Biophysics

Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1

1. Tsukasa Makino
2. Ryo Kanada
3. Teppei Mori
4. Ken-ichi Miyazono
5. Yuta Komori
6. Haruaki Yanagisawa
7. Shoji Takada
8. Masaru Tanokura
9. Masahide Kikkawa
10. Michio Tomishige

Reviewed by Review Commons

Extracellular matrix mediated stresses spatially bias myoblast fusion and myotube growth

1. Yoann Le Toquin
2. Sushil Dubey
3. Aleksandra Ardaševa
4. Lakshmi Balasubramaniam
5. Emilie Delaune
6. Valérie Morin
7. Amin Doostmohammadi
8. Christophe Marcelle
9. Benoît Ladoux

Reviewed by preLights

Probing the force-from-lipid mechanism with synthetic polymers

1. Miranda L Jacobs
2. Jan Steinkühler
3. Audra Lemley
4. Megan J Larmore
5. Taylor F Gunnels
6. Leo CT Ng
7. Stephanie M Cologna
8. Paul G DeCaen
9. Neha P Kamat

• Curated by eLife

  eLife Assessment

  Gating of mechanosensitive channels has been explained by the force-from-lipids model in which mechanical coupling of the channel protein to the plasma membrane transfers force from membrane tension to open the channel. In this important manuscript, the authors provide evidence for this mechanism in two different mechanically gated channels. The experiments were carried out in the same membranes, but the evidence is incomplete without a clear explanation of the relationship between measured mechanical parameters and membrane interfacial tension.

Reviewed by eLife

Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes

1. Emily N.P. Prowse
2. Abdullah R. Chaudhary
3. David Sharon
4. Adam G. Hendricks

Reviewed by preLights