Evaluated articles

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types

1. Ana Miar
2. Esther Arnaiz
3. Esther Bridges
4. Shaunna Beedie
5. Adam P. Cribbs
6. Damien J. Downes
7. Robert A. Beagrie
8. Jan Rehwinkel
9. Adrian L. Harris

Reviewed by preLights

Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects

1. Snehal N. Chaudhari
2. David A. Harris
3. Hassan Aliakbarian
4. Matthew T. Henke
5. Renuka Subramaniam
6. Ashley H. Vernon
7. Ali Tavakkoli
8. Eric G. Sheu
9. A. Sloan Devlin

Reviewed by preLights

3D quantification of zebrafish cerebrovascular architecture by automated image analysis of light sheet fluorescence microscopy datasets

1. E. C. Kugler
2. J. Frost
3. V. Silva
4. K. Plant
5. K. Chhabria
6. T. J.A. Chico
7. P. A. Armitage

Reviewed by preLights

Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons

1. Abeer Dagra
2. Douglas R. Miller
3. Fatemeh Shaerzadeh
4. Min Lin
5. Adithya Gopinath
6. Sharonda Harris
7. Zachary A. Sorrentino
8. Sophia Velasco
9. Adetola R Alonge
10. Janelle Azar
11. Joe J Lebowitz
12. Brittany Ulm
13. Anthea-Mengfei Bu
14. Carissa A. Hansen
15. Nikhil Urs
16. Benoit I. Giasson
17. Habibeh Khoshbouei

Reviewed by preLights

Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning

1. Philip B. Abitua
2. Laura M. Stump
3. Deniz C. Aksel
4. Alexander F. Schier

Reviewed by preLights

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

1. Wei Wu
2. Sarah E. Hill
3. William J. Nathan
4. Jacob Paiano
5. Kenta Shinoda
6. Jennifer Colon-Mercado
7. Elsa Callen
8. Raffaella de Pace
9. Dongpeng Wang
10. Han-Yu Shih
11. Steve Coon
12. Maia Parsadanian
13. Hana Hanzlikova
14. Peter J. McHugh
15. Andres Canela
16. Keith W. Caldecott
17. Michael E. Ward
18. André Nussenzweig

Reviewed by preLights

Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish

1. Kunal Chopra
2. Milda Folkmanaitė
3. Liam Stockdale
4. Vishali Shathish
5. Shoko Ishibashi
6. Rachel Bergin
7. Jorge Amich
8. Enrique Amaya

Reviewed by preLights

Sexual conflict promotes species coexistence through negative frequency dependence

1. Miguel Gomez-Llano
2. Sofie Nilén
3. Iain Moodie
4. Erik I. Svensson

Reviewed by preLights

An open-access volume electron microscopy atlas of whole cells and tissues

1. C. Shan Xu
2. Song Pang
3. Gleb Shtengel
4. Andreas Müller
5. Alex T. Ritter
6. Huxley K. Hoffman
7. Shin-ya Takemura
8. Zhiyuan Lu
9. H. Amalia Pasolli
10. Nirmala Iyer
11. Jeeyun Chung
12. Davis Bennett
13. Aubrey V. Weigel
14. Melanie Freeman
15. Schuyler B. van Engelenburg
16. Tobias C. Walther
17. Robert V. Farese
18. Jennifer Lippincott-Schwartz
19. Ira Mellman
20. Michele Solimena
21. Harald F. Hess

Reviewed by preLights

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

1. Sandra Segura-Bayona
2. Marina Villamor-Payà
3. Camille Stephan-Otto Attolini
4. Lars M. Koenig
5. Maria Sanchiz-Calvo
6. Simon J. Boulton
7. Travis H. Stracker

Reviewed by preLights

Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease

1. Rebecca Panitch
2. Junming Hu
3. Jaeyoon Chung
4. Congcong Zhu
5. Gaoyuan Meng
6. Weiming Xia
7. David A. Bennett
8. Kathryn L. Lunetta
9. Tsuneya Ikezu
10. Rhoda Au
11. Thor D. Stein
12. Lindsay A. Farrer
13. Gyungah R. Jun

Reviewed by preLights

Rapid microbial interaction network inference in microfluidic droplets

1. Ryan H. Hsu
2. Ryan L. Clark
3. Jin Wen Tan
4. Philip A. Romero
5. Ophelia S. Venturelli

Reviewed by preLights

Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract

1. Sabrina I. Green
2. Carmen Gu Liu
3. Xue Yu
4. Shelley Gibson
5. Wilhem Salmen
6. Anubama Rajan
7. Hannah E. Carter
8. Justin R. Clark
9. Xuezheng Song
10. Robert F. Ramig
11. Barbara W. Trautner
12. Heidi B. Kaplan
13. Anthony W. Maresso

Reviewed by preLights

CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis

1. Ipsita Chatterjee
2. Dimitry Getselter
3. Nasreen Ghaneem
4. Shai Bel
5. Evan Elliott

Reviewed by preLights

Coupled Active Systems Encode an Emergent Hunting Behavior in the Unicellular Predator Lacrymaria olor

1. Scott M. Coyle
2. Eliott M. Flaum
3. Hongquan Li
4. Deepak Krishnamurthy
5. Manu Prakash

Reviewed by preLights

On-demand biomanufacturing of protective conjugate vaccines

1. Jessica C. Stark
2. Thapakorn Jaroentomeechai
3. Tyler D. Moeller
4. Jasmine M. Hershewe
5. Katherine F. Warfel
6. Bridget S. Moricz
7. Anthony M. Martini
8. Rachel S. Dubner
9. Karen J. Hsu
10. Taylor C. Stevenson
11. Bradley D. Jones
12. Matthew P. DeLisa
13. Michael C. Jewett

Reviewed by preLights

Molecular and cellular determinants of motor asymmetry in zebrafish

1. Eric J. Horstick
2. Yared Bayleyen
3. Harold A. Burgess

Reviewed by preLights

Membrane bending by protein phase separation

1. Feng Yuan
2. Haleh Alimohamadi
3. Brandon Bakka
4. Andrea N. Trementozzi
5. Nicolas L. Fawzi
6. Padmini Rangamani
7. Jeanne C. Stachowiak

Reviewed by preLights

Neuronal activity drives pathway-specific depolarization of astrocyte distal processes

1. Moritz Armbruster
2. Saptarnab Naskar
3. Jacqueline Garcia
4. Mary Sommer
5. Elliot Kim
6. Yoav Adam
7. Philip G Haydon
8. Edward S Boyden
9. Adam E Cohen
10. Chris G Dulla

Reviewed by preLights

Quantitative Mapping of Human Hair Graying and Reversal in Relation to Life Stress

1. Ayelet Rosenberg
2. Shannon Rausser
3. Junting Ren
4. Eugene Mosharov
5. Gabriel Sturm
6. R Todd Ogden
7. Purvi Patel
8. Rajesh Kumar Soni
9. Clay Lacefield
10. Desmond J Tobin
11. Ralf Paus
12. Martin Picard

• Curated by eLife

  Evaluation Summary:

  This is an interesting and informative study reporting on the molecular features of reversible hair graying in humans and the connection with psychological stress. The study appears to have been very well conducted and the interpretations are generally supported by the data. While the results are primarily correlative at this stage, this work will set the stage for future more mechanistic studies and represents an important conceptual and methodological advance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife, preLights