Biophysics

  1. Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes

    1. Dario D’Asaro
    2. Jean-Michel Arbona
    3. Vinciane Piveteau
    4. Aurèle Piazza
    5. Cédric Vaillant
    6. Daniel Jost

    Reviewed by Review Commons

    5 evaluationsAppears in 1 listLatest version Latest activity

  3. Emergence of specific binding and catalysis from a designed generalist binding protein

    1. Yuda Chen
    2. Sagar Bhattacharya
    3. Lena Bergmann
    4. Galen J. Correy
    5. Sophia K. Tan
    6. Kaipeng Hou
    7. Justin T. Biel
    8. Lei Lu
    9. Ian Bakanas
    10. Jason E. Gestwicki
    11. Alexander N. Volkov
    12. Ivan V. Korendovych
    13. Nicholas F. Polizzi
    14. James S. Fraser
    15. William F. DeGrado

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  6. AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network

    1. Alisia Fadini
    2. Minhuan Li
    3. Airlie J. McCoy
    4. Suresh Banjara
    5. Hiroki Okumura
    6. Eve Napier
    7. Pietro Fontana
    8. Amir R. Khan
    9. Luca Jovine
    10. Thomas C. Terwilliger
    11. Randy J. Read
    12. Doeke R. Hekstra
    13. Mohammed AlQuraishi

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

    1. Wei Dong
    2. Guihu Wang
    3. Senyang Li
    4. Yichao Chai
    5. Qian Wang
    6. Yucheng Li
    7. Qiaoman Fei
    8. Yujin Zong
    9. Jing Geng
    10. Pengfei Liu
    11. Zongfang Li

    • Curated by eLife

      eLife Assessment

      This valuable study presents an innovative noninvasive immunotherapeutic strategy for hepatocellular carcinoma by combining ultrasound stimulation with calcium-loaded nanodroplets to activate splenic immune responses. The authors provide solid preclinical data, including single-cell transcriptomic analyses and evidence of tumor growth suppression, supported by a creative and well-executed methodology. Further validation of the calcium signaling mechanisms and assessment of long-term safety will strengthen the translational potential of this approach. The work will be of broad interest to researchers in oncology, immunotherapy, and biomedical engineering.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit

    1. Kunwoong Park
    2. Youngki Yoo
    3. Hyunbum Jeon
    4. Kiju Choi
    5. Hanseong Kim
    6. Eunju Kwon
    7. Hyun-Ho Lim
    8. Dong Young Kim
    9. Kyoung Tai No

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity
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