Cancer Biology

Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

1. Rui Zhang
2. Qingxi Liu
3. Sa Zhou
4. Hongpeng He
5. Mingfeng Zhao
6. Wenjian Ma

• Curated by eLife

  eLife assessment

  This study provides potentially important insights into the role of mesenchymal stem cells in CAR-T therapy, and suggest that the STC1 gene could be a key factor in influencing the efficacy of this treatment. This finding has the potential to improve current therapeutic strategies based on cell therapy and may indicate new biology related to how mesenchymal stem cells affect the immune state within the tumor microenvironment. Further research is necessary to clarify the signaling pathways, but the data presented by the authors are generally well-supported and convincing.

Reviewed by eLife

Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

1. Lisa Goebel
2. Tonia Kirschner
3. Sandra Koska
4. Amrita Rai
5. Petra Janning
6. Stefano Maffini
7. Helge Vatheuer
8. Paul Czodrowski
9. Roger S Goody
10. Matthias P Müller
11. Daniel Rauh

• Curated by eLife

  eLife assessment

  The authors present interesting information regarding the possibility of targeting the oncogenic K-Ras(G13C) mutant with nucleotide competitors. The experiments represent a solid support of the claims and show that this approach can work despite concerns about the high affinity of GTP and its high cellular concentration. These results will be of high interest for all working in the Ras field and in targeting oncogenes with small molecules. A weakness of the manuscript is the lack of direct physiological insights.

Reviewed by eLife

Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

1. Elena Tomas Bort
2. Megan D Joseph
3. Qiaoying Wang
4. Edward P Carter
5. Nicolas J Roth
6. Jessica Gibson
7. Ariana Samadi
8. Hemant M Kocher
9. Sabrina Simoncelli
10. Peter J McCormick
11. Richard P Grose

Reviewed by Review Commons

A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma

1. Haley R Noonan
2. Alexandra M Thornock
3. Julia Barbano
4. Michael E Xifaras
5. Chloe S Baron
6. Song Yang
7. Katherine Koczirka
8. Alicia M McConnell
9. Leonard I Zon

• Curated by eLife

  eLife assessment

  This study presents a valuable enhancer reporter of TGFb signaling in melanoma that has a conserved function in both human cell lines and zebrafish. The reporter data is solid and provides interesting insights into TGFb targets in melanoma. However, the model that macrophages preferentially phagocytose certain subsets of melanoma cells is still incomplete, and more data will be needed before this process is clearly understood.

Reviewed by eLife

Two opposing gene expression patterns within ATRX aberrant neuroblastoma

1. Michael R. van Gerven
2. Linda Schild
3. Jennemiek van Arkel
4. Bianca Koopmans
5. Luuk A. Broeils
6. Loes A. M. Meijs
7. Romy van Oosterhout
8. Max M. van Noesel
9. Jan Koster
10. Sander R. van Hooff
11. Jan J. Molenaar
12. Marlinde van den Boogaard

Reviewed by Review Commons

Dalpiciclib partially abrogates ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer

1. Jiawen Bu
2. Yixiao Zhang
3. Nan Niu
4. Kewei Bi
5. Lisha Sun
6. Xinbo Qiao
7. Yimin Wang
8. Yinan Zhang
9. Xiaofan Jiang
10. Dan Wang
11. Qingtian Ma
12. Huajun Li
13. Caigang Liu

• Curated by eLife

  eLife assessment

  This study presents a valuable finding that the combined use of pyrotinib with dalpiciclib exhibits better therapeutic efficacy against HER2+/HR+ breast cancer cells. The evidence supporting the claims of the authors is rather solid. The work will be of interest to medical biologists and clinical doctors working on breast cancer.

Reviewed by eLife

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

1. Kimberly J Morgan
2. Karen Doggett
3. Fansuo Geng
4. Stephen Mieruszynski
5. Lachlan Whitehead
6. Kelly A Smith
7. Benjamin M Hogan
8. Cas Simons
9. Gregory J Baillie
10. Ramyar Molania
11. Anthony T Papenfuss
12. Thomas E Hall
13. Elke A Ober
14. Didier YR Stainier
15. Zhiyuan Gong
16. Joan K Heath

• Curated by eLife

  eLife assessment

  Here, Morgan and colleagues report a novel synthetic lethal interaction between nucleoporin inhibition and KRAS-driven hepatocyte hyperproliferation. The authors show that nucleoporin inhibitor treatment or heterozygosity of nucleoporin genes (ahctf1 and/or ranbp2) suppresses KRAS-driven zebrafish larval liver overgrowth, providing impetus for developing Nup inhibitors as hepatocellular carcinoma treatment. Their data provide insights into the consequences of nucleoporin inhibition in cancer, demonstrating that disrupting ahctf1 decreases proliferation and promotes apoptosis by impairing nuclear pore formation and mitotic spindle assembly through a mechanism that may be at least partially dependent on tp53.

Reviewed by eLife

RAS and PP2A activities converge on epigenetic gene regulation

1. Anna Aakula
2. Mukund Sharma
3. Francesco Tabaro
4. Reetta Nätkin
5. Jesse Kamila
6. Henrik Honkanen
7. Matthieu Schapira
8. Cheryl Arrowsmith
9. Matti Nykter
10. Jukka Westermarck

Reviewed by Review Commons

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

1. Kexin Li
2. Qingji Huo
3. Nathan H Dimmitt
4. Guofan Qu
5. Junjie Bao
6. Pankita H Pandya
7. M Reza Saadatzadeh
8. Khadijeh Bijangi-Vishehsaraei
9. Melissa A Kacena
10. Karen E Pollok
11. Chien-Chi Lin
12. Bai-Yan Li
13. Hiroki Yokota

• Curated by eLife

  eLife assessment

  There are no known effective treatments available to date for the treatment of osteosarcomas, the earliest identified bone cancer that can spread to other tissues. In this study, the authors have used novel approaches to identify calreticulin and procollagen C-endopeptidase enhancer (PCOLCE) as osteosarcoma tumor suppressor proteins that inhibit osteosarcoma growth both in animal and in vitro cell culture models. These important findings may provide a basis for the future development of more efficient targeted therapies for the treatment of osteosarcomas.

Reviewed by eLife

Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma

1. Takuya Kato
2. Robert P Jenkins
3. Stefanie Derzsi
4. Melda Tozluoglu
5. Antonio Rullan
6. Steven Hooper
7. Raphaël AG Chaleil
8. Holly Joyce
9. Xiao Fu
10. Selvam Thavaraj
11. Paul A Bates
12. Erik Sahai

• Curated by eLife

  eLife assessment

  This study addresses several gaps that are evident with regards to cancer cell invasion in tissue. The approaches taken by this group encompassing mathematical modeling and experimental procedures are for the most part rigorous. The study is deemed as of high potential impact.

Reviewed by eLife