver

Reviewed by Review Commons