1. p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    This article has 15 authors:
    1. Ravi Kumar
    2. Simon Couly
    3. Bruna R Muys
    4. Xiao Ling Li
    5. Ioannis Grammatikakis
    6. Ragini Singh
    7. Mary Guest
    8. Xinyu Wen
    9. Wei Tang
    10. Stefan Ambs
    11. Lisa M Jenkins
    12. Erica C Pehrsson
    13. Raj Chari
    14. Tsung-Ping Su
    15. Ashish Lal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this study, the authors investigate the role of ZMAT3, a p53 target gene, in tumor suppression and RNA splicing regulation. Using quantitative proteomics, the authors uncover that ZMAT3 knockout leads to upregulation of HKDC1, a gene linked to mitochondrial respiration, and that ZMAT3 suppresses HKDC1 expression by inhibiting c-JUN-mediated transcription. This set of convincing evidence reveals a fundamental mechanism by which ZMAT3 contributes to p53-driven tumor suppression by regulating mitochondrial respiration.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Design of combination therapeutics from protein response to drugs in ovarian cancer cells

    This article has 9 authors:
    1. Alexandra Franz
    2. Ciyue Shen
    3. Fabian Coscia
    4. Kenneth Munroe
    5. Lea Charaoui
    6. Anil Korkut
    7. Matthias Mann
    8. Augustin Luna
    9. Chris Sander
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, data-independent acquisition proteomics, and bioinformatic analysis. The authors convincingly identify several combinations of pharmaceuticals that were able to overcome or prevent therapeutic resistance in culture models of ovarian cancer, a disease with an unmet diagnostic and therapeutic need. However, the extent to which these findings may extend to more complex models of ovarian cancer remains unclear.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Tumoral CD24 tunes platelets binding and pro-metastatic functions

    This article has 12 authors:
    1. Vincent Mittelheisser
    2. Cristina Liboni
    3. Clarisse Mouriaux
    4. Silvia Maria Grazia Trivigno
    5. Louis Bochler
    6. Maria Garcia-Leon
    7. Annabel Larnicol
    8. Laetitia Paulen
    9. Tristan Stemmelen
    10. Pierre Henri Mangin
    11. Olivier Lefebvre
    12. Jacky G. GOETZ

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    This article has 12 authors:
    1. Jiongke Wang
    2. Yujie Shi
    3. Ying Wang
    4. Yingqiang Shen
    5. Huan Liu
    6. Silu Sun
    7. Yimei Wang
    8. Xikun Zhou
    9. Yu Zhou
    10. Xin Zeng
    11. Jing Li
    12. Qianming Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript determines how PA28g, a proteasome regulator that is overexpressed in tumors, and C1QBP, a mitochondrial protein for maintaining oxidative phosphorylation that plays a role in tumor progression, interact in tumor cells to promote their growth, migration and invasion. Additional experiments and analyses that supported the theoretical models for the interaction have been performed in response to the reviews. The overall findings and conceptual framework are important and the evidence is solid. A logical extrapolation of this work is to test the C1QBP mutants using functional assays to determine whether the mutations can decrease the protein stability mediated by the interaction with PA28g.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  5. BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

    This article has 13 authors:
    1. Emilio Rios-Jimenez
    2. Anoek Zomer
    3. Raphael Collot
    4. Mario Barrera Román
    5. Sandra F Archidona
    6. Hendrikus CR Ariese
    7. Ravian L van Ineveld
    8. Michiel Kleinnijenhuis
    9. Nils Bessler
    10. Hannah Johnson
    11. Caleb A Dawson
    12. Anne Rios
    13. Maria Alieva
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a useful tool for code-less analysis of patterns in cell migratory behaviours in vivo using intravital microscopy data and allows correlation with spatial features of the tumour microenvironment. There is a need for these tools to make quantitative analysis, comparison and interpretation of complex cell tracking data more accessible and evidence is provided of its applicability to tracks generated by both proprietary and open tracking software. However, it is incomplete due to limitations imposed by the assumptions that apply to the statistical tests employed.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  6. PRMT1-mediated metabolic reprogramming promotes leukemogenesis

    This article has 24 authors:
    1. Hairui Su
    2. Yong Sun
    3. Han Guo
    4. Chiao-Wang Sun
    5. Qiuying Chen
    6. Szumam Liu
    7. Anlun Li
    8. Min Gao
    9. Rui Zhao
    10. Glen Raffel
    11. Jian Jin
    12. Cheng-Kui Qu
    13. Michael Yu
    14. Christopher A Klug
    15. George Y Zheng
    16. Scott Ballinger
    17. Matthew Kutny
    18. Long X Zheng
    19. Zechen Chong
    20. Chamara Senevirathne
    21. Steven Gross
    22. Yabing Chen
    23. Minkui Luo
    24. Xinyang Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reveals that PRMT1 overexpression drives tumorigenesis of acute megakaryocytic leukemia (AMKL) and that targeting PRMT1 is a viable approach for treating AMKL. After revision, both reviewers found that these findings are important and that the data supporting these findings are convincing. Furthermore, these findings likely have significant implications for the treatment of AMKL with PRMT1 overexpression in the future.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  7. Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

    This article has 11 authors:
    1. Laleh S Arabanian
    2. Jenni Adamsson
    3. Anke Unger
    4. Raffaella Di Lucrezia
    5. Tim Bergbrede
    6. Arghavan Ashouri
    7. Erik Larsson
    8. Peter Nussbaumer
    9. Bert M Klebl
    10. Lars Palmqvist
    11. Claes M Gustafsson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This solid study assesses a mitochondrial polymerase inhibitor in combination with the BCL-2 inhibitor venetoclax, with the aim to increase the elimination of acute myeloid leukemia. It provides valuable findings of combinatorial efficacy using preclinical models in vitro and in vivo, confirming the overall importance of targeting oxidative phosphorylation to overcome venetoclax resistance in acute myeloid leukemia, and could be strengthened through mechanistic studies demonstrating on target effects and pharmacodynamic efficacy in vivo. The study is of interest to hematologists because it addresses a key biomedical issue in acute myeloid leukemia (venetoclax resistance) and provides data regarding the safety and activity of a novel inhibitor of the mitochondrial polymerase in combination with venetoclax.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

    This article has 20 authors:
    1. Shengsheng Zhao
    2. Ji Lin
    3. Bingzi Zhu
    4. Yin Jin
    5. Qiantong Dong
    6. Xiaojiao Ruan
    7. Dan Jin
    8. Yongdong Yi
    9. Binglong Bai
    10. Hongzheng Li
    11. Danna Liang
    12. Jianhua Lu
    13. Letian Meng
    14. Xiang Wang
    15. Yuekai Cui
    16. Yuyang Gu
    17. Xian Shen
    18. Xufeng Lu
    19. Shangrui Rao
    20. Weijian Sun
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. After major revisions, the evidence supporting the conclusions is solid. However, some new experiments are needed to draw more robust conclusions regarding the ferroptosis-associated studies.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

    This article has 6 authors:
    1. Aamena Y Patel
    2. Peyman Zarrineh
    3. Jigar H Sheth
    4. Sumitra Mohan
    5. Mudassar Iqbal
    6. Sankari Nagarajan

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Drug-Induced p53 Activation Limits Pancreatic Cancer Initiation

    This article has 7 authors:
    1. Jennifer J Twardowski
    2. Thomas I Heist
    3. Zamira Guerra Soares
    4. Emily S Berry
    5. Luis I Ruffolo
    6. Christoph Pröschel
    7. Stephano S Mello

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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