1. CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

    This article has 5 authors:
    1. LuYan Cao
    2. Shaina Huang
    3. Angika Basant
    4. Miroslav Mladenov
    5. Michael Way

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

    This article has 6 authors:
    1. Fujun Zhou
    2. Julie M Bocetti
    3. Meizhen Hou
    4. Daoming Qin
    5. Alan G Hinnebusch
    6. Jon R Lorsch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important paper as it is the first to use a reconstituted translation system to study competition among mRNAs for the initiation machinery. Understanding the principles of the biochemistry of mRNA competition for initiation factors cannot be achieved without such a system. The authors provide compelling evidence that Ded1 is required for efficient initiation of highly structured mRNAs. The findings are significant and validate the in vitro reconstituted system by recapitulating the effects of in-vivo perturbations of translation initiation by Ded1 mutants.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Viral proteins activate PARIS-mediated tRNA degradation and viral tRNAs rescue infection

    This article has 26 authors:
    1. Nathaniel Burman
    2. Svetlana Belukhina
    3. Florence Depardieu
    4. Royce A. Wilkinson
    5. Mikhail Skutel
    6. Andrew Santiago-Frangos
    7. Ava B. Graham
    8. Alexei Livenskyi
    9. Anna Chechenina
    10. Natalia Morozova
    11. Trevor Zahl
    12. William S. Henriques
    13. Murat Buyukyoruk
    14. Christophe Rouillon
    15. Lena Shyrokova
    16. Tatsuaki Kurata
    17. Vasili Hauryliuk
    18. Konstantin Severinov
    19. Justine Groseille
    20. Agnès Thierry
    21. Romain Koszul
    22. Florian Tesson
    23. Aude Bernheim
    24. David Bikard
    25. Blake Wiedenheft
    26. Artem Isaev

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin

    This article has 3 authors:
    1. Ao Liu
    2. Anna L. Hatch
    3. Henry N. Higgs

    Reviewed by Review Commons

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Fascin-induced bundling protects actin filaments from disassembly by cofilin

    This article has 7 authors:
    1. Jahnavi Chikireddy
    2. Léana Lengagne
    3. Rémi Le Borgne
    4. Catherine Durieu
    5. Hugo Wioland
    6. Guillaume Romet-Lemonne
    7. Antoine Jégou

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

    This article has 10 authors:
    1. Valentin Bohl
    2. Nele Merret Hollmann
    3. Tobias Melzer
    4. Panagiotis Katikaridis
    5. Lena Meins
    6. Bernd Simon
    7. Dirk Flemming
    8. Irmgard Sinning
    9. Janosch Hennig
    10. Axel Mogk
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important manuscript details the characterization of ClpL from L. monocytogenes as an effective and autonomous AAA+ disaggregase that provides enhanced heat resistance to this food-borne pathogen. Supported by compelling evidence, the authors demonstrate that ClpL has DnaK-independent disaggregase activity towards a variety of aggregated model substrates, which is more potent than that observed with the endogenous canonical DnaK/ClpB bi-chaperone system. The work will be of broad interest to microbiologists and biochemists.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. X-ray structure and enzymatic study of a bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

    This article has 10 authors:
    1. Isabelle Petit-Hartlein
    2. Annelise Vermot
    3. Michel Thepaut
    4. Anne-Sophie Humm
    5. Florine Dupeux
    6. Jerome Dupuy
    7. Vincent Chaptal
    8. Jose Antonio Marquez
    9. Susan ME Smith
    10. Franck Fieschi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this manuscript, the authors investigate the properties of prokaryotic NADPH oxidases (NOX) and discuss the implications for NOX regulation and function. The structure of the S. pneumoniae Nox protein is an important step forward in our understanding of procaryotic NOX enzymes and the characterization and interpretation are convincing. The results will be of interest to structural biologists as well as biochemists focusing on enzymatic functions.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. The C-terminus of CFAP410 forms a tetrameric helical bundle that is essential for its localization to the basal body

    This article has 10 authors:
    1. Alexander Stadler
    2. Laryssa V. De Liz
    3. Heloisa B. Gabriel
    4. Santiago Alonso-Gil
    5. Robbie Crickley
    6. Katharina Korbula
    7. Bojan Žagrović
    8. Sue Vaughan
    9. Jack D. Sunter
    10. Gang Dong

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    This article has 4 authors:
    1. Karolina Honzejkova
    2. Dalibor Kosek
    3. Veronika Obsilova
    4. Tomas Obsil
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important manuscript reports the cryo-EM structure of the ASK1 protein, which is a critical regulator of the MAPKs, JNKs, and p38 MAPKs in diverse cellular stress responses. The evidence of ASK1 interaction with TRX1 is compelling and will eventually allow the discovery of small molecule inhibitors of ASK1 activity.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli

    This article has 4 authors:
    1. Sebastian Jojoa-Cruz
    2. Adrienne E Dubin
    3. Wen-Hsin Lee
    4. Andrew B Ward
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript seeks to dissect the molecular underpinnings of poke and stretch activation in OSCA channels. While the structural and functional experiments are well done, and the authors present some important data, the reviewers identified weaknesses in experimental design and interpretation that render the data incomplete in supporting some of the main conclusions of the paper. Nevertheless, this work will be of interest to those working in the fields of mechanosensation, sensory biology, and ion channels.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
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