Cancer Biology

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers

1. Adrien Tourneur
2. Joel Rodrigues Vitória
3. Manuel Saiselet
4. Ligia Craciun
5. Denis Larsimont
6. Anne Lefort
7. Frederick Libert
8. Carine Maenhaut
9. Sabine Costagliola
10. Maxime Tarabichi
11. Mirian Romitti
12. Vincent Detours

Reviewed by Review Commons

The G protein-coupled receptor TBXA2R activates ERMs to control cell motility and invasion of triple-negative breast cancer cells.

1. Kevin Leguay
2. Omaima Naffati
3. Yu Yan He
4. Mireille Rogue
5. Chloe Tesniere
6. Melania Gombos
7. Hellen Kuasne
8. Louis Gaboury
9. Christian Le Gouill
10. Sylvain Meloche
11. Michel Bouvier
12. Sebastien Carreno

Reviewed by Review Commons

Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

1. Yao Wang
2. Hara Apostolopoulou
3. Im Hong Sun
4. Arjan Bains
5. David Gibbs
6. Sui Huang
7. Tamara Alliston
8. Ajay Maker
9. Thea Tlsty
10. Vasilis Ntranos
11. James M Gardner
12. Anil Bhushan

• Curated by eLife

  eLife Assessment

  This study presents an important finding by identifying OPG as a novel stromal checkpoint influencing T-cell anti-tumor responses, thereby shedding new light on the complex interplay between the tumor microenvironment and immune regulation. The data are robust and the experimental approaches are sound, providing solid support for the study's conclusions; however, there are a number of additional questions raised by the data. Of particular note are the questions raised on the mechanistic effects of TRAIL versus RANKL. In addition, it would broaden the interest in this study to include more translational human data to complement the work presented.

Reviewed by eLife

In depth profiling of the cancer proteome from the flowthrough of standard RNA- preparation kits for precision oncology

1. Filip Mundt Madsen
2. Annelaura Bach Nielsen
3. Juanjuan Wang
4. Josephine Kerzel Duel
5. Christina Westmose Yde
6. Martina Amnitzbøll Eriksen
7. Ulrik Lassen
8. Finn Cilius Nielsen
9. Kristoffer Rohrberg
10. Matthias Mann

Reviewed by preLights