Bioengineering

  1. Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane

    1. Einollah Sarikhani
    2. Vrund Patel
    3. Zhi Li
    4. Dhivya Pushpa Meganathan
    5. Keivan Rahmani
    6. Leah Sadr
    7. Ryan Hosseini
    8. Diether Visda
    9. Shivani Shukla
    10. Hamed Naghsh‐Nilchi
    11. Adarsh Balaji
    12. Gillian McMahon
    13. Shaoming Chen
    14. Johannes Schöneberg
    15. Colleen A. McHugh
    16. Lingyan Shi
    17. Zeinab Jahed

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Two mechanisms of photoenergy regulation revealed by kinetic behaviors of chlorophyll fluorescence during light adaptation

    1. Junqing Chen
    2. Lijiang Fu
    3. Ya Guo
    4. Jinglu Tan

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  3. A 3D-printed handheld device for quick citrus tissue lysis and nucleic acid extraction

    1. Chia-Wei Liu
    2. Brent Kalish
    3. Sohrab Bodaghi
    4. Georgios Vidalakis
    5. Hideaki Tsutsui

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

    1. Qingqing Feng
    2. Keman Cheng
    3. Lizhuo Zhang
    4. Xiaoyu Gao
    5. Jie Liang
    6. Guangna Liu
    7. Nana Ma
    8. Chen Xu
    9. Ming Tang
    10. Liting Chen
    11. Xinwei Wang
    12. Xuehui Ma
    13. Jiajia Zou
    14. Quanwei Shi
    15. Pei Du
    16. Qihui Wang
    17. Guangjun Nie
    18. Xiao Zhao

    Reviewed by Rapid Reviews Infectious Diseases

    2 evaluationsAppears in 1 listLatest version Latest activity

  5. Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts

    1. Tino Stauber
    2. Greta Moschini
    3. Amro A Hussien
    4. Patrick Klaus Jaeger
    5. Katrien De Bock
    6. Jess G Snedeker

    • Curated by eLife

      eLife assessment

      This important study defines signaling mechanisms in tendinopathy development, which is significant as there is a clear need to identify therapeutic targets to prevent or reverse tendon pathology. The evidence supporting the conclusions are compelling combining an existing human tendinopathy transcriptomics dataset with ex-vivo assembloid model, and an in vivo injury model using genetic reporter mice. This work will be of interest to developmental and stem cell biologists.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  6. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

    1. Megan M Sperry
    2. Berenice Charrez
    3. Haleh Fotowat
    4. Erica Gardner
    5. Kanoelani Pilobello
    6. Zohreh Izadifar
    7. Tiffany Lin
    8. Abigail Kuelker
    9. Sahith Kaki
    10. Michael Lewandowski
    11. Shanda Lightbown
    12. Ramses Martinez
    13. Susan Marquez
    14. Joel Moore
    15. Maria Plaza-Oliver
    16. Adama M Sesay
    17. Kostyantyn Shcherbina
    18. Katherine Sheehan
    19. Takako Takeda
    20. Daniela Del Campo
    21. Kristina Andrijauskaite
    22. Exal Cisneros
    23. Riley Lopez
    24. Isabella Cano
    25. Zachary Maxwell
    26. Israel Jessop
    27. Rafa Veraza
    28. Leon Bunegin
    29. Thomas J Percival
    30. Jaclyn Yracheta
    31. Jorge J Pena
    32. Diandra M Wood
    33. Zachary T Homas
    34. Cody J Hinshaw
    35. Jennifer Cox-Hinshaw
    36. Olivia G Parry
    37. Justin J Sleeter
    38. Erik K Weitzel
    39. Michael Levin
    40. Michael Super
    41. Richard Novak
    42. Donald E Ingber

    • Curated by eLife

      eLife assessment

      Pharmacological induction of physiological slowing combined with organ perfusion systems could provide a novel therapeutic strategy for tissue and organ preservation. Using a Xenopus model, the authors provide important findings on a use of drug to slow down metabolism for the purpose of organ preservation. The authors provide compelling evidence that SNC80 can rapidly and reversibly slow biochemical and metabolic activities while preserving cell and tissue viability. This approach may be beneficial for transplantation, trauma management, and improving organ survival in remote and low-resource settings

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  7. Development of a highly active engineered PETase enzyme for polyester degradation

    1. Shapla Bhattacharya
    2. Rossella Castagna
    3. Hajar Estiri
    4. Toms Upmanis
    5. Andrea Ricci
    6. Alfonso Gautieri
    7. Emilio Parisini

    Reviewed by Arcadia Science

    6 evaluationsAppears in 1 listLatest version Latest activity

  8. Programming Aliphatic Polyester Degradation by Engineered Bacterial Spores

    1. Ziyu Cui
    2. Masamu Kawada
    3. Yue Hui
    4. Seunghyun Sim

    Reviewed by Arcadia Science

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. Rapid protein evolution by few-shot learning with a protein language model

    1. Kaiyi Jiang
    2. Zhaoqing Yan
    3. Matteo Di Bernardo
    4. Samantha R. Sgrizzi
    5. Lukas Villiger
    6. Alisan Kayabolen
    7. Byungji Kim
    8. Josephine K. Carscadden
    9. Masahiro Hiraizumi
    10. Hiroshi Nishimasu
    11. Jonathan S. Gootenberg
    12. Omar O. Abudayyeh

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells

    1. Srishti U. Sahu
    2. Madalena Castro
    3. Joseph J. Muldoon
    4. Kunica Asija
    5. Stacia K. Wyman
    6. Netravathi Krishnappa
    7. Lorena de Oñate
    8. Justin Eyquem
    9. David N. Nguyen
    10. Ross C. Wilson

    Reviewed by Arcadia Science

    11 evaluationsAppears in 1 listLatest version Latest activity
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