1. FLIMPA: A Versatile Software for Fluorescence Lifetime Imaging Microscopy Phasor Analysis

    This article has 6 authors:
    1. Sofia Kapsiani
    2. Nino F. Läubli
    3. Edward N. Ward
    4. Mona Shehata
    5. Clemens F. Kaminski
    6. Gabriele S. Kaminski Schierle

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. Biophysical limits of ultrafast cellular motility

    This article has 2 authors:
    1. Ray Chang
    2. Manu Prakash

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  3. The interplay between biomolecular assembly and phase separation

    This article has 4 authors:
    1. Giacomo Bartolucci
    2. Ivar S Haugerud
    3. Thomas CT Michaels
    4. Christoph A Weber
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors present an important theoretical framework that describes the interplay between liquid-liquid phase separation and protein aggregation within a mean-field model. This work will be of high interest to the biophysics and molecular biology communities, as it will help understand and analyse assembly within biomolecular condensates in cells or in-vitro. Major strengths of this convincing work are the consideration of aggregates with various dimensionality and the possibility for protein gelation.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Phosphorylation regulated conformational diversity and topological dynamics of an intrinsically disordered nuclear receptor

    This article has 5 authors:
    1. Vasily Akulov
    2. Alba Jiménez Panizo
    3. Eva Estébanez-Perpiñá
    4. John van Noort
    5. Alireza Mashaghi

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  5. An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein

    This article has 3 authors:
    1. Sneha Menon
    2. Subinoy Adhikari
    3. Jagannath Mondal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study describes the application of machine learning and Markov state models to characterize the binding mechanism of alpha-Synuclein to the small molecule Fasudil. The results suggest that entropic expansion can explain such binding. However, the simulations and analyses in their present form are inadequate.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Direct and indirect salt effects on homotypic phase separation

    This article has 3 authors:
    1. Matt MacAinsh
    2. Souvik Dey
    3. Huan-Xiang Zhou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this potentially important study, the authors conducted atomistic simulations to probe the salt-dependent phase separation of the low-complexity domain of hnRN-PA1 (A1-LCD). The authors have identified both direct and indirect mechanisms of salt modulation, provided explanations for four distinct classes of salt dependence, and proposed a model for predicting protein properties from amino acid composition. There is a range of opinions regarding the strength of evidence, with some considering the evidence as incomplete due to the limitations in the length and statistical errors of the computationally intense atomistic MD simulations.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

    This article has 7 authors:
    1. Augustus J Lowry
    2. Pengfei Liang
    3. Mo Song
    4. Yuichun Wan
    5. Zhen-Ming Pei
    6. Huanghe Yang
    7. Yang Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study advances our understanding of the mechanisms controlling lipid flux and ion permeation in the TMEM16 and OSCA/TMEM63 family channels. The study provides compelling new evidence indicating that side chains along the TM4/6 interface play a key role in gating lipid and ion fluxes in these channels. The authors suggest that the transmembrane channel/scramblase family proteins may have originally functioned as scramblases but lost this capacity over evolution.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  8. HIV integrase compacts viral DNA into biphasic condensates

    This article has 14 authors:
    1. Pauline J Kolbeck
    2. Marjolein de Jager
    3. Margherita Gallano
    4. Tine Brouns
    5. Ben Bekaert
    6. Wout Frederickx
    7. Sebastian F Konrad
    8. Siska Van Belle
    9. Frauke Christ
    10. Steven De Feyter
    11. Zeger Debyser
    12. Laura Filion
    13. Jan Lipfert
    14. Willem Vanderlinden
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript by Kolbeck and co-workers is an important contribution to understanding the physical mechanism that controls a key step in the retroviral infectious cycle. The authors employ a wide range of experimental techniques, complemented with Montecarlo simulations, that result in convincing evidence of compaction of HIV DNA by the viral integrase. This manuscript would benefit from in-depth discussion and analysis of the biophysical implications of the results.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Protein-Induced Membrane Strain Drives Supercomplex Formation

    This article has 4 authors:
    1. Maximilian C Pöverlein
    2. Alexander Jussupow
    3. Hyunho Kim
    4. Ville RI Kaila
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this potentially important study, the authors conducted extensive atomistic and coarse-grained simulations as well as a lattice Monte Carlo analysis to probe the driving force and functional impact of supercomplex formation in the inner mitochondrial membrane. The study highlighted the importance of membrane mechanics to the supercomplex formation and revealed differences in structural and dynamical features of the protein components upon complex formation. In its current form, the analysis is considered incomplete, especially concerning the contributions of membrane mechanics and allosteric coupling of key regions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity

    This article has 9 authors:
    1. Keisuke Motone
    2. Daphne Kontogiorgos-Heintz
    3. Jasmine Wee
    4. Kyoko Kurihara
    5. Sangbeom Yang
    6. Gwendolin Roote
    7. Yishu Fang
    8. Nicolas Cardozo
    9. Jeff Nivala

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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