Cancer Biology

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

1. Christopher B. Nelson
2. Jadon K. Wells
3. Ekaagra Kesarwani
4. Alexander P. Sobinoff
5. Jixuan Gao
6. Karen L. MacKenzie
7. Rebecca C. Poulos
8. Urwah Nawaz
9. Xiang Wang
10. Heide L. Ford
11. Hilda A. Pickett

Reviewed by Review Commons

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

1. Antara Sengupta
2. Soujanya Vinayagamurthy
3. Dristhi Soni
4. Rajlekha Deb
5. Ananda Kishore Mukherjee
6. Subhajit Dutta
7. Jushta Jaiswal
8. Mukta Yadav
9. Shalu Sharma
10. Sulochana Bagri
11. Shuvra Shekhar Roy
12. Priya Poonia
13. Ankita Singh
14. Divya Khanna
15. Amit Kumar Kumar Bhatt
16. Akshay Sharma
17. Suman Saurav
18. Rajender K Motiani
19. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

Reviewed by eLife

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

1. Giulia Silvani
2. Chantal Kopecky
3. Sara Romanazzo
4. Vanina Rodríguez
5. Ayan Das
6. Elvis Pandzic
7. John G. Lock
8. Christine L. Chaffer
9. Kate Poole
10. Kristopher A. Kilian

Reviewed by preLights

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer

1. Suzanne Dufresne
2. Ramya S. Kuna
3. Kristiana Wong
4. Anvita Komarla
5. Louis R. Parham
6. Celina Shen
7. Payel Mondal
8. Adelaida Estrada-Cardenas
9. Angelica Rock
10. Joel Encarnación-Rosado
11. Fabiana Izidro Layng
12. Dhanya R. Panickar
13. Nicole A. Bakas
14. Douglas J. Sheffler
15. Allison Limpert
16. Kristina L. Peck
17. Alexandra Fowler
18. Sonja N. Brun
19. Tammy J. Rymoff
20. Andrew M. Lowy
21. Dannielle D. Engle
22. Hervé Tiriac
23. Reuben J. Shaw
24. Nicholas D. P. Cosford
25. Christian M. Metallo
26. Christina G. Towers

Reviewed by preLights

Monitoring circulating cell-free HPV DNA in metastatic or recurrent cervical cancer: clinical significance and treatment implications

1. Zhuomin Yin
2. Tao Feng
3. Qing Xu
4. Wumin Dai
5. Maowei Ni
6. Juan Ni
7. Hanmei Lou

• Curated by eLife

  eLife Assessment

  This study presents useful findings on the application of HPV cfDNA as a marker for monitoring treatment response and prognosis in patients with recurrent or metastatic cervical cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to medics and biologists working on cervical cancer.

Reviewed by eLife

Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer

1. Deepak Pant
2. Parik Kakani
3. Rushikesh Joshi
4. Abin Sabu
5. Shruti Agrawal
6. Atul Samaiya
7. Sanjeev Shukla

• Curated by eLife

  eLife Assessment

  These useful findings assigned a novel functional implication of histone acylation, crotonylation. Mechanistic insights have been provided in great detail regarding the role of the YEATS2-GCDH axis in modulating epithelial-to-mesenchymal transition (EMT) in head and neck cancer, and overall the strength of evidence is solid.

Reviewed by eLife

Deciphering the CD73⁺ Regulatory γδ T Cell ecosystem associated with poor survival in Ovarian cancer

1. Ghita Chabab
2. Henri-Alexandre Michaud
3. Cécile Dejou
4. Laure-Agnès Chépeaux
5. Yaël Glasson
6. Florence Boissière
7. Marion Lenain
8. Anne-Sophie Dumé
9. Pauline Sarrant
10. Gabriel Chemin
11. Pauline Wajda
12. Bertrand Dubois
13. Anna MacManus
14. Pierre-Emmanuel Colombo
15. Michel Fabbro
16. Nathalie Bonnefoy
17. Maeva Chauvin
18. Virginie Lafont

Reviewed by Review Commons

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

1. Erika Tsingos
2. Advaita M Dick
3. Baubak Bajoghli

• Curated by eLife

  eLife Assessment

  This important study combines agent-based modelling and in vivo experiments in medaka embryos to provide new insights into the role of the thymic niche in T cell development. The modelling yields some interesting and solid findings regarding the importance of thymic epithelial cells. This study would be of interest to oncologists, immunologists, and mathematical modelers.

Reviewed by eLife

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

1. Einav Somech
2. Debdatta Halder
3. Avishay Spitzer
4. Chaya Barbolin
5. Michael Tyler
6. Reut Halperin
7. Moshe Biton
8. Amit Tirosh
9. Itay Tirosh

• Curated by eLife

  eLife Assessment

  This is a valuable study that uses single-cell RNA sequencing to define tumor-intrinsic transcriptional programs that characterize distinct types of small intestine neuroendocrine tumors. The evidence supporting the claims of the authors is solid, but would benefit from a larger sample size. The work will be of interest to cancer biologists studying neuroendocrine tumors, as well as those studying tumor heterogeneity more broadly.

Reviewed by eLife