Cancer Biology

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

1. Kamila J Bienkowska
2. Stephany Gallardo Y
3. Nur S Zainal
4. Matthew Ellis
5. Maria-Antoinette Lopez
6. Judith Austine
7. Sai Pittla
8. Serena J Chee
9. Aiman Alzetani
10. Emily C Shaw
11. Christian H Ottensmeier
12. Gareth J Thomas
13. Christopher J Hanley

Reviewed by Review Commons

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

1. Roza H. A. Masalmeh
2. John C. Dawson
3. Virginia Alvarez Garcia
4. Morwenna T. Muir
5. Roderick N. Carter
6. Giles Hardingham
7. Cameron Davies
8. Rosina Graham
9. Alex von Kriegsheim
10. Jair Marques Junior
11. Chinmayi Pednekar
12. Steven M. Pollard
13. Neil O. Carragher
14. Valerie G. Brunton
15. Margaret C. Frame

Reviewed by Review Commons

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

1. Wei Qi Guinevere Sew
2. Maria Molano-Fernández
3. Zhiquan Li
4. Artim Lange
5. Nahia Pérez de Ciriza
6. Lene Juel Rasmussen
7. Héctor Herranz

Reviewed by Review Commons

Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1 regulator of cap-dependent translation

1. Ismail M Meraz
2. Shuhong Wu
3. Yi Xu
4. Lihui Gao
5. Meng Feng
6. Chenghui Ren
7. Renduo Song
8. Ran Zhang
9. Qi Wang
10. Yuanxin Xi
11. Sung Yun Jung
12. Jing Wang
13. Bingliang Fang
14. Mourad Majidi
15. Jack A Roth

• Curated by eLife

  eLife Assessment

  The authors investigate mechanisms of acquired resistance (AR) to KRAS-G12C inhibitors (sotorasib) in non-small cell lung cancer, proposing that resistance arises from signaling rewiring rather than additional mutations. While the study addresses a valuable clinical question, it is limited by several weaknesses in experimental rigor, data interpretation, and presentation, meaning the strength of evidence is incomplete

Reviewed by eLife

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

1. Christopher B. Nelson
2. Jadon K. Wells
3. Ekaagra Kesarwani
4. Alexander P. Sobinoff
5. Jixuan Gao
6. Karen L. MacKenzie
7. Rebecca C. Poulos
8. Urwah Nawaz
9. Xiang Wang
10. Heide L. Ford
11. Hilda A. Pickett

Reviewed by Review Commons

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

1. Antara Sengupta
2. Soujanya Vinayagamurthy
3. Dristhi Soni
4. Rajlekha Deb
5. Ananda Kishore Mukherjee
6. Subhajit Dutta
7. Jushta Jaiswal
8. Mukta Yadav
9. Shalu Sharma
10. Sulochana Bagri
11. Shuvra Shekhar Roy
12. Priya Poonia
13. Ankita Singh
14. Divya Khanna
15. Amit Kumar Kumar Bhatt
16. Akshay Sharma
17. Suman Saurav
18. Rajender K Motiani
19. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

Reviewed by eLife

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

1. Giulia Silvani
2. Chantal Kopecky
3. Sara Romanazzo
4. Vanina Rodríguez
5. Ayan Das
6. Elvis Pandzic
7. John G. Lock
8. Christine L. Chaffer
9. Kate Poole
10. Kristopher A. Kilian

Reviewed by preLights

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

1. Suzanne Dufresne
2. Ramya S. Kuna
3. Kristiana Wong
4. Anvita Komarla
5. Louis R. Parham
6. Celina Shen
7. Payel Mondal
8. Adelaida Estrada-Cardenas
9. Angelica Rock
10. Joel Encarnación-Rosado
11. Fabiana Izidro Layng
12. Dhanya R. Panickar
13. Nicole A. Bakas
14. Douglas J. Sheffler
15. Allison Limpert
16. Kristina L. Peck
17. Alexandra Fowler
18. Sonja N. Brun
19. Tammy J. Rymoff
20. Andrew M. Lowy
21. Dannielle D. Engle
22. Hervé Tiriac
23. Reuben J. Shaw
24. Nicholas D. P. Cosford
25. Christian M. Metallo
26. Christina G. Towers

Reviewed by preLights

Monitoring circulating cell-free HPV DNA in metastatic or recurrent cervical cancer: clinical significance and treatment implications

1. Zhuomin Yin
2. Tao Feng
3. Qing Xu
4. Wumin Dai
5. Maowei Ni
6. Juan Ni
7. Hanmei Lou

• Curated by eLife

  eLife Assessment

  This study presents useful findings on the application of HPV cfDNA as a marker for monitoring treatment response and prognosis in patients with recurrent or metastatic cervical cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to medics and biologists working on cervical cancer.

Reviewed by eLife