Cancer Biology

  1. Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

    1. Ryan R. Kawalerski
    2. Mariana Torrente Gonçalves
    3. Chun-Hao Pan
    4. Robert Tseng
    5. Lucia Roa-Peña
    6. Cindy V. Leiton
    7. Luke A. Torre-Healy
    8. Taryn Boyle
    9. Sumedha Chowdhury
    10. Natasha T. Snider
    11. Kenneth R. Shroyer
    12. Luisa F. Escobar-Hoyos

    • Curated by eLife

      eLife assessment

      The authors address the function of keratin 17 (K17), a marker of the most aggressive pancreatic ductal adenocarcinomas (PDACs). While this potentially useful study addresses a significant area of pancreatic cancer research, the lack of evidence demonstrating nuclear localization of K17 in human PDAC and the excessive reliance on a single cell line reduce the significance of the work. Moreover, the weak phenotypes of K17 phosphosite mutants provide incomplete support for the authors' mechanistic model.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Discovery of highly active kynureninases for cancer immunotherapy through protein language model

    1. Hyunuk Eom
    2. Sukhwan Park
    3. Kye Soo Cho
    4. Jihyeon Lee
    5. Hyunbin Kim
    6. Stephanie Kim
    7. Jinsol Yang
    8. Young-Hyun Han
    9. Juyong Lee
    10. Chaok Seok
    11. Myeong Sup Lee
    12. Woon Ju Song
    13. Martin Steinegger

    Reviewed by Arcadia Science

    9 evaluationsAppears in 1 listLatest version Latest activity

  5. Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

    1. Jinhai Deng
    2. Teng Pan
    3. Yourae Hong
    4. Zaoqu Liu
    5. Xingang Zhou
    6. Zhengwen An
    7. Lifeng Li
    8. Giovanna Alfano
    9. Gang Li
    10. Luigi Dolcetti
    11. Rachel Evans
    12. Jose M Vicencio
    13. Petra Vlckova
    14. Yue Chen
    15. James Monypenny
    16. Camila Araujo De Carvalho Gomes
    17. Kenrick Ng
    18. Caitlin McCarthy
    19. Xiaoping Yang
    20. Zedong Hu
    21. Joanna C. Porter
    22. Christopher J Tape
    23. Mingzhu Yin
    24. Manuel Rodriguez-Justo
    25. Sabine Tejpar
    26. Richard Beatson
    27. Tony Ng

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

    1. Dayoung Kim
    2. James M. Olson
    3. Jonathan A. Cooper

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

    1. Fiona Grimm
    2. Agustín Asuaje
    3. Aakriti Jain
    4. Mariana Silva dos Santos
    5. Jens Kleinjung
    6. Patrícia M. Nunes
    7. Stefanie Gehrig
    8. Louise Fets
    9. James I. MacRae
    10. Dimitrios Anastasiou

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

    1. Tiantian Zhang
    2. Sha Li
    3. Yingcai Adrian Tan
    4. Xiang Chen
    5. Cheryl Zhang
    6. Zhengming Chen
    7. Bikash Mishra
    8. Joseph HyungJoon Na
    9. Soyoung Choi
    10. Sandra J. Shin
    11. Priyadarshan Damle
    12. Kranthi Kumar Chougoni
    13. Steven R. Grossman
    14. Dunrui Wang
    15. Xuejun Jiang
    16. Yi Li
    17. Erika Hissong
    18. Yao-Tseng Chen
    19. Jenny Z. Xiang
    20. Yi-Chieh Nancy Du

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity
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