Cancer Biology

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

1. Laura M Sipe
2. Mehdi Chaib
3. Emily B Korba
4. Heejoon Jo
5. Mary Camille Lovely
6. Brittany R Counts
7. Ubaid Tanveer
8. Jeremiah R Holt
9. Jared C Clements
10. Neena A John
11. Deidre Daria
12. Tony N Marion
13. Margaret S Bohm
14. Radhika Sekhri
15. Ajeeth K Pingili
16. Bin Teng
17. James A Carson
18. D Neil Hayes
19. Matthew J Davis
20. Katherine L Cook
21. Joseph F Pierre
22. Liza Makowski

• Curated by eLife

  Evaluation Summary:

  This study investigates on how weight loss by bariatric surgery or weight-matched dietary intervention impairs breast cancer growth as well as immunotherapy. This study can potentially provide some therapeutic intervention strategies on combining vertical sleeve gastrectomy and immunotherapy in treating breast cancer.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity

1. Marcelo Lima Ribeiro
2. Núria Profitós-Pelejà
3. Juliana Carvalho Santos
4. Pedro Blecua
5. Diana Reyes Garau
6. Marc Armengol
7. Miranda Fernández-Serrano
8. Hari P. Miskin
9. Francesc Bosch
10. Manel Esteller
11. Emmanuel Normant
12. Gael Roué

• Curated by eLife

  Evaluation Summary:

  Ribeiro M et al investigate the ability of a novel bispecific CD19-CD47 antibody to enhance the cell mediated killing mediated by existing drug combinations - anti-CD20 plus PIK3d/CK1E inhibitor. The novelty of this study is the restriction to CD19 positive lymphoma cells, thus potentially avoiding toxicity to non-lymphoma lineages, and the gene expression profiling to identify up regulation of GPR183 after combined treatment of CD19/47 plus CD20/PI3K/CK1E vs CD19/47 alone. Genetic and drug studies suggest that GPR183 is essential for the full activity of the triplet drug combination.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

1. Wesley L Cai
2. Jocelyn Fang-Yi Chen
3. Huacui Chen
4. Emily Wingrove
5. Sarah J Kurley
6. Lok Hei Chan
7. Meiling Zhang
8. Anna Arnal-Estape
9. Minghui Zhao
10. Amer Balabaki
11. Wenxue Li
12. Xufen Yu
13. Ethan D Krop
14. Yali Dou
15. Yansheng Liu
16. Jian Jin
17. Thomas F Westbrook
18. Don X Nguyen
19. Qin Yan

• Curated by eLife

  Evaluation Summary:

  The authors of this manuscript, which is of interest to the cancer community, identify the chromatin regulator WDR5 as a possible new drug target in triple negative breast cancer. Targeted therapeutics for this patient population are of high scientific and clinical interest, and the authors provide a compelling case that co-targeting WDR5 along with mTOR provides a promising new therapeutic strategy.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

1. Qing Ma
2. Liuyi Yang
3. Karen Tolentino
4. Guiping Wang
5. Yang Zhao
6. Ulrike M Litzenburger
7. Quanming Shi
8. Lin Zhu
9. Chen Yang
10. Huiyuan Jiao
11. Feng Zhang
12. Rui Li
13. Miao-Chih Tsai
14. Jun-An Chen
15. Ian Lai
16. Hong Zeng
17. Lingjie Li
18. Howard Y Chang

• Curated by eLife

  Evaluation Summary:

  The long non-coding RNA HOTAIR has been widely reported to be overexpressed in many cancers, including breast cancer, and is strongly associated with disease progression and poor patient outcomes. A valuable new mouse model was developed for studying the functional effects of overexpressing HOTAIR and the mechanism of action of HOTAIR and used to demonstrate overexpression of HOTAIR promoted breast cancer metastasis to the lung. The mouse model and the conclusions will be of interest to researchers interested in improving treatment for breast cancer.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

1. Deborah Fanfone
2. Zhichong Wu
3. Jade Mammi
4. Kevin Berthenet
5. David Neves
6. Kathrin Weber
7. Andrea Halaburkova
8. François Virard
9. Félix Bunel
10. Catherine Jamard
11. Hector Hernandez-Vargas
12. Stephen WG Tait
13. Ana Hennino
14. Gabriel Ichim

