Biophysics

Swirling motion of breast cancer cells radially aligns collagen fibers to enable collective invasion

1. Aashrith Saraswathibhatla
2. Md Foysal Rabbi
3. Sushama Varma
4. Vasudha Srivastava
5. Olga Ilina
6. Naomi Hassan Kahtan Alyafei
7. Louis Hodgson
8. Zev Gartner
9. Peter Friedl
10. Robert West
11. Taeyoon Kim
12. Ovijit Chaudhuri

Reviewed by preLights

Reconstitution of actomyosin networks in cell-sized liposomes reveals distinct mechanical roles of cytoskeletal organization in membrane shape remodeling

1. Makito Miyazaki
2. Fahmida Sultana Laboni
3. Taeyoon Kim

Reviewed by Arcadia Science

Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy

1. Maciej A Kerlin
2. Ilham Aboulfath-Ladid
3. Julia Roensch
4. Chloé Jaubert
5. Aude Battistella
6. Kyra JE Borgman
7. Antoine Coulon

• Curated by eLife

  eLife Assessment

  This important study combines an innovative experimental approach with mathematical modeling to demonstrate that genes separated by strong topological boundaries can exhibit coordinated transcriptional bursting, providing new insights into how regulatory information is transmitted across the genome. The evidence is solid within the studied locus, but the interpretation and generality of the findings would be strengthened by additional validation using simulated data and broader application beyond a single genomic region. This work will be of interest to cell biologists and biophysicists working on transcription and chromatin.

Reviewed by eLife