Cancer Biology

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

1. Weirong Kang
2. Yibo Fan
3. Yinxiao Du
4. Elina A. Tonkova
5. Yi-Hsin Hsu
6. Kel Vin Tan
7. Stephanie Alexander
8. Bin Sheng Wong
9. Haocheng Yang
10. Jingyuan Luo
11. Kuo Yao
12. Jiayao Yang
13. Xin Hu
14. Tingting Liu
15. Yu Gan
16. Jian Zhang
17. Jean J. Zhao
18. Konstantinos Konstantopoulos
19. Peter Friedl
20. Pek Lan Khong
21. Aiping Lu
22. Mien-Chie Hung
23. Michael B. Brenner
24. Jeffrey E. Segall
25. Zhizhan Gu

• Curated by eLife

  eLife assessment

  This paper presents a series of experiments investigating the role of cadherin-11 mediated interactions between cancer cells and fibroblasts in metastasis using updated 3D cell co-invasion assays. The primarily descriptive data are a valuable contribution to our understanding of the nature of cross cell-type interactions in metastasis, but are incomplete with respect to the far-reaching conclusions about the central role cadherin-11, especially given the complex nature of the phenotype and the need to better contextualize these observations in a complete picture of metastasis.

Reviewed by eLife

Reduced S-nitrosylation of TGFβ1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast

1. Joshua Letson
2. Gang Ren
3. Xunzhen Zheng
4. Osama Sweef
5. Yalitza Lopes Corcino
6. Saori Furuta

Reviewed by PREreview

Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

1. Dan-Dan Zou
2. Ya-Zhou Sun
3. Xin-Jie Li
4. Wen-Juan Wu
5. Dan Xu
6. Yu-Tong He
7. Jue Qi
8. Ying Tu
9. Yang Tang
10. Yun-Hua Tu
11. Xiao-Li Wang
12. Xing Li
13. Feng-Yan Lu
14. Ling Huang
15. Heng Long
16. Li He
17. Xin Li

• Curated by eLife

  eLife assessment

  This important study delineates the molecular changes driving the progression from actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC). Using state-of-the-art single-cell RNA profiling of 138,982 cells from 13 samples of six patients including AK, squamous cell carcinoma in situ (SCCIS), cSCC, and their matched normal tissues, thus covering comprehensive clinical courses of cSCC, the authors provide an invaluable data resource. This study identified several previously unreported and interesting candidate genes involved in different stages of the malignant progression of skin neoplasias, which have been validated in situ, and partially in vitro. Although data analysis needs improvement and comparison to other published data sets to fully support the claims and conclusions, these findings substantially advance our understanding of the molecular changes leading to skin cancer.

Reviewed by eLife

Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

1. Huan Fang
2. Wenlong Ren
3. Qiuxia Cui
4. Huichun Liang
5. Chuanyu Yang
6. Wenjing Liu
7. Xinye Wang
8. Xue Liu
9. Yujie Shi
10. Jing Feng
11. Ceshi Chen

• Curated by eLife

  eLife assessment

  This study presents a rather valuable finding that IQGAP1 interacts with TNFAIP2, which activates Rac1 to promote drug resistance in TNBC. The evidence supporting the claims of the authors is quite solid. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife

shRNA drop-out screen identifies BRD4 targeting transcription from RNA polymerase II system to activate β-catenin to promote soft-tissue tumor proliferations

1. Sylvia Y. Sun
2. Vlad Tsiperson

Reviewed by PREreview

Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit

1. Kota Kaneko
2. Yan Liang
3. Qing Liu
4. Shuo Zhang
5. Alexander Scheiter
6. Dan Song
7. Gen-Sheng Feng

• Curated by eLife

  eLife assessment

  This important study was designed to examine the bypass of Ras/Erk signaling defects that enable limited regeneration in a mouse model of hepatic regeneration. This hepatocyte proliferation is associated with the expression by groups of cells of mRNA-loaded CD133+ intracellular vesicles that mediate an intercellular signaling pathway that supports proliferation. These are new observations, supported by convincing data, that have broad significance to the fields of regeneration and cancer.

Reviewed by eLife

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

1. Irene Casanova-Salas
2. Daniel Aguilar
3. Sarai Cordoba-Terreros
4. Laura Agundez
5. Julian Brandariz
6. Nicolas Herranz
7. Alba Mas
8. Macarena Gonzalez
9. Rafael Morales-Barrera
10. Alexandre Sierra
11. Mario Soriano-Navarro
12. Pablo Cresta
13. Gisela Mir
14. Sara Simonetti
15. Gonçalo Rodrigues
16. Sara Arce-Gallego
17. Luisa Delgado-Serrano
18. Irene Agustí
19. Elena Castellano-Sanz
20. Richard Mast
21. Matias de Albert
22. Ana Celma
23. Anna Santamaria
24. Lucila Gonzalez
25. Natalia Castro
26. Maria del Mar Suanes
27. Javier Hernández-Losa
28. Lara Nonell
29. Hector Peinado
30. Joan Carles
31. Joaquin Mateo

Reviewed by PREreview

Identifying targetable metabolic dependencies across colorectal cancer progression

1. Danny N. Legge
2. Tracey J. Collard
3. Ewelina Stanko
4. Ashley J. Hoskin
5. Amy K. Holt
6. Caroline J. Bull
7. Madhu Kollareddy
8. Jake Bellamy
9. Sarah Groves
10. Eric H. Ma
11. Emma Hazelwood
12. David Qualtrough
13. Borko Amulic
14. Karim Malik
15. Ann C. Williams
16. Nicholas Jones
17. Emma E. Vincent

Reviewed by Review Commons

Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells

1. Ann-Kathrin Herzfeldt
2. Marta Puig Gamez
3. Eva Martin
4. Lukasz Miloslaw Boryn
5. Praveen Baskaran
6. Heinrich J Huber
7. Michael Schuler
8. John E Park
9. Lee Kim Swee

• Curated by eLife

  eLife assessment

  This important research uses complementary CRISPR screening strategies to reveal novel pathways that prevent T cells from killing tumor cells. The evidence presented to support the claims is solid, although some additional assays defining the features of these novel pathways and their clinical relevance are still required. Overall, this work will be of broad interest to immunologists, cancer biologists, and those interested in cell adhesion and cell-cell communication.

Reviewed by eLife

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

1. Xingyun Yang
2. Mara Artibani
3. Yongcheng Jin
4. Aneesh Aggarwal
5. Yujia Zhang
6. Sandra Muñoz-Galvan
7. Ellina Mikhailova
8. Lena Rai
9. Nobina Mukherjee
10. Ravinash Krishna Kumar
11. Ashwag Albukhari
12. Linna Zhou
13. Ahmed Ashour Ahmed
14. Hagan Bayley

Reviewed by PREreview