Evaluated articles

Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction

1. James Boocock
2. Noah Alexander
3. Leslie Alamo Tapia
4. Laura Walter-McNeill
5. Shivani Prashant Patel
6. Chetan Munugala
7. Joshua S Bloom
8. Leonid Kruglyak

• Curated by eLife

  eLife assessment

  This manuscript describes the mapping of natural DNA sequence variants that affect gene expression and its noise, as well as cell cycle timing, using as input single-cell RNA-sequencing of progeny from crosses between wild yeast strains. The method represents an important advance in the study of natural genetic variation. The findings, especially given the follow-up validation of the phenotypic impact of a mapped locus of major effect, provide convincing support for the rigor and utility of the method.

Reviewed by eLife, Arcadia Science

RamanSPy : An open-source Python package for integrative Raman spectroscopy data analysis

1. Dimitar Georgiev
2. Simon Vilms Pedersen
3. Ruoxiao Xie
4. Álvaro Fernández-Galiana
5. Molly M. Stevens
6. Mauricio Barahona

Reviewed by Arcadia Science

Technical upgrade of an open-source liquid handler to support bacterial colony screening

1. Irene del Olmo
2. Pablo Yubero
3. Álvaro Gómez-Luengo
4. Juan Nogales
5. David R. Espeso

Reviewed by Arcadia Science

Functional annotation hypothetical proteins: a world to be explored in drug development in Trypanosomatids

1. Raissa Santos de Lima
2. Ana Carolina Silva Bulla
3. Manuela Leal da Silva

Reviewed by Arcadia Science

Nanos2+ cells give rise to germline and somatic lineages in the sea anemone Nematostella vectensis

1. Andreas Denner
2. Julia Steger
3. Alexander Ries
4. Elizaveta Morozova-Link
5. Josefine Ritter
6. Franziska Haas
7. Alison G. Cole
8. Ulrich Technau

Reviewed by Arcadia Science

Beyond blast: enabling microbiologists to better extract literature, taxonomic distributions and gene neighbourhood information for protein families

1. Colbie J. Reed
2. Rémi Denise
3. Jacob Hourihan
4. Jill Babor
5. Marshall Jaroch
6. Maria Martinelli
7. Geoffrey Hutinet
8. Valérie de Crécy-Lagard

Reviewed by Arcadia Science

Novel Association of Lyme disease, Age, and Atopic Dermatitis

1. Brandon T. Lee
2. Sarah D. Galloway
3. Qingying Feng
4. Satu Strausz
5. Maia Shoham
6. Paige Hansen
7. Laughing Bear Torrez Dulgeroff
8. Grace Blacker
9. Ying Y. Yiu
10. Paul Mansfield
11. FinnGen
12. Atif Saleem
13. Eric Gars
14. Erin C. Sanders
15. Irving L. Weissman
16. Hanna M. Ollila
17. Michal Caspi Tal

Reviewed by Arcadia Science

Evolutionary trends of alternative splicing

1. Rebeca de la Fuente
2. Wladimiro Díaz-Villanueva
3. Vicente Arnau
4. Andrés Moya

• Curated by eLife

  eLife assessment

  The authors examined whether the frequency of alternative splicing across entire genomes correlates with measures of complexities across prokaryotes and eukaryotes. Although the question is very interesting and important for our general understanding of the evolution of life forms, the work is inadequate: the methods, data, and analyses do not support the primary claims. The measure of alternative splicing frequency used by the authors is problematic; the method is inappropriate; the observed correlations may also be explained by known population genetics principles; and parts of the manuscript are difficult to understand.

Reviewed by Arcadia Science, eLife

ADPKD-Causing Missense Variants in Polycystin-1 Disrupt Cell Surface Localization or Polycystin Channel Function

1. Kotdaji Ha
2. Gabriel B. Loeb
3. Meyeon Park
4. Mohona Gupta
5. Yukako Akiyama
6. Jillian Argiris
7. Aide Pinedo
8. Christine Haewon Park
9. Nadav Brandes
10. F. Ritu
11. Chun Jimmie Ye
12. Jeremy F. Reiter
13. Markus Delling

Reviewed by Arcadia Science

Contextual and Combinatorial Structure in Sperm Whale Vocalisations

1. Pratyusha Sharma
2. Shane Gero
3. Roger Payne
4. David F. Gruber
5. Daniela Rus
6. Antonio Torralba
7. Jacob Andreas

Reviewed by Arcadia Science

A joint embedding of protein sequence and structure enables robust variant effect predictions

1. Lasse M. Blaabjerg
2. Nicolas Jonsson
3. Wouter Boomsma
4. Amelie Stein
5. Kresten Lindorff-Larsen

Reviewed by Arcadia Science

Engram reactivation mimics cellular signatures of fear

1. Rebecca L. Suthard
2. Ryan A. Senne
3. Michelle D. Buzharsky
4. Anh H. Diep
5. Angela Y. Pyo
6. Steve Ramirez

Reviewed by Arcadia Science

FAIR Header Reference genome: a TRUSTworthy standard

1. Adam Wright
2. Mark D Wilkinson
3. Christopher Mungall
4. Scott Cain
5. Stephen Richards
6. Paul Sternberg
7. Ellen Provin
8. Jonathan L Jacobs
9. Scott Geib
10. Daniela Raciti
11. Karen Yook
12. Lincoln Stein
13. David C Molik

Reviewed by Arcadia Science

Predicting phage-bacteria interactions at the strain level from genomes

1. Baptiste Gaborieau
2. Hugo Vaysset
3. Florian Tesson
4. Inès Charachon
5. Nicolas Dib
6. Juliette Bernier
7. Tanguy Dequidt
8. Héloïse Georjon
9. Olivier Clermont
10. Pascal Hersen
11. Laurent Debarbieux
12. Jean-Damien Ricard
13. Erick Denamur
14. Aude Bernheim

Reviewed by Arcadia Science

Chromatin profiling data indicate regulatory mechanisms for differentiation during development in the acoel Hofstenia miamia

1. Paul Bump
2. Kaitlyn Loubet-Senear
3. Sarah Arnold
4. Mansi Srivastava

Reviewed by Arcadia Science

Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen

1. Allen G. Sanderlin
2. Hannah K. Margolis
3. Abigail F. Meyer
4. Rebecca L. Lamason

Reviewed by Arcadia Science

The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations

1. Marcus Harrell
2. Ziyi Liu
3. Bethany F Campbell
4. Olivia Chinsen
5. Tian Hong
6. Maitreyi Das

Reviewed by Arcadia Science

Bidirectional chemogenetic modulation of claustral activity causes altered cortical dynamics

1. Ryan Zahacy
2. Yonglie Ma
3. Ian R. Winship
4. Jesse Jackson
5. Allen W. Chan

Reviewed by Arcadia Science

Characterizing Human KIF1Bß Motor Activity by Single-Molecule Motility Assays and Caenorhabtidis elegans Genetics

1. Rei Iguchi
2. Tomoki Kita
3. Taisei Watanabe
4. Kyoko Chiba
5. Shinsuke Niwa

Reviewed by Arcadia Science

Learning orientation-invariant representations enables accurate and robust morphologic profiling of cells and organelles

1. James Burgess
2. Jeffrey J. Nirschl
3. Maria-Clara Zanellati
4. Sarah Cohen
5. Serena Yeung

Reviewed by Arcadia Science