Cancer Biology

Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation

1. Jennifer J Twardowski
2. Thomas I Heist
3. Zamira Guerra Soares
4. Emily S Berry
5. Luis I Ruffolo
6. Christoph Pröschel
7. Stephano S Mello

Reviewed by Review Commons

Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer

1. Xin Zhang
2. Guangyu Zhang
3. Shuli Sang
4. Yang Fei
5. Xiaopeng Cao
6. Wenge Song
7. Feide Liu
8. Jinze Che
9. Haoxia Tao
10. Hongwei Wang
11. Lihua Zhang
12. Yiyan Guan
13. Shipeng Rong
14. Lijuan Pei
15. Sheng Yao
16. Yanchun Wang
17. Min Zhang
18. Chunjie Liu

• Curated by eLife

  eLife Assessment

  This study presents a valuable description of the cellular and transcriptional landscape of the tumor microenvironment in 27 gastric cancer (GC) patients based on their H. pylori status (HpGC, ex-HpGC, non-HpGC). The single-cell RNA sequencing dataset and computational analysis are convincing and provide a starting point that is of value for understanding H pylori-associated GC cell type composition, cell transitions, and mechanisms of response to therapy. The section correlating immunotherapy outcomes with GC cell type compositions from bulk RNAseq would have been strengthened by further comparing H. pylori GC versus non H. pylori GC.

Reviewed by eLife

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

1. Chong Zhang
2. Zuoyan Zhang
3. Yueyi Wu
4. Yuchen Wu
5. Jing Cheng
6. Kaizhi Luo
7. Zhidi Li
8. Manman Zhang
9. Jian Wang
10. Xuesen Zhang
11. Yangling Li

• Curated by eLife

  eLife Assessment

  This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and assays and the evidence shown is solid and has been strengthened by incorporation of suggestions by the two reviewers. The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies.

Reviewed by eLife

Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

1. Yu-Chia Chen
2. Mamoru Takada
3. Aerica Nagornyuk
4. Muhan Yu
5. Hideyuki Yamada
6. Takeshi Nagashima
7. Masayuki Ohtsuka
8. Jennifer G DeLuca
9. Steven M Markus
10. Motoki Takaku
11. Aussie Suzuki

• Curated by eLife

  eLife Assessment

  This study provides valuable findings that MK2 inhibitor CMPD1 can inhibit the growth, migration and invasion of breast cancer cells both in vitro and in vivo. The evidence supporting the claims of the authors is solid, although the detailed molecular mechanism and additional animal experiments would strengthen the paper. This study will be of interest to the breast cancer field.

Reviewed by eLife

Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

1. Xuantong Gong
2. Lishuang Gu
3. Di Yang
4. Yu He
5. Qian Li
6. Hao Qin
7. Yong Wang

• Curated by eLife

  eLife Assessment

  This study presents a useful finding for the ferroptosis-mediated tumor microenvironment (TME) in triple-negative breast cancer (TNBC) using public single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing data. The data were collected and analyzed using solid and validated methodology and can be used as a starting point for functional studies of TME in TNBC. The work will be of interest to medical biologists working in the field of TNBC.

Reviewed by eLife

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

1. David Papadopoli
2. Ranveer Palia
3. Predrag Jovanovic
4. Sébastien Tabariès
5. Emma Ciccolini
6. Valerie Sabourin
7. Sebastian Igelmann
8. Shannon McLaughlan
9. Lesley Zhan
10. HaEun Kim
11. Nabila Chekkal
12. Krzysztof J Szkop
13. Thierry Bertomeu
14. Jibin Zeng
15. Julia Vassalakis
16. Farzaneh Afzali
17. Slim Mzoughi
18. Ernesto Guccione
19. Mike Tyers
20. Daina Avizonis
21. Ola Larsson
22. Lynne-Marie Postovit
23. Sergej Djuranovic
24. Josie Ursini-Siegel
25. Peter M Siegel
26. Michael Pollak
27. Ivan Topisirovic

• Curated by eLife

  eLife Assessment

  The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating that ETFDH suppression results in accumulation of amino acids that impact metabolism via hyperactive mTORC1.

Reviewed by eLife

Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

1. Mei Ling Leong
2. Christiane Ruedl
3. Klaus Karjalainen

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors demonstrate that TCF7L2 plays a role in the pathogenesis of cachexia in a mouse model of GI cancer. The results are solid, although future studies will need further mechanistic analyses. These data will be interesting to cancer biologists, especially those trying to understand late-stage complications such as cachexia and wasting, a major cause of cancer morbidity and mortality.

Reviewed by eLife

Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

1. Shan Li
2. Kai Song
3. Huiyun Sun
4. Yong Tao
5. Arthur Huang
6. Vipul Bhatia
7. Brian Hanratty
8. Radhika A Patel
9. Henry W Long
10. Colm Morrissey
11. Michael C Haffner
12. Peter S Nelson
13. Thomas G Graeber
14. John K Lee

• Curated by eLife

  eLife Assessment

  The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The findings enhance the understanding of the treatment of androgen receptor functions in NEPC.

Reviewed by eLife

Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

1. Rachel Nakagawa
2. Andrew Beardsley
3. Sophia Durney
4. Mary-Kate Hayward
5. Vishvak Subramanyam
6. Nathaniel P Meyer
7. Harrison Wismer
8. Hani Goodarzi
9. Valerie M Weaver
10. Daniel Van de Mark
11. Andrei Goga

• Curated by eLife

  eLife Assessment

  This study identifies a role for YAP in regulating tumor cell growth and drug response with differential effects noted based upon growth conditions in monolayer vs spheroid culture. This work has the potential to define more biologically relevant cell culture model systems for drug resistance and define targetable pathways to overcome drug resistance. The findings described are important to the cancer biology field and the evidence supporting the key findings is convincing.

Reviewed by eLife

Targeting de novo cholesterol synthesis in rhabdomyosarcoma induces cell cycle arrest and triggers apoptosis through ER stress-mediated pathways

1. Nebeyu Yosef Gizaw
2. Kalle Kolari
3. Kari Alitalo
4. Riikka Kivelä

Reviewed by Review Commons