Cancer Biology

  1. Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1, a regulator of cap-dependent translation

    1. Ismail M Meraz
    2. Shuhong Wu
    3. Yi Xu
    4. Lihui Gao
    5. Meng Feng
    6. Chenghui Ren
    7. Renduo Song
    8. Ran Zhang
    9. Qi Wang
    10. Yuanxin Xi
    11. Sung Yun Jung
    12. Jing Wang
    13. Bingliang Fang
    14. Mourad Majidi
    15. Jack A Roth

    • Curated by eLife

      eLife Assessment

      The authors investigate mechanisms of acquired resistance (AR) to KRAS-G12C inhibitors (sotorasib) in non-small cell lung cancer, proposing that resistance arises from signaling rewiring rather than additional mutations. While the study addresses a valuable clinical question, it is limited by several weaknesses in experimental rigor, data interpretation, and presentation, meaning the strength of evidence is incomplete.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  2. Design of combination therapeutics from protein response to drugs in ovarian cancer cells

    1. Alexandra Franz
    2. Ciyue Shen
    3. Fabian Coscia
    4. Kenneth Munroe
    5. Lea Charaoui
    6. Anil Korkut
    7. Matthias Mann
    8. Augustin Luna
    9. Chris Sander

    • Curated by eLife

      eLife Assessment

      In this important study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, data-independent acquisition proteomics, and bioinformatic analysis. The authors convincingly identify several combinations of pharmaceuticals that were able to overcome or prevent therapeutic resistance in culture models of ovarian cancer, a disease with an unmet diagnostic and therapeutic need. This work will be of interest to researchers focused on ovarian cancer.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  3. Caveolin-1 regulates context-dependent signaling and survival in Ewing sarcoma

    1. Dagan Segal
    2. Xiaoyu Wang
    3. Hanieh Mazloom-Farisbaf
    4. Felix Y. Zhou
    5. Divya Rajendran
    6. Erin Butler
    7. Bingying Chen
    8. Bo-Jui Chang
    9. Khushi Ahuja
    10. Averi Perny
    11. Kushal Bhatt
    12. Dana Kim Reed
    13. Diego H. Castrillon
    14. Jeon Lee
    15. Elise Jeffery
    16. Lei Wang
    17. Khai Nguyen
    18. Noelle S. Williams
    19. Stephen X. Skapek
    20. Satwik Rajaram
    21. Reto Fiolka
    22. Khuloud Jaqaman
    23. Gary Hon
    24. James F. Amatruda
    25. Gaudenz Danuser

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Ancient and Animal-Specific Regulatory Modes of EWS::FLI1 Revealed by a Minimal Yeast Model

    1. Diego Velázquez
    2. Cristina Molnar
    3. Jose Reina
    4. Jaume Mora
    5. Cayetano Gonzalez

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Cellular Composition Accounts for Much of the Bulk Glutamine–IFN-γ Transcriptional Axis in Melanoma: A Cross-Cohort and Single-Cell Analysis

    1. Islam Asal

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage–T cell axis in glioma

    1. Zehui Du
    2. Menghan Li
    3. Brandon H Bergsneider
    4. Andy P Tsai
    5. Kwang Bog Cho
    6. Lily H Kim
    7. John Choi
    8. Gordon Li
    9. Tony Wyss-Coray
    10. Michael Lim
    11. Xinnan Wang

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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