Cancer Biology

Monitoring circulating cell-free HPV DNA in metastatic or recurrent cervical cancer: clinical significance and treatment implications

1. Zhuomin Yin
2. Tao Feng
3. Qing Xu
4. Wumin Dai
5. Maowei Ni
6. Juan Ni
7. Hanmei Lou

• Curated by eLife

  eLife Assessment

  This study presents useful findings on the application of HPV cfDNA as a marker for monitoring treatment response and prognosis in patients with recurrent or metastatic cervical cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to medics and biologists working on cervical cancer.

Reviewed by eLife

Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

1. Deepak Pant
2. Parik Kakani
3. Rushikesh Joshi
4. Abin Sabu
5. Shruti Agrawal
6. Atul Samaiya
7. Sanjeev Shukla

• Curated by eLife

  eLife Assessment

  These useful findings assigned a novel functional implication of histone acylation, crotonylation. Mechanistic insights have been provided in great detail regarding the role of the YEATS2-GCDH axis in modulating epithelial-to-mesenchymal transition (EMT) in head and neck cancer, and overall the strength of evidence is solid.

Reviewed by eLife

Deciphering the CD73⁺ Regulatory γδ T Cell ecosystem associated with poor survival in Ovarian cancer

1. Ghita Chabab
2. Henri-Alexandre Michaud
3. Cécile Dejou
4. Laure-Agnès Chépeaux
5. Yaël Glasson
6. Florence Boissière
7. Marion Lenain
8. Anne-Sophie Dumé
9. Pauline Sarrant
10. Gabriel Chemin
11. Pauline Wajda
12. Bertrand Dubois
13. Anna MacManus
14. Pierre-Emmanuel Colombo
15. Michel Fabbro
16. Nathalie Bonnefoy
17. Maeva Chauvin
18. Virginie Lafont

Reviewed by Review Commons

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

1. Erika Tsingos
2. Advaita M Dick
3. Baubak Bajoghli

• Curated by eLife

  eLife Assessment

  This important study combines agent-based modelling and in vivo experiments in medaka embryos to provide new insights into the role of the thymic niche in T cell development. The modelling yields some interesting and solid findings regarding the importance of thymic epithelial cells. This study would be of interest to oncologists, immunologists, and mathematical modelers.

Reviewed by eLife

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

1. Einav Somech
2. Debdatta Halder
3. Avishay Spitzer
4. Chaya Barbolin
5. Michael Tyler
6. Reut Halperin
7. Moshe Biton
8. Amit Tirosh
9. Itay Tirosh

• Curated by eLife

  eLife Assessment

  This is a valuable study that uses single-cell RNA sequencing to define tumor-intrinsic transcriptional programs that characterize distinct types of small intestine neuroendocrine tumors. The evidence supporting the claims of the authors is solid, but would benefit from a larger sample size. The work will be of interest to cancer biologists studying neuroendocrine tumors, as well as those studying tumor heterogeneity more broadly.

Reviewed by eLife

The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

1. Haibin Liu
2. Lulu Yu
3. Vladimir Majerciak
4. Thomas J Meyer
5. Ming Yi
6. Peter F Johnson
7. Maggie Cam
8. Douglas R Lowy
9. Zhi-Ming Zheng

• Curated by eLife

  eLife Assessment

  This study reports important new insights into the roles of a long noncoding RNA, lnc-FANCI-2, in the progression of cervical cancer induced by a type of human papillomavirus. Through a blend of cell biological, biochemical, and genetic analyses of RNA and protein expression, protein-protein interaction, cell signaling, and cell morphology, the authors provide convincing evidence that lnc-FANCI-2 affects cervical cancer outcome by regulating the RAS signaling pathway. These findings will be of interest to scientists in the fields of cervical cancer, long noncoding RNA, and cell signaling.

Reviewed by eLife

Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies

1. Veera K. Ojala
2. Sini Ahonen
3. Aura Tuohisto-Kokko
4. Olaya Esparta
5. Peppi Suominen
6. Anne Jokilammi
7. Iman Farahani
8. Deepankar Chakroborty
9. Nikol Dibus
10. Steffen Boettcher
11. Tomi T. Airenne
12. Mark S. Johnson
13. Lisa D. Eli
14. Klaus Elenius
15. Kari J. Kurppa

Reviewed by Review Commons

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

1. Sarah M Chang
2. Muhammad Bin Munim
3. Sonia E Trojan
4. Anna Shevzov-Zebrun
5. Keene L Abbott
6. Matthew G Vander Heiden

• Curated by eLife

  eLife Assessment

  This study presents valuable findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide solid evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of interest to researchers working in cancer and cell metabolism.

Reviewed by eLife

Tumoral CD24 tunes platelets binding and pro-metastatic functions

1. Vincent Mittelheisser
2. Cristina Liboni
3. Clarisse Mouriaux
4. Silvia Maria Grazia Trivigno
5. Louis Bochler
6. Maria Garcia-Leon
7. Annabel Larnicol
8. Laetitia Paulen
9. Tristan Stemmelen
10. Pierre Henri Mangin
11. Olivier Lefebvre
12. Jacky G. GOETZ

Reviewed by preLights

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

1. Jiongke Wang
2. Yujie Shi
3. Ying Wang
4. Yingqiang Shen
5. Huan Liu
6. Silu Sun
7. Yimei Wang
8. Xikun Zhou
9. Yu Zhou
10. Xin Zeng
11. Jing Li
12. Qianming Chen

• Curated by eLife

  eLife Assessment

  This manuscript determines how PA28g, a proteasome regulator that is overexpressed in tumors, and C1QBP, a mitochondrial protein for maintaining oxidative phosphorylation that plays a role in tumor progression, interact in tumor cells to promote their growth, migration and invasion. Additional experiments and analyses that supported the theoretical models for the interaction have been performed in response to the reviews. The overall findings and conceptual framework are important and the evidence is solid. A logical extrapolation of this work is to test the C1QBP mutants using functional assays to determine whether the mutations can decrease the protein stability mediated by the interaction with PA28g.

Reviewed by eLife