Cancer Biology

RAS and PP2A activities converge on epigenetic gene regulation

1. Anna Aakula
2. Mukund Sharma
3. Francesco Tabaro
4. Reetta Nätkin
5. Jesse Kamila
6. Henrik Honkanen
7. Matthieu Schapira
8. Cheryl Arrowsmith
9. Matti Nykter
10. Jukka Westermarck

Reviewed by Review Commons

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

1. Kexin Li
2. Qingji Huo
3. Nathan H Dimmitt
4. Guofan Qu
5. Junjie Bao
6. Pankita H Pandya
7. M Reza Saadatzadeh
8. Khadijeh Bijangi-Vishehsaraei
9. Melissa A Kacena
10. Karen E Pollok
11. Chien-Chi Lin
12. Bai-Yan Li
13. Hiroki Yokota

• Curated by eLife

  eLife assessment

  There are no known effective treatments available to date for the treatment of osteosarcomas, the earliest identified bone cancer that can spread to other tissues. In this study, the authors have used novel approaches to identify calreticulin and procollagen C-endopeptidase enhancer (PCOLCE) as osteosarcoma tumor suppressor proteins that inhibit osteosarcoma growth both in animal and in vitro cell culture models. These important findings may provide a basis for the future development of more efficient targeted therapies for the treatment of osteosarcomas.

Reviewed by eLife

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

1. Takuya Kato
2. Robert P Jenkins
3. Stefanie Derzsi
4. Melda Tozluoglu
5. Antonio Rullan
6. Steven Hooper
7. Raphaël AG Chaleil
8. Holly Joyce
9. Xiao Fu
10. Selvam Thavaraj
11. Paul A Bates
12. Erik Sahai

• Curated by eLife

  eLife assessment

  This study addresses several gaps that are evident with regards to cancer cell invasion in tissue. The approaches taken by this group encompassing mathematical modeling and experimental procedures are for the most part rigorous. The study is deemed as of high potential impact.

Reviewed by eLife

Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening

1. Ateequllah Hayat
2. Edward P. Carter
3. Hamish W. King
4. Aysegul Ors
5. Aaron Doe
6. Saul A. Teijeiro
7. Sarah Charrot
8. Susana Godinho
9. Pedro Cutillas
10. Hisham Mohammed
11. Richard P. Grose
12. Gabriella Ficz

Reviewed by Review Commons

EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry

1. Haitao Luan
2. Timothy A Bielecki
3. Bhopal C Mohapatra
4. Namista Islam
5. Insha Mushtaq
6. Aaqib M Bhat
7. Sameer Mirza
8. Sukanya Chakraborty
9. Mohsin Raza
10. Matthew D Storck
11. Michael S Toss
12. Jane L Meza
13. Wallace B Thoreson
14. Donald W Coulter
15. Emad A Rakha
16. Vimla Band
17. Hamid Band

• Curated by eLife

  eLife assessment

  This study, supported by reasonably solid evidence, will be of interest to breast cancer researchers. The finding that EHD2 promotes tumor growth and impacts store-operated calcium entry (SOCE) adds to our understanding of breast cancer cell physiology. If supported by further research, the study provides a rationale for using SOCE inhibitors in a subset of breast cancers, with high expression of EHD2 serving as a potential predictive biomarker for using SOCE inhibitors.

Reviewed by eLife

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

1. Zong-Shin Lin
2. Chiao-Chen Chung
3. Yu-Chia Liu
4. Chu-Han Chang
5. Hui-Chia Liu
6. Yung-Yi Liang
7. Teng-Le Huang
8. Tsung-Ming Chen
9. Che-Hsin Lee
10. Chih-Hsin Tang
11. Mien-Chie Hung
12. Ya-Huey Chen

• Curated by eLife

  eLife assessment

  In this study, Hung et al. address the biology and therapy of chondrosarcoma. The authors provided high-quality data that uncovered a new signaling axis, EZH2/hSULF1/c-Met, that promotes chondrosarcoma growth and progress. The authors also reported evidence showing that c-Met inhibition may be a plausible treatment option for chondrosarcoma. The findings are novel and translational and are of interest to cancer biologists and oncologists.

