Cancer Biology

Proteomic profiling of advanced hepatocellular carcinoma identifies predictive signatures of response to treatments

1. Adèle Delamarre
2. Marie Decraecker
3. Jean-Frédéric Blanc
4. Sylvaine Di Tommaso
5. Cyril Dourthe
6. Jean-William Dupuy
7. Mélanie Moreau
8. Nathalie Allain
9. Isabelle Mahouche
10. Julie Giraud
11. Giovanni Bénard
12. Claude Lalou
13. Benoît Pinson
14. Paulette Bioulac-Sage
15. Caroline Toulouse
16. Audrey Morisset
17. Jérôme Boursier
18. Brigitte Le Bail
19. Anne-Aurélie Raymond
20. Frédéric Saltel

Reviewed by PREreview

KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

1. Lena Lau
2. Kurt Henderson
3. Ahu Turkoz
4. Sara Linker
5. Dorte Schlessinger
6. Brad Townsley
7. Brian Egan
8. Shoba Ragunathan
9. Robert Rollins
10. Xianju Bi
11. Zhijian J Chen
12. Oleg Brodsky
13. Clifford Restaino
14. Murali Gururajan
15. Kristen Jensen-Pergakes
16. Anders Mälarstig
17. Chames Kermi
18. Paul Moore
19. Marie Classon

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding that KDM5 inhibitors may enable a wide therapeutic window as compared to STING agonists or Type I Interferons. The evidence supporting the claims of the authors is convincing. The work will be of broad interest to scientists working in the field of breast cancer research.

Reviewed by eLife

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

1. Kamila J Bienkowska
2. Stephany Gallardo Y
3. Nur S Zainal
4. Matthew Ellis
5. Maria-Antoinette Lopez
6. Judith Austine
7. Sai Pittla
8. Serena J Chee
9. Aiman Alzetani
10. Emily C Shaw
11. Christian H Ottensmeier
12. Gareth J Thomas
13. Christopher J Hanley

Reviewed by Review Commons

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

1. Roza H. A. Masalmeh
2. John C. Dawson
3. Virginia Alvarez Garcia
4. Morwenna T. Muir
5. Roderick N. Carter
6. Giles Hardingham
7. Cameron Davies
8. Rosina Graham
9. Alex von Kriegsheim
10. Jair Marques Junior
11. Chinmayi Pednekar
12. Steven M. Pollard
13. Neil O. Carragher
14. Valerie G. Brunton
15. Margaret C. Frame

Reviewed by Review Commons

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

1. Wei Qi Guinevere Sew
2. Maria Molano-Fernández
3. Zhiquan Li
4. Artim Lange
5. Nahia Pérez de Ciriza
6. Lene Juel Rasmussen
7. Héctor Herranz

Reviewed by Review Commons

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

1. Christopher B. Nelson
2. Jadon K. Wells
3. Ekaagra Kesarwani
4. Alexander P. Sobinoff
5. Jixuan Gao
6. Karen L. MacKenzie
7. Rebecca C. Poulos
8. Urwah Nawaz
9. Xiang Wang
10. Heide L. Ford
11. Hilda A. Pickett

Reviewed by Review Commons

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

1. Antara Sengupta
2. Soujanya Vinayagamurthy
3. Dristhi Soni
4. Rajlekha Deb
5. Ananda Kishore Mukherjee
6. Subhajit Dutta
7. Jushta Jaiswal
8. Mukta Yadav
9. Shalu Sharma
10. Sulochana Bagri
11. Shuvra Shekhar Roy
12. Priya Poonia
13. Ankita Singh
14. Divya Khanna
15. Amit Kumar Kumar Bhatt
16. Akshay Sharma
17. Suman Saurav
18. Rajender K Motiani
19. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

Reviewed by eLife

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

1. Giulia Silvani
2. Chantal Kopecky
3. Sara Romanazzo
4. Vanina Rodríguez
5. Ayan Das
6. Elvis Pandzic
7. John G. Lock
8. Christine L. Chaffer
9. Kate Poole
10. Kristopher A. Kilian

Reviewed by preLights

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

1. Suzanne Dufresne
2. Ramya S. Kuna
3. Kristiana Wong
4. Anvita Komarla
5. Louis R. Parham
6. Celina Shen
7. Payel Mondal
8. Adelaida Estrada-Cardenas
9. Angelica Rock
10. Joel Encarnación-Rosado
11. Fabiana Izidro Layng
12. Dhanya R. Panickar
13. Nicole A. Bakas
14. Douglas J. Sheffler
15. Allison Limpert
16. Kristina L. Peck
17. Alexandra Fowler
18. Sonja N. Brun
19. Tammy J. Rymoff
20. Andrew M. Lowy
21. Dannielle D. Engle
22. Hervé Tiriac
23. Reuben J. Shaw
24. Nicholas D. P. Cosford
25. Christian M. Metallo
26. Christina G. Towers

Reviewed by preLights