• Curated by eLife

  Evaluation Summary:

  The study proposes that confined migration renders breast cancer cells resistant to apoptosis via NFkappaB-dependent mechanisms. The technical aspects of the study are impressive and experiments are very well performed and demonstrate the value of mimetic bioengineering approaches, but the postulated central premise would require more rigorous support.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

1. Shreoshi Sengupta
2. Mainak Mondal
3. Kaval Reddy Prasasvi
4. Arani Mukherjee
5. Prerna Magod
6. Serge Urbach
7. Dinorah Friedmann-Morvinski
8. Philippe Marin
9. Kumaravel Somasundaram

• Curated by eLife

  Evaluation Summary:

  The authors shed light on the role that non-cancer stem cell exerts in promoting cancer progression, revealing that non-cancer stem cell-secreted fibromodulin is crucial in mediating angiogenesis in glioma via integrin-dependent Notch signaling. The logic is smooth and clear and the results are solid, and the findings should be interesting for those who are expertized in the field of cancer biology and cancer stem cell.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

1. Ngoc Lan Tran
2. Lorena Maria Ferreira
3. Blanca Alvarez-Moya
4. Valentina Buttiglione
5. Barbara Ferrini
6. Paola Zordan
7. Andrea Monestiroli
8. Claudio Fagioli
9. Eugenia Bezzecchi
10. Giulia Maria Scotti
11. Antonio Esposito
12. Riccardo Leone
13. Chiara Gnasso
14. Andrea Brendolan
15. Luca G Guidotti
16. Giovanni Sitia

Reviewed by Review Commons

Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

1. James Boot
2. Gabriel Rosser
3. Dailya Kancheva
4. Claire Vinel
5. Yau Mun Lim
6. Nicola Pomella
7. Xinyu Zhang
8. Loredana Guglielmi
9. Denise Sheer
10. Michael Barnes
11. Sebastian Brandner
12. Sven Nelander
13. Kiavash Movahedi
14. Silvia Marino

• Curated by eLife

  Evaluation Summary:

  Glioblastoma is a challenging disease with a high level of heterogeneity. Here the authors use global methylation profiling of tumor-initiating cells and matched iNSCs and identify a subgroup of hypomethylated tumors with an astrocytic phenotype. Understanding heterogeneity in glioblastoma is a major challenge, and the identification of alterations of functional and clinical impact is of importance to the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple‐negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

1. Yunting Jian
2. Lingzhi Kong
3. Hongyi Xu
4. Yawei Shi
5. Xinjian Huang
6. Wenjing Zhong
7. Shumei Huang
8. Yue Li
9. Dongni Shi
10. Yunyun Xiao
11. Muwen Yang
12. Siqi Li
13. Xiangfu Chen
14. Ying Ouyang
15. Yameng Hu
16. Xin Chen
17. Libing Song
18. Runyi Ye
19. Weidong Wei

• Curated by eLife

  Evaluation Summary:

  The manuscript presents data that high expression of Protein Phosphatase 1 (PP1) inhibitor in triple-negative breast cancer contributes to poor outcomes by downregulation of an important kinase, GSK3β. The study clearly demonstrates that changes in PPP1R14C expression alter the behaviour of the studied cancer cells and mouse models and proposes a mechanism linking PP1 inhibitor to GSK3β. If this mechanism were substantiated, this would enhance our understanding of the pathophysiology of this important disease and might suggest new treatment options.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis

1. Limin Jiang
2. Hui Yu
3. Scott Ness
4. Peng Mao
5. Fei Guo
6. Jijun Tang
7. Yan Guo

• Curated by eLife

  Evaluation Summary:

  This paper provides a comprehensive co-mutation analysis of over 30 thousand cancer patients and 1700+ cancer cell lines to identify associations with prognosis and drug resistance that could have translational value for clinical practice. Once validated, it would provide a useful framework for precision oncology.

  “(This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.”.)

Reviewed by eLife