Cancer Biology

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

1. Jinhai Deng
2. Teng Pan
3. Yourae Hong
4. Zaoqu Liu
5. Xingang Zhou
6. Zhengwen An
7. Lifeng Li
8. Giovanna Alfano
9. Gang Li
10. Luigi Dolcetti
11. Rachel Evans
12. Jose M Vicencio
13. Petra Vlckova
14. Yue Chen
15. James Monypenny
16. Camila Araujo De Carvalho Gomes
17. Kenrick Ng
18. Caitlin McCarthy
19. Xiaoping Yang
20. Zedong Hu
21. Joanna C. Porter
22. Christopher J Tape
23. Mingzhu Yin
24. Manuel Rodriguez-Justo
25. Sabine Tejpar
26. Richard Beatson
27. Tony Ng

Reviewed by Review Commons

Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

1. Jing-Ping Wang
2. Chun-Hao Hung
3. Yae-Huei Liou
4. Ching-Chen Liu
5. Kun-Hai Yeh
6. Keh-Yang Wang
7. Zheng-Sheng Lai
8. Biswanath Chatterjee
9. Tzu-Chi Hsu
10. Tung-Liang Lee
11. Yu-Chiau Shyu
12. Pei-Wen Hsiao
13. Liuh-Yow Chen
14. Trees-Juen Chuang
15. Chen-Hsin Albert Yu
16. Nan-Shih Liao
17. C-K James Shen

• Curated by eLife

  eLife assessment

  This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

Reviewed by eLife

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

1. Tristan Gicquel
2. Fabio Marchiano
3. Gabriela Reyes-Castellanos
4. Stephane Audebert
5. Luc Camoin
6. Bianca H Habermann
7. Benoit Giannesini
8. Alice Carrier

• Curated by eLife

  eLife assessment

  This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

Reviewed by eLife

N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

1. Dayoung Kim
2. James M. Olson
3. Jonathan A. Cooper

Reviewed by Review Commons

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

1. Fiona Grimm
2. Agustín Asuaje
3. Aakriti Jain
4. Mariana Silva dos Santos
5. Jens Kleinjung
6. Patrícia M. Nunes
7. Stefanie Gehrig
8. Louise Fets
9. James I. MacRae
10. Dimitrios Anastasiou

Reviewed by Review Commons

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

1. Tiantian Zhang
2. Sha Li
3. Yingcai Adrian Tan
4. Xiang Chen
5. Cheryl Zhang
6. Zhengming Chen
7. Bikash Mishra
8. Joseph HyungJoon Na
9. Soyoung Choi
10. Sandra J. Shin
11. Priyadarshan Damle
12. Kranthi Kumar Chougoni
13. Steven R. Grossman
14. Dunrui Wang
15. Xuejun Jiang
16. Yi Li
17. Erika Hissong
18. Yao-Tseng Chen
19. Jenny Z. Xiang
20. Yi-Chieh Nancy Du

Reviewed by Review Commons

CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

1. Silje Lier
2. Sara B Markusson
3. Anja Kocijancic
4. Martine Narum
5. Solveig O Lund
6. Bianka Böllering
7. Anuja Lipsa
8. Mirra L C Søegaard
9. Idun D Rein
10. Petra Santha
11. Preeti Jain
12. Anna Lång
13. Emma Lång
14. Niklas Meyer
15. Aparajita Dutta
16. Santosh Anand
17. Sugith B Badugu
18. Gaute J Nesse
19. Rune J Forstrøm
20. Arne Klungland
21. Ashish Anand
22. Steven M Pollard
23. Stig O Bøe
24. Johanne E Rinholm
25. Katrin B M Frauenknecht
26. Anna Golebiewska
27. Simone P Niclou
28. Kumar Somyajit
29. Mads Lerdrup
30. Deo P Pandey

Reviewed by Review Commons

Ferredoxin 1 is essential for embryonic development and lipid homeostasis

1. Shakur Mohibi
2. Yanhong Zhang
3. Vivian Perng
4. Mingyi Chen
5. Jin Zhang
6. Xinbin Chen

• Curated by eLife

  eLife assessment

  The findings provided by Mohibi et al. are important to the field of lipid metabolism and cancer and provide insight for an in vivo role of FDX1. The evidence is solid, utilizing multiple modalities and both in vitro and in vivo lines of investigation.

Reviewed by eLife

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

1. Qingyao Shang
2. Fei Ren
3. Kexin Feng
4. Chenxuan Yang
5. Shuangtao Zhao
6. Jiaxiang Liu
7. Xiyu Kang
8. Jiaxian Yue
9. Ruixuan Zhang
10. Xiangzhi Meng
11. Xiang Wang
12. Xin Wang

• Curated by eLife

  eLife assessment

  This study presents a useful finding on the role of GABRD and its downstream target CDK1 in the progression of breast cancer. The evidence supporting the claims of the authors is somewhat incomplete and the elaboration of the mechanistic details on GABARD/CDK1 regulation would have strengthened the study. The work will be of interest to clinicians and biologists working on breast cancer.

Reviewed by eLife

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

1. Jiamin Lin
2. Pingping Zhang
3. Wei Liu
4. Guorong Liu
5. Juan Zhang
6. Min Yan
7. Yuyou Duan
8. Na Yang

• Curated by eLife

  eLife assessment

  This study provides a valuable finding on the mechanistic connections between epithelial-mesenchymal transition (EMT) and lipid metabolism. The authors identified the ZEB2/ACSL4 axis as a newly discovered metastatic metabolic pathway that promotes both lipogenesis and fatty acid oxidation. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on cancer.

Reviewed by eLife