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  1. Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

    This article has 2 authors:
    1. Eric B Zheng
    2. Li Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      By integrating in silico predictions and mass-spectrometry, this manuscript tackles the problem of annotating the currently nameless stretches of genomic sequence that actually code for proteins. The hundreds of protein coding fruit fly genes described here offer new inroads for studying some of the very youngest functional elements in genomes, particularly those that have recently emerged from non-coding DNA sequences. To clarify the biological significance of the present study, the authors should both highlight the genes mostly like to encode functional products and conduct a comparison to published datasets that used different methods to identify such genes in fruit flies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by Arcadia Science, eLife

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