Biochemistry

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

1. Wenning Lan
2. Xiaolian Xiao
3. Xiaojing Zhang
4. Jingjing Nian
5. Ziran Wang
6. Yajiao Wu
7. Dongcheng Zhang
8. Junkun Chen
9. Wenqiang Bao
10. Chutao Li
11. An Zhu
12. Yun Zhang
13. Fangrong Zhang

Reviewed by PREreview

idh-1 neomorphic mutation confers sensitivity to vitamin B12 via increased dependency on one-carbon metabolism in Caenorhabditis elegans

1. Olga Ponomarova
2. Alyxandra N. Starbard
3. Alexandra Belfi
4. Amanda V. Anderson
5. Meera V. Sundaram
6. Albertha J.M. Walhout

Reviewed by Review Commons

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

1. Christopher Chin Sang
2. Gaelen Moore
3. Maria Tereshchenko
4. Michael L. Nosella
5. Hongshan Zhang
6. T. Reid Alderson
7. Morgan Dasovich
8. Anthony Leung
9. Ilya J. Finkelstein
10. Julie D. Forman-Kay
11. Hyun O. Lee

Reviewed by Review Commons

Toxin-based screening of C-terminal tags in Escherichia coli reveals the exceptional potency of ssrA-like degrons

1. Patrick C. Beardslee
2. Karl R. Schmitz

• Curated by eLife

  eLife assessment

  This important study employs an innovative genetic selection-based approach to identify short peptide sequences that target bacterial proteins for degradation. Using random mutagenesis they identified 5 amino acid long "degrons" that target the toxin VapC for degradation permitting survival. They provide compelling data that degrons ending in Ala-Ala are selectively recognized by the ClpXP protease and identify the sequence FKLVA as a particularly significant target. As a whole, there is enthusiasm about the author's findings, although there are also some improvements that could be made to increase the clarity and impact, mostly in the form of revisions to the text.

Reviewed by eLife