Bioengineering

Mosaic receptor-binding domain nanoparticles induce protective immunity against SARS-CoV-2 challenges

1. Dan Bi Lee
2. Hyojin Kim
3. Ju Hwan Jeong
4. Ui soon Jang
5. You Yeon Chang
6. Seokbeom Roh
7. Hyunbum Jeon
8. Eun Jeong Kim
9. Su Yeon Han
10. Jin Young Maeng
11. Stefan Magez
12. Magdalena Radwanska
13. Ji Young Mun
14. Hyun Sik Jun
15. Gyudo Lee
16. Min-Suk Song
17. Hye-Ra Lee
18. Mi Sook Chung
19. Yun Hee Baek
20. Kyung Hyun Kim

Reviewed by ScreenIT

Biomechanical Dependence of SARS-CoV-2 Infections

1. Alexandra Paul
2. Sachin Kumar
3. Tamer S. Kaoud
4. Madison R. Pickett
5. Amanda L. Bohanon
6. Janet Zoldan
7. Kevin N. Dalby
8. Sapun H. Parekh

Reviewed by ScreenIT

Engineering defensin α‐helix to produce high‐affinity SARS‐CoV ‐2 spike protein binding ligands

1. Leonardo Antônio Fernandes
2. Anderson Albino Gomes
3. Beatriz Gomes Guimarães
4. Maria de Lourdes Borba Magalhães
5. Partha Ray
6. Gustavo Felippe da Silva

Reviewed by ScreenIT

Preclinical Establishment of a Divalent Vaccine against SARS-CoV-2

1. Zsofia Hevesi
2. Daniela Anna Gerges
3. Sebastian Kapps
4. Raimundo Freire
5. Sophie Schmidt
6. Daniela D. Pollak
7. Klaus Schmetterer
8. Tobias Frey
9. Rita Lang
10. Wolfgang Winnicki
11. Alice Schmidt
12. Tibor Harkany
13. Ludwig Wagner

Reviewed by ScreenIT

Human cardiac organoids to model COVID‐19 cytokine storm induced cardiac injuries

1. Dimitrios C. Arhontoulis
2. Charles M. Kerr
3. Dylan Richards
4. Kelsey Tjen
5. Nathaniel Hyams
6. Jefferey A. Jones
7. Kristine Deleon‐Pennell
8. Donald Menick
9. Hanna Bräuninger
10. Diana Lindner
11. Dirk Westermann
12. Ying Mei

Reviewed by ScreenIT

Genetically engineered insects with sex-selection and genetic incompatibility enable population suppression

1. Ambuj Upadhyay
2. Nathan R Feltman
3. Adam Sychla
4. Anna Janzen
5. Siba R Das
6. Maciej Maselko
7. Michael Smanski

• Curated by eLife

  Evaluation Summary:

  This paper is of interest to entomologists caring for genetic pest control or molecular biologists following synthetic biology. The authors describe a fruit fly strain that combines constructs that establish both repressible female-lethality and genetic incompatibility based on CRISPR transactivation. They show that this strain has high penetrance for these two traits and that it can suppress wild-type flies when released into cycling cage populations. The paper is thus a neat technology demonstration for a genetic control strategy possibly applicable to other insects including pests or disease vectors.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Nanoformulated Remdesivir with Extremely Low Content of Poly(2‐oxazoline)‐Based Stabilizer for Aerosol Treatment of COVID‐19

1. Jacob D. Ramsey
2. Ian E. Stewart
3. Emily A. Madden
4. Chaemin Lim
5. Duhyeong Hwang
6. Mark T. Heise
7. Anthony J. Hickey
8. Alexander V. Kabanov

Reviewed by ScreenIT

Targeting SARS-CoV-2 infection through CAR-T like bispecific T cell engagers incorporating ACE2

1. Mikail Dogan
2. Lina Kozhaya
3. Lindsey Placek
4. Fatih Karabacak
5. Mesut Yigit
6. Derya Unutmaz

Reviewed by ScreenIT

Immunokinetic Model for COVID-19 Patients

1. Y. Fadaei
2. F. A. Rihan
3. C Rajivganthi

Reviewed by ScreenIT

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

1. Fangzhu Zhao
2. Celina Keating
3. Gabriel Ozorowski
4. Namir Shaabani
5. Irene M. Francino-Urdaniz
6. Shawn Barman
7. Oliver Limbo
8. Alison Burns
9. Panpan Zhou
10. Michael J. Ricciardi
11. Jordan Woehl
12. Quoc Tran
13. Hannah L. Turner
14. Linghang Peng
15. Deli Huang
16. David Nemazee
17. Raiees Andrabi
18. Devin Sok
19. John R. Teijaro
20. Timothy A. Whitehead
21. Andrew B. Ward
22. Dennis R. Burton
23. Joseph G. Jardine

Reviewed by ScreenIT