1. Molecular classification and tumor microenvironment characteristics in pheochromocytomas

    This article has 13 authors:
    1. Sen Qin
    2. Yawei Xu
    3. Shimiao Yu
    4. Wencong Han
    5. Shiheng Fan
    6. Wenxiang Ai
    7. Kenan Zhang
    8. Yizhou Wang
    9. Xuehong Zhou
    10. Qi Shen
    11. Kan Gong
    12. Luyang Sun
    13. Zheng Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study advances our understanding of the potential therapeutic strategies for the treatment of pheochromocytomas using single-cell transcriptomics. The authors propose a new molecular classification criterion based on the characterization of tumor microenvironmental features, based on solid evidence. The work, which could be improved further through delineating the choice of the PASS scoring system, will be of broad interest to clinicians, medical researchers, and scientists working in the field of pheochromocytoma.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Discovery of highly active kynureninases for cancer immunotherapy through protein language model

    This article has 13 authors:
    1. Hyunuk Eom
    2. Sukhwan Park
    3. Kye Soo Cho
    4. Jihyeon Lee
    5. Hyunbin Kim
    6. Stephanie Kim
    7. Jinsol Yang
    8. Young-Hyun Han
    9. Juyong Lee
    10. Chaok Seok
    11. Myeong Sup Lee
    12. Woon Ju Song
    13. Martin Steinegger

    Reviewed by Arcadia Science

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

    This article has 27 authors:
    1. Jinhai Deng
    2. Teng Pan
    3. Yourae Hong
    4. Zaoqu Liu
    5. Xingang Zhou
    6. Zhengwen An
    7. Lifeng Li
    8. Giovanna Alfano
    9. Gang Li
    10. Luigi Dolcetti
    11. Rachel Evans
    12. Jose M Vicencio
    13. Petra Vlckova
    14. Yue Chen
    15. James Monypenny
    16. Camila Araujo De Carvalho Gomes
    17. Kenrick Ng
    18. Caitlin McCarthy
    19. Xiaoping Yang
    20. Zedong Hu
    21. Joanna C. Porter
    22. Christopher J Tape
    23. Mingzhu Yin
    24. Manuel Rodriguez-Justo
    25. Sabine Tejpar
    26. Richard Beatson
    27. Tony Ng

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

    This article has 17 authors:
    1. Jing-Ping Wang
    2. Chun-Hao Hung
    3. Yae-Huei Liou
    4. Ching-Chen Liu
    5. Kun-Hai Yeh
    6. Keh-Yang Wang
    7. Zheng-Sheng Lai
    8. Biswanath Chatterjee
    9. Tzu-Chi Hsu
    10. Tung-Liang Lee
    11. Yu-Chiau Shyu
    12. Pei-Wen Hsiao
    13. Liuh-Yow Chen
    14. Trees-Juen Chuang
    15. Chen-Hsin Albert Yu
    16. Nan-Shih Liao
    17. C-K James Shen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

    This article has 8 authors:
    1. Tristan Gicquel
    2. Fabio Marchiano
    3. Gabriela Reyes-Castellanos
    4. Stephane Audebert
    5. Luc Camoin
    6. Bianca H Habermann
    7. Benoit Giannesini
    8. Alice Carrier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study uses a mouse model of pancreatic cancer to examine mitochondrial mass and structure in atrophying muscle along with aspects of mitochondrial metabolism in the same tissue. Most relevant are the solid transcriptomics and proteomics approaches to map out related changes in gene expression networks in muscle during cancer cachexia.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. N-cadherin dynamically regulates pediatric glioma cell migration in complex environments

    This article has 3 authors:
    1. Dayoung Kim
    2. James M. Olson
    3. Jonathan A. Cooper

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

    This article has 10 authors:
    1. Fiona Grimm
    2. Agustín Asuaje
    3. Aakriti Jain
    4. Mariana Silva dos Santos
    5. Jens Kleinjung
    6. Patrícia M. Nunes
    7. Stefanie Gehrig
    8. Louise Fets
    9. James I. MacRae
    10. Dimitrios Anastasiou

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

    This article has 20 authors:
    1. Tiantian Zhang
    2. Sha Li
    3. Yingcai Adrian Tan
    4. Xiang Chen
    5. Cheryl Zhang
    6. Zhengming Chen
    7. Bikash Mishra
    8. Joseph HyungJoon Na
    9. Soyoung Choi
    10. Sandra J. Shin
    11. Priyadarshan Damle
    12. Kranthi Kumar Chougoni
    13. Steven R. Grossman
    14. Dunrui Wang
    15. Xuejun Jiang
    16. Yi Li
    17. Erika Hissong
    18. Yao-Tseng Chen
    19. Jenny Z. Xiang
    20. Yi-Chieh Nancy Du

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

    This article has 21 authors:
    1. Silje Lier
    2. Solveig Osnes Lund
    3. Anuja Lipsa
    4. Katrin B. M. Frauenknecht
    5. Idun Dale Rein
    6. Preeti Jain
    7. Anna Ulrika Lång
    8. Emma Helena Lång
    9. Niklas Meyer
    10. Aparajita Dutta
    11. Santosh Anand
    12. Gaute Johan Nesse
    13. Rune Forstrøm Johansen
    14. Arne Klungland
    15. Johanne Egge Rinholm
    16. Stig Ove Bøe
    17. Ashish Anand
    18. Steven Michael Pollard
    19. Simone P. Niclou
    20. Mads Lerdrup
    21. Deo Prakash Pandey

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Ferredoxin 1 is essential for embryonic development and lipid homeostasis

    This article has 6 authors:
    1. Shakur Mohibi
    2. Yanhong Zhang
    3. Vivian Perng
    4. Mingyi Chen
    5. Jin Zhang
    6. Xinbin Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The findings provided by Mohibi et al. are important to the field of lipid metabolism and cancer and provide insight for an in vivo role of FDX1. The evidence is solid, utilizing multiple modalities and both in vitro and in vivo lines of investigation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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