Biophysics

AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network

1. Alisia Fadini
2. Minhuan Li
3. Airlie J. McCoy
4. Suresh Banjara
5. Hiroki Okumura
6. Eve Napier
7. Pietro Fontana
8. Amir R. Khan
9. Luca Jovine
10. Thomas C. Terwilliger
11. Randy J. Read
12. Doeke R. Hekstra
13. Mohammed AlQuraishi

Reviewed by PREreview

Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

1. Wei Dong
2. Guihu Wang
3. Senyang Li
4. Yichao Chai
5. Qian Wang
6. Yucheng Li
7. Qiaoman Fei
8. Yujin Zong
9. Jing Geng
10. Pengfei Liu
11. Zongfang Li

• Curated by eLife

  eLife Assessment

  This valuable study presents an innovative noninvasive immunotherapeutic strategy for hepatocellular carcinoma by combining ultrasound stimulation with calcium-loaded nanodroplets to activate splenic immune responses. The authors provide solid preclinical data, including single-cell transcriptomic analyses and evidence of tumor growth suppression, supported by a creative and well-executed methodology. Further validation of the calcium signaling mechanisms and assessment of long-term safety will strengthen the translational potential of this approach. The work will be of broad interest to researchers in oncology, immunotherapy, and biomedical engineering.

Reviewed by eLife

High-resolution cryo-EM structures of small protein–ligand complexes near the theoretical size limit

1. Kunwoong Park
2. Youngki Yoo
3. Hyunbum Jeon
4. Kiju Choi
5. Hanseong Kim
6. Eunju Kwon
7. Hyun-Ho Lim
8. Dong Young Kim
9. Kyoung Tai No

Reviewed by PREreview

Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities

1. Ananya Benegal
2. Yuanyuan He
3. Katilyn Ho
4. Giselle Groff
5. Zijian Guo
6. Michael D. Vahey

Reviewed by Review Commons