Cancer Biology

Cancer-associated fibroblasts promote drug resistance in ALK -driven lung adenocarcinoma cells by upregulating lipid biosynthesis

1. Ann-Kathrin Daum
2. Lisa Schlicker
3. Marc A. Schneider
4. Thomas Muley
5. Ursula Klingmüller
6. Almut Schulze
7. Michael Thomas
8. Petros Christopoulos
9. Holger Sültmann

Reviewed by Review Commons

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy

1. Abrar Choudhury
2. Martha A. Cady
3. Calixto-Hope G. Lucas
4. Hinda Najem
5. Joanna J. Phillips
6. Brisa Palikuqi
7. Naomi Zakimi
8. Tara Joseph
9. Janeth Ochoa Birrueta
10. William C. Chen
11. Nancy Ann Oberheim Bush
12. Shawn L. Hervey-Jumper
13. Ophir D. Klein
14. Christine M. Toedebusch
15. Craig M. Horbinski
16. Stephen T. Magill
17. Aparna Bhaduri
18. Arie Perry
19. Peter J. Dickinson
20. Amy B. Heimberger
21. Alan Ashworth
22. Elizabeth E. Crouch
23. David R. Raleigh

Reviewed by PREreview

Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning

1. Gehad Youssef
2. Luke Gammon
3. Leah Ambler
4. Sophia Lunetto
5. Alice Scemama
6. Hannah Cottom
7. Kim Piper
8. Ian C Mackenzie
9. Michael P Philpott
10. Adrian Biddle

• Curated by eLife

  eLife assessment

  This is a valuable study that convincingly demonstrates that quantification of EpCAM+/CD24+/Vimentin+ cells in the stroma of human oral cancers followed by machine learning algorithms can be used as a prognostic indicator of metastasis.

Reviewed by eLife

Molecular portraits of colorectal cancer morphological regions

1. Eva Budinská
2. Martina Hrivňáková
3. Tina Catela Ivkovic
4. Marie Madrzyk
5. Rudolf Nenutil
6. Beatrix Bencsiková
7. Dagmar Al Tukmachi
8. Michaela Ručková
9. Lenka Zdražilová Dubská
10. Ondřej Slabý
11. Josef Feit
12. Mihnea-Paul Dragomir
13. Petra Borilova Linhartova
14. Sabine Tejpar
15. Vlad Popovici

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the putative molecular patterns underlying characteristic morphological regions observed in colorectal cancer (CRC). The authors provide a morphological framework through which clinicians might improve the performance of molecular signatures and consequently predict the clinical response of patients with better accuracy. The evidence supporting the claims of the authors is solid. The work will be of interest to clinicians and cancer biologists working in the field of CRC.

Reviewed by eLife

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

1. Weirong Kang
2. Yibo Fan
3. Yinxiao Du
4. Elina A. Tonkova
5. Yi-Hsin Hsu
6. Kel Vin Tan
7. Stephanie Alexander
8. Bin Sheng Wong
9. Haocheng Yang
10. Jingyuan Luo
11. Kuo Yao
12. Jiayao Yang
13. Xin Hu
14. Tingting Liu
15. Yu Gan
16. Jian Zhang
17. Jean J. Zhao
18. Konstantinos Konstantopoulos
19. Peter Friedl
20. Pek Lan Khong
21. Aiping Lu
22. Mien-Chie Hung
23. Michael B. Brenner
24. Jeffrey E. Segall
25. Zhizhan Gu

• Curated by eLife

  eLife assessment

  This paper presents a series of experiments investigating the role of cadherin-11 mediated interactions between cancer cells and fibroblasts in metastasis using updated 3D cell co-invasion assays. The primarily descriptive data are a valuable contribution to our understanding of the nature of cross cell-type interactions in metastasis, but are incomplete with respect to the far-reaching conclusions about the central role cadherin-11, especially given the complex nature of the phenotype and the need to better contextualize these observations in a complete picture of metastasis.

Reviewed by eLife

Reduced S-nitrosylation of TGFβ1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast

1. Joshua Letson
2. Gang Ren
3. Xunzhen Zheng
4. Osama Sweef
5. Yalitza Lopes Corcino
6. Saori Furuta

Reviewed by PREreview

Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

1. Dan-Dan Zou
2. Ya-Zhou Sun
3. Xin-Jie Li
4. Wen-Juan Wu
5. Dan Xu
6. Yu-Tong He
7. Jue Qi
8. Ying Tu
9. Yang Tang
10. Yun-Hua Tu
11. Xiao-Li Wang
12. Xing Li
13. Feng-Yan Lu
14. Ling Huang
15. Heng Long
16. Li He
17. Xin Li

• Curated by eLife

  eLife assessment

  This important study delineates the molecular changes driving the progression from actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC). Using state-of-the-art single-cell RNA profiling of 138,982 cells from 13 samples of six patients including AK, squamous cell carcinoma in situ (SCCIS), cSCC, and their matched normal tissues, thus covering comprehensive clinical courses of cSCC, the authors provide an invaluable data resource. This study identified several previously unreported and interesting candidate genes involved in different stages of the malignant progression of skin neoplasias, which have been validated in situ, and partially in vitro. Although data analysis needs improvement and comparison to other published data sets to fully support the claims and conclusions, these findings substantially advance our understanding of the molecular changes leading to skin cancer.

Reviewed by eLife

Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

1. Huan Fang
2. Wenlong Ren
3. Qiuxia Cui
4. Huichun Liang
5. Chuanyu Yang
6. Wenjing Liu
7. Xinye Wang
8. Xue Liu
9. Yujie Shi
10. Jing Feng
11. Ceshi Chen

• Curated by eLife

  eLife assessment

  This study presents a rather valuable finding that IQGAP1 interacts with TNFAIP2, which activates Rac1 to promote drug resistance in TNBC. The evidence supporting the claims of the authors is quite solid. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife

shRNA drop-out screen identifies BRD4 targeting transcription from RNA polymerase II system to activate β-catenin to promote soft-tissue tumor proliferations

1. Sylvia Y. Sun
2. Vlad Tsiperson

Reviewed by PREreview

Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

1. Kota Kaneko
2. Yan Liang
3. Qing Liu
4. Shuo Zhang
5. Alexander Scheiter
6. Dan Song
7. Gen-Sheng Feng

• Curated by eLife

  eLife assessment

  This important study was designed to examine the bypass of Ras/Erk signaling defects that enable limited regeneration in a mouse model of hepatic regeneration. This hepatocyte proliferation is associated with the expression by groups of cells of mRNA-loaded CD133+ intracellular vesicles that mediate an intercellular signaling pathway that supports proliferation. These are new observations, supported by convincing data, that have broad significance to the fields of regeneration and cancer.

Reviewed by eLife