Evaluated articles

NASP functions in the cytoplasm to prevent histone H3 aggregation during early embryogenesis

1. Mohit Das
2. Eli Coronado-Chavez
3. Anusha D. Bhatt
4. Reyhaneh Tirgar
5. Amanda A. Amodeo
6. Jared T. Nordman

Reviewed by Review Commons

Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease

1. Antonin Lamazière
2. Lucie Kozlowski
3. Jesus Ayala-Sanmartin
4. Manal Farhat
5. Nabil Belaid
6. Alexandre Certain
7. Bertrand Isidor
8. Thomas Besnard
9. Germain Trugnan
10. Gregory J Pazour
11. Gaëtan Després
12. Céline Deseille
13. Sarah Moreno
14. Thibaut Eguether

Reviewed by Review Commons

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

1. Rianne G Bouma
2. Willem-Jan de Leeuw
3. Aru Z Wang
4. Muddassir Malik
5. Joeke GC Stolwijk
6. Veronique AL Konijn
7. Anne Mensink
8. Natalie Proost
9. Maarten K Nijen Twilhaar
10. Tibor van Welsem
11. Negisa Seyed Toutounchi
12. Alsya J Affandi
13. Jip T van Dinter
14. Fred van Leeuwen
15. Joke MM den Haan

Reviewed by Review Commons

CIP2A Mediates the Recruitment of the SLX4-MUS81-XPF Tri-Nuclease Complex in Mitosis and Protects Against Replication Stress

1. Alice Meroni
2. Annica Pellizzari
3. Andrea Hänel
4. Nathalie Varisco
5. Pascale Brasier-Lutz
6. Isabell Witzel
7. Alessandro A Sartori
8. Manuel Stucki

Reviewed by Review Commons

Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

1. Ioakeim Ampartzidis
2. Elliott M Thompson
3. Yashica Gupta
4. Andrea Krstevski
5. Nicola Elvassore
6. Eirini Maniou
7. Paolo de Coppi
8. Gabriel L Galea

• Curated by eLife

  eLife Assessment

  The authors used genetic mutations in VANGL2 to study cell morphological changes during differentiation of hPSCs and understand the mechanisms underlying neural tube closure defects. The findings are important as they establish a quantitative, reproducible 2D human iPSC-to-neural-progenitor platform for analyzing cell-shape dynamics during differentiation. The convincing evidence provided, combined with the relative simplicity of the model and its tractability as a patient-specific and reverse genetic platform, make it attractive.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

NudC moonlights in ribosome biogenesis and homeostasis in Drosophila melanogaster polyploid cells

1. Duoduo Shi
2. Yuko Shimada-Niwa
3. Naoki Okamoto
4. Akira Nakamura
5. Yuya Ohhara
6. Wei Sun
7. Ryusuke Niwa

Reviewed by Review Commons

Ciliary and non-ciliary functions of CEP104 in Xenopus

1. Panagiota Louka
2. Louiza Potamiti
3. Mihalis I. Panayiotidis
4. Paris Skourides

Reviewed by Review Commons

Condensin II collaborates with cohesin to establish and maintain interphase chromosome territories

1. Takao Ono
2. Masatoshi Takagi
3. Hideyuki Tanabe
4. Tomoko Fujita
5. Noriko Saitoh
6. Akatsuki Kimura
7. Tatsuya Hirano

Reviewed by Review Commons

Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates

1. Allyson H. Turner
2. Sara A. Jaffrani
3. Hannah C. Kubinski
4. Deborah P. Ajayi
5. Matthew B. Owens
6. Conor D. Fanuele
7. Madeline P. McTigue
8. Cailey L. Appenzeller
9. Addington Bowling
10. Hannah W. Despres
11. Madaline M. Schmidt
12. Dave J. Shirley
13. Jessica W. Crothers
14. Ramiro Barrantes-Reynolds
15. Emily A. Bruce

Reviewed by Review Commons

The dynamics of ciliogenesis in prepubertal mouse meiosis reveal new clues about testicular maturation during puberty

1. I Pérez-Moreno
2. P López-Jiménez
3. H Zapata
4. S Pérez-Martín
5. M López-Panadés
6. B Barbeito
7. J Urtasun-Elizari
8. I Roig
9. FR Garcia-Gonzalo
10. J Page
11. R Gómez

Reviewed by Review Commons

Complementary Volume Electron Microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges of D. melanogaster

1. Irina Kolotuev
2. Abigayle Williams
3. Caroline Kizilyaprak
4. Stephanie Pellegrino
5. Lindsay Lewellyn

Reviewed by Review Commons

ParTIpy: A Scalable Framework for Archetypal Analysis and Pareto Task Inference

1. Philipp S. L. Schäfer
2. Leoni Zimmermann
3. Paul L. Burmedi
4. Avia Walfisch
5. Noa Goldenberg
6. Shira Yonassi
7. Einat Shaer Tamar
8. Miri Adler
9. Jovan Tanevski
10. Ricardo O. Ramirez Flores
11. Julio Saez-Rodriguez

Reviewed by Review Commons

Kinetic properties of optogenetic site-specific DNA recombination by LiCre- loxP

1. Alice Dufour
2. Hélène Duplus-Bottin
3. Thomas Boukéké-Lesplulier
4. Eliane Casassa
5. Gérard Triqueneaux
6. Léo Tarbouriech