Biophysics

Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

1. Richard J Lindsay
2. Abhilash Sahoo
3. Rafael Giordano Viegas
4. Vitor BP Leite
5. Philip A Wigge
6. Sonya M Hanson

• Curated by eLife

  eLife Assessment

  In this potentially valuable computational study, the authors conducted extensive atomistic and coarse-grained simulations to probe the temperature-dependent phase behaviors of ELF3, a disordered component of the evening complex in plant. The results aim to highlight the role of polyQ tracts in modulating temperature-responsive structural and condensation behavior. Despite considerable improvements in the revised manuscript, the level of evidence is considered incomplete, since several of the supplementary observables introduced to support the revised claim indicate that the variants studied are not statistically distinguishable within the reported replicate uncertainty.

Reviewed by eLife

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

1. Leonie Anton
2. Wenjing Cheng
3. Meseret T. Haile
4. Jerzy M. Dziekan
5. David W. Cobb
6. Xiyan Zhu
7. Leyan Han
8. Emerson Li
9. Anjali Nair
10. Carolyn L. Lee
11. Hanyu Wang
12. Hangjun Ke
13. Guoan Zhang
14. Emma H. Doud
15. Alan F. Cowman
16. Chi-Min Ho

Reviewed by Rapid Reviews Infectious Diseases

Collective directional memory controls the range of epithelial cell migration

1. Helena Canever
2. Hugo Lachuer
3. Quentin Delaunay
4. François Sipieter
5. Nicolas Audugé
6. Philippe P Girard
7. Nicolas Borghi

• Curated by eLife

  eLife Assessment

  The authors make the valuable observation that directional memory during epithelial cell migration is enhanced compared to single-cell migration. They attribute this effect to adherens junctions and vinculin dimerization. In the work, central measures should be defined more precisely, and the support for their claims about the roles of adherens junctions and vinculin dimerization in memory enhancement remains incomplete.

  [Editors' note: this paper was previously reviewed by another journal.]

Reviewed by eLife

When can AlphaFold predict the oligomeric states of proteins?

1. Yiechang Lin
2. Ciara Wallis
3. Ben Corry

Reviewed by PREreview

Universal length fluctuations of actin structures found in cells

1. Aldric Rosario
2. Shane G McInally
3. Predrag R Jelenkovic
4. Bruce L Goode
5. Jane Kondev

• Curated by eLife

  eLife Assessment

  This is a theoretical analysis that gives compelling evidence that length control of bundles of actin filaments undergoing assembly and disassembly emerges even in the absence of a length control mechanism at the individual filament level. Furthermore, the length distribution should exhibit a variance that grows quadratically with the average bundle length. The experimental data are compatible with these fundamental theoretical findings, but further investigations are necessary to make the work conclusive concerning the validity of the inferences for filamentous actin structures in cells.

Reviewed by eLife