Cancer Biology

Tks5 interactome reveals ER-associated machinery translation in invadosomes

1. Léa Normand
2. Benjamin Bonnard
3. Margaux Sala
4. Sylvaine Di-Tommaso
5. Cyril Dourthe
6. Anne-Aurélie Raymond
7. Jean-William Dupuy
8. Luc Mercier
9. Jacky G. Goetz
10. Violaine Moreau
11. Elodie Henriet
12. Frédéric Saltel

Reviewed by Review Commons

Interplay of YEATS2 and GCDH mediates histone crotonylation and drives EMT in head and neck cancer

1. Deepak Pant
2. Parik Kakani
3. Rushikesh Joshi
4. Shruti Agrawal
5. Atul Samaiya
6. Sanjeev Shukla

• Curated by eLife

  eLife Assessment

  These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2-GCDH axis in modulating EMT in HNC, the strength of evidence for the manuscript is incomplete. The patient cohort is very small, with just 10 patients; to establish a significant result the cohort size should be increased. Furthermore, the functional implication of p300 is also to be looked into.

Reviewed by eLife

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

1. Fei Yue
2. Amy T Ku
3. Payton D Stevens
4. Megan N Michalski
5. Weiyu Jiang
6. Jianghua Tu
7. Zhongcheng Shi
8. Yongchao Dou
9. Yi Wang
10. Xin-Hua Feng
11. Galen Hostetter
12. Xiangwei Wu
13. Shixia Huang
14. Noah F Shroyer
15. Bing Zhang
16. Bart O Williams
17. Qingyun Liu
18. Xia Lin
19. Yi Li

• Curated by eLife

  eLife Assessment

  This manuscript presents solid evidence suggesting that the loss of ZNRF3 and RNF43, two E3 ubiquitin ligases, leads to dysregulation of EGFR signaling in cancer. The authors propose that EGFR is a direct substrate of ZNRF3/RNF43. While the authors provide immunoprecipitation data showing increased detection of ubiquitinated species, this evidence does not definitively establish that EGFR itself is ubiquitinated by RNF43/ZNRF3. The absence of direct evidence for EGFR ubiquitination is a major limitation, although the findings are useful as they may provide novel insights into the mechanisms underlying EGFR-driven cancers and open new therapeutic avenues.

Reviewed by eLife

PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

1. Hairui Su
2. Yong Sun
3. Han Guo
4. Chiao-Wang Sun
5. Qiuying Chen
6. Szumam Liu
7. Anlun Li
8. Min Gao
9. Rui Zhao
10. Glen Raffel
11. Jian Jin
12. Cheng-Qui Qu
13. Michael Yu
14. Christopher A. Klug
15. George Y. Zheng
16. Scott Ballinger
17. Matthew Kutny
18. X. Long Zheng
19. Zechen Chong
20. Chamara Senevirathne
21. Steve Gross
22. Yabing Chen
23. Minkui Luo
24. Xinyang Zhao

• Curated by eLife

  eLife Assessment

  This study reveals that PRMT1 overexpression drives tumorigenesis of acute megakaryocytic leukemia (AMKL) and that targeting PRMT1 is a viable approach for treating AMKL. While the evidence, based largely on one cell line, is convincing, further validations in additional experiment settings will solidify the conclusion. These findings have important implications for the treatment of AMKL with PRMT1 over expression in the future.

Reviewed by eLife

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women

1. Neil Carleton
2. Sanghoon Lee
3. Ruxuan Li
4. Jian Zou
5. Daniel D Brown
6. Jagmohan Hooda
7. Alexander Chang
8. Rahul Kumar
9. Linda R Klei
10. Lora H Rigatti
11. Joseph Newsome
12. Dixcy Jaba Sheeba John Mary
13. Jennifer M Atkinson
14. Raymond E West
15. Thomas D Nolin
16. Patrick J Oberly
17. Ziyu Huang
18. Donald Poirier
19. Emilia J Diego
20. Peter C Lucas
21. George Tseng
22. Michael T Lotze
23. Priscilla F McAuliffe
24. Ioannis K Zervantonakis
25. Steffi Oesterreich
26. Adrian V Lee

Reviewed by PREreview

A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

1. Saima Usman
2. W Andrew Yeudall
3. Muy-Teck Teh
4. Fatemah Ghloum
5. Hemanth Tummala
6. Ahmad Waseem

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding that C238 in vimentin regulates long non-coding RNA XIST to suppress EMT and thereby Xist may be a therapeutic target in breast cancer. The evidence supporting the claims of the authors is solid, although the improvement of data visibility and presentation would have strengthened the study. The work will be of interest to scientists working in the field of BCs.

Reviewed by eLife

Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors

1. Sara M Frangos
2. Henver S Brunetta
3. Dongdong Wang
4. Maria Joy Therese Jabile
5. David WL Ma
6. William J Muller
7. Cezar M Khursigara
8. Kelsey H Fisher-Wellman
9. Gregory R Steinberg
10. Graham P Holloway

• Curated by eLife

  eLife Assessment

  This useful study uses the MMTV-Neu-YD5 mouse model for HER2-dependent breast cancer to generate transcriptomic and proteomic datasets from extracted primary tumour samples. The data sets generated appear to be solid and will be of interest to the community. However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate aspects such as cellular heterogeneity, and signalling.

Reviewed by eLife

Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

1. Yijia Hua
2. Ningjun Duan
3. Chunxiao Sun
4. Fan Yang
5. Min Tian
6. Yanting Sun
7. Shuhan Zhao
8. Jue Gong
9. Qian Liu
10. Xiang Huang
11. Yan Liang
12. Ziyi Fu
13. Wei Li
14. Yongmei Yin

• Curated by eLife

  eLife Assessment

  This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the authors may want to validate their results in additional cell lines to strengthen their conclusions. Moreover, the authors should clarify the source of patient samples and why the manuscript focused on epigenetic regulations instead of major transcription factors. The work will be of interest to scientists working in the field of breast cancer.

Reviewed by eLife

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

1. Connor M Hill
2. Alexandra Indeglia
3. Francis Picone
4. Maureen E Murphy
5. Cara Cipriano
6. Robert G Maki
7. Alessandro Gardini

• Curated by eLife

  eLife Assessment

  This study provides compelling data regarding the molecular characterization of a rare tumor type with few treatment options. This fundamental work significantly advances our mechanistic understanding of solitary fibrous tumours, a critical first step towards targeted precision medicine approaches. The results of this study will be of broad interest to cancer biologists and experimental oncologists.

Reviewed by eLife

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

1. Rui Vasco Simoes
2. Rafael Neto Henriques
3. Jonas L Olesen
4. Beatriz M Cardoso
5. Francisca F Fernandes
6. Mariana AV Monteiro
7. Sune N Jespersen
8. Tânia Carvalho
9. Noam Shemesh

• Curated by eLife

  eLife Assessment

  This study provides a valuable approach to image and analyze in vivo metabolic flux through glucose turnover kinetics in glioblastoma tumor microenvironments. The evidence for the method's validity is convincing, which establishes the dynamic Deuterium Metabolic Imaging technique as an effective tool enabling non-invasive exploration of various tumors.

Reviewed by eLife