Evaluated articles

Mechano-dependent sorbitol accumulation supports biomolecular condensate

1. Stephanie Torrino
2. William M Oldham
3. Andrés R Tejedor
4. Ignacio S. Burgos
5. Nesrine Rachedi
6. Kéren Fraissard
7. Caroline Chauvet
8. Chaima Sbai
9. Brendan P. O’Hara
10. Sophie Abélanet
11. Frederic Brau
12. Stephan Clavel
13. Rosana Collepardo-Guevara
14. Jorge R. Espinosa
15. Issam Ben-Sahra
16. Thomas Bertero

Reviewed by preLights

CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity

1. Madison B. Adolph
2. Atharv S. Garje
3. Swati Balakrishnan
4. Florian Morati
5. Mauro Modesti
6. Walter J. Chazin
7. David Cortez

Reviewed by preLights

Proteasome condensate formation is driven by multivalent interactions with shuttle factors and K48-linked ubiquitin chains

1. Kenrick A. Waite
2. Gabrielle Vontz
3. Stella Y. Lee
4. Jeroen Roelofs

Reviewed by preLights

A Phosphoproteomics Data Resource for Systems-level Modeling of Kinase Signaling Networks

1. Song Feng
2. James A. Sanford
3. Thomas Weber
4. Chelsea M. Hutchinson-Bunch
5. Panshak P. Dakup
6. Vanessa L. Paurus
7. Kwame Attah
8. Herbert M. Sauro
9. Wei-Jun Qian
10. H. Steven Wiley

Reviewed by preLights

H ₂ O ₂ sulfenylates CHE linking local infection to establishment of systemic acquired resistance

1. Lijun Cao
2. Heejin Yoo
3. Tianyuan Chen
4. Musoki Mwimba
5. Xing Zhang
6. Xinnian Dong

Reviewed by preLights

Coordinated regulation of photosynthesis and translation via NIK1/RPL10/LIMYB signaling module in response to biotic and abiotic stresses

1. Ruan M. Teixeira
2. Marco Aurélio Ferreira
3. Otávio J.B. Brustolini
4. Thainá F.F. Saia
5. James Jean-Baptiste
6. Samera S. Breves
7. Igor N. Soares
8. Nathalia G.A. Ribeiro
9. Christiane E. M. Duarte
10. Lucas L. Lima
11. Leandro Licursi Oliveira
12. Humberto J.O. Ramos
13. Pedro A.B. Reis
14. Elizabeth P. B. Fontes

Reviewed by preLights

Similarity metric learning on perturbational datasets improves functional identification of perturbations

1. Ian Smith
2. Petr Smirnov
3. Benjamin Haibe-Kains

Reviewed by preLights

PYCR1 Levels Track with Premature and Chronological Skin Aging

1. Kortessa Sotiropoulou
2. Saniye Yumlu
3. Tomoko Hirano
4. Michael Maier
5. Abigail Loh
6. Peh Fern Ong
7. Onn Siong Yim
8. Chunping Liu
9. Emmanuel Vial
10. Umut Altunoğlu
11. Sheela Nampoothiri
12. Deepthi de Silva
13. Björn Fischer-Zirnsak
14. Hülya Kayserili
15. Poh San Lai
16. Oliver Dreesen
17. Kenji Kabashima
18. Uwe Kornak
19. Nathalie Escande-Beillard
20. Bruno Reversade

• Curated by eLife

  eLife assessment

  This manuscript uses genetic mouse modeling to delve deeper into a rare human disease of aging. The targeted approaches employed lend greater pathophysiologic insight and makes this paper valuable to the field art large. Additionally, the approaches used are rigorous and solid in supporting their conclusions. Some minor weaknesses were noted along with suggestions to add greater clarity.

Reviewed by eLife, preLights

The landscape of biomedical research

1. Rita González-Márquez
2. Luca Schmidt
3. Benjamin M. Schmidt
4. Philipp Berens
5. Dmitry Kobak

Reviewed by preLights

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

1. Astrid Hendriks
2. Priscilla F. Kerkman
3. Meri R.J. Varkila
4. Jelle L.G. Haitsma-Mulier
5. Sara Ali
6. Thijs ten Doesschate
7. Thomas W. van der Vaart
8. Carla J.C. de Haas
9. Piet C. Aerts
10. Olaf L. Cremer
11. Marc J.M. Bonten
12. Victor Nizet
13. George Y. Liu
14. Jeroen D.C. Codée
15. Suzan H.M. Rooijakkers
16. Jos A.G. van Strijp
17. Nina M. van Sorge

