Cancer Biology

Prognostic Significance of preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP in Patients with Endometrial cancer

1. Zi-hao Wang
2. Yun-zheng Zhang
3. Shu-wen Ge
4. Luhe-Shan
5. Bo Wang
6. Zi-yu Zhang
7. Qi-jun Wu
8. Xiao-xin Ma

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on prognostic values of serum CA125, CEA, and AFP for predicting patient outcomes of endometrial cancer. The evidence supporting the claims of the authors is solid, although inclusion of detailed discussion of present results with prior documented findings would have strengthened the study. The work will be of interest to scientists working on endometrial cancer.

Reviewed by eLife

Post-transcriptional control drives Aurora kinase A expression in human cancers

1. Roberta Cacioppo
2. Deniz Rad
3. Giulia Pagani
4. Paolo Gandellini
5. Catherine Lindon

Reviewed by Review Commons

Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

1. Khanh N. Dinh
2. Monika K. Kurpas
3. Marek Kimmel

• Curated by eLife

  eLife assessment

  This study uses numerical simulations to characterize and compare variants of two widely used mathematical models and then applies those models to inferring evolutionary parameters from breast cancer data. The copious numerical results will be of some interest to mathematical biologists working with similar models. The finding that many breast cancer mutations are mildly deleterious is valuable but the evidence supporting this claim is incomplete because the mathematical modelling and statistical methods are insufficiently justified and inadequately validated.

Reviewed by eLife

STIL overexpression shortens lifespan and reduces tumor formation in mice

1. Amira-Talaat Moussa
2. Marco R. Cosenza
3. Timothy Wohlfromm
4. Katharina Brobeil
5. Anthony Hill
6. Annarita Patrizi
7. Karin Müller-Decker
8. Tim Holland-Letz
9. Anna Jauch
10. Bianca Kraft
11. Alwin Krämer

Reviewed by Review Commons