Reviewed by eLife

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

1. Samantha C Schwager
2. Katherine M Young
3. Lauren A Hapach
4. Caroline M Carlson
5. Jenna A Mosier
6. Tanner J McArdle
7. Wenjun Wang
8. Curtis Schunk
9. Anissa L Jayathilake
10. Madison E Bates
11. Francois Bordeleau
12. Marc A Antonyak
13. Richard A Cerione
14. Cynthia A Reinhart-King

• Curated by eLife

  eLife assessment

  The interesting manuscript shows that breast cancer cells that are poorly migratory in culture can be more metastatic in mice. This is due, at least in part, to the secretion of extracellular vesicles containing the the crosslinking enzyme Transglutaminase-2, which can activate fibroblasts in the tumours. These fibroblasts can then promote metastatic phenotypes. This study demonstrates how cancer cells can manipulate the cells around them in order to disseminate.

Reviewed by eLife

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

1. Jacob M Winter
2. Heidi L Fresenius
3. Corey N Cunningham
4. Peng Wei
5. Heather R Keys
6. Jordan Berg
7. Alex Bott
8. Tarun Yadav
9. Jeremy Ryan
10. Deepika Sirohi
11. Sheryl R Tripp
12. Paige Barta
13. Neeraj Agarwal
14. Anthony Letai
15. David M Sabatini
16. Matthew L Wohlever
17. Jared Rutter

• Curated by eLife

  eLife assessment

  The authors identify co-deletion of the mitochondrial AAA+ ATPase ATAD1 with the tumor suppressor PTEN as a factor modifying cancer prognosis, based on a new mechanism of increasing sensitivity to proteotoxic stress induced by proteasome inhibition. The authors also identify the mitochondrial E3 ubiquitin ligase MARCH5 as a gene whose deletion is synthetically lethal with ATAD1. These findings suggest that the use of proteasome-targeting agents may be useful in patients with tumors dually deleted for ATAD1 and PTEN. The study is based on convincing evidence, and makes an innovative contribution to the understanding of the biology of tumors with 10q23 deletions.

Reviewed by eLife

Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signaling

1. Mariah Farrell
2. Heather Fairfield
3. Michelle Karam
4. Anastasia D'Amico
5. Connor S Murphy
6. Carolyne Falank
7. Romanos Sklavenitis Pistofidi
8. Amanda Cao
9. Catherine R Marinac
10. Julie A Dragon
11. Lauren McGuinness
12. Carlos G Gartner
13. Reagan Di Iorio
14. Edward Jachimowicz
15. Victoria DeMambro
16. Calvin Vary
17. Michaela R Reagan

• Curated by eLife

  eLife assessment

  This manuscript will be of interest to researchers within the fields of haematological and bone oncology. It reveals a novel effect of FABP5 inhibition to reduce myeloma growth both in vitro and in vivo, with convincing supporting associations between FABP5 expression and survival in patients with myeloma.

Reviewed by eLife

Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

1. Tong Xu
2. Mathijs Verhagen
3. Rosalie Joosten
4. Wenjie Sun
5. Andrea Sacchetti
6. Leonel Munoz Sagredo
7. Véronique Orian-Rousseau
8. Riccardo Fodde

• Curated by eLife

  eLife assessment

  This study provides a valuable analysis of the splicing landscape in colon cancer cells that have properties intermediate between those typically found in primary cancers ("epithelial") and those that are spreading by metastasis ("mesenchymal"). The strength of evidence provided is wide ranging and convincing, and supports current ideas that changes in the way that RNA from particular genes is processed plays a key role in cancer spread.

Reviewed by eLife