Reviewed by preLights

Small extracellular vesicles promote stiffness-mediated metastasis

1. Alexandra Sneider
2. Ying Liu
3. Bartholomew Starich
4. Wenxuan Du
5. Carolyn Marar
6. Najwa Faqih
7. Gabrielle E. Ciotti
8. Joo Ho Kim
9. Sejal Krishnan
10. Salma Ibrahim
11. Muna Igboko
12. Alexus Locke
13. Daniel M. Lewis
14. Hanna Hong
15. Michelle Karl
16. Raghav Vij
17. Gabriella C. Russo
18. Praful Nair
19. Estibaliz Gómez-de-Mariscal
20. Mehran Habibi
21. Arrate Muñoz-Barrutia
22. Luo Gu
23. T.S. Karin Eisinger-Mathason
24. Denis Wirtz

Reviewed by preLights

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

1. Fatima Rizvi
2. Yu-Ri Lee
3. Ricardo Diaz-Aragon
4. Pushpinder S. Bawa
5. Juhoon So
6. Rodrigo M. Florentino
7. Susan Wu
8. Arianna Sarjoo
9. Emily Truong
10. Anna R. Smith
11. Feiya Wang
12. Elissa Everton
13. Alina Ostrowska
14. Kyounghwa Jung
15. Ying Tam
16. Hiromi Muramatsu
17. Norbert Pardi
18. Drew Weissman
19. Alejandro Soto-Gutierrez
20. Donghun Shin
21. Valerie Gouon-Evans

Reviewed by preLights

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

1. Joshua Okletey
2. Dimitrios Angelis
3. Tia M. Jones
4. Cristina Montagna
5. Elias T. Spiliotis

Reviewed by preLights

Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death

1. Yupu Wang
2. Ruiling Zhang
3. Sihao Huang
4. Parisa Tajalli-Tehrani Valverde
5. Meike Lobb-Rabe
6. James Ashley
7. Lalanti Venkatasubramanian
8. Robert A. Carrillo

Reviewed by preLights

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1. Avi J. Samelson
2. Nabeela Ariqat
3. Justin McKetney
4. Gita Rohanitazangi
5. Celeste Parra Bravo
6. Darrin Goodness
7. Ruilin Tian
8. Parker Grosjean
9. Romany Abskharon
10. David Eisenberg
11. Nicholas M. Kanaan
12. Li Gan
13. Carlo Condello
14. Danielle L. Swaney
15. Martin Kampmann

Reviewed by preLights

Generating human neural diversity with a multiplexed morphogen screen in organoids

1. Neal D. Amin
2. Kevin W. Kelley
3. Jin Hao
4. Yuki Miura
5. Genta Narazaki
6. Tommy Li
7. Patrick McQueen
8. Shravanti Kulkarni
9. Sergey Pavlov
10. Sergiu P. Paşca

Reviewed by preLights

The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

1. Lydia Gruber
2. Rafael Cantera
3. Markus William Pleijzier
4. Michael Steinert
5. Thomas Pertsch
6. Bill S. Hansson
7. Jürgen Rybak

• Curated by eLife

  eLife assessment

  This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the sub-field. The methodology is solid, but technical limitations require that claims regarding local interneurons be tempered as they were grouped with other neuron types for analyses, and with only one sample from each glomerulus, it is difficult to assess the import of differences between glomeruli without measures of inter-animal variability.

Reviewed by eLife, preLights

Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant

1. Nanami Senoo
2. Dinesh K. Chinthapalli
3. Matthew G. Baile
4. Vinaya K. Golla
5. Bodhisattwa Saha
6. Oluwaseun B. Ogunbona
7. James A. Saba
8. Teona Munteanu
9. Yllka Valdez
10. Kevin Whited
11. Dror Chorev
12. Nathan N. Alder
13. Eric R. May
14. Carol V. Robinson
15. Steven M. Claypool

Reviewed by preLights

Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells

1. Louise Schenberg
2. Aïda Palou
3. François Simon
4. Tess Bonnard
5. Charles-Elliot Barton
6. Desdemona Fricker
7. Michele Tagliabue
8. Jordi Llorens
9. Mathieu Beraneck

• Curated by eLife

  eLife assessment

  This paper provides a fundamental expansion of vestibular compensation into transient and partial dysfunction, as well as insights into the adaptation of visual reflexes in this process. The conclusions are convincingly supported with paired histological and behavioral measurements, which are additionally modeled for further interpretation. This work would be of interest to neuroscientists working in multisensory integration and recovery mechanisms.

Reviewed by eLife, preLights

Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart

1. Chiemela Ohanele
2. Jessica N. Peoples
3. Anja Karlstaedt
4. Joshua T. Geiger
5. Ashley D. Gayle
6. Nasab Ghazal
7. Fateemaa Sohani
8. Milton E. Brown
9. Michael E. Davis
10. George A. Porter
11. Victor Faundez
12. Jennifer Q. Kwong

Reviewed by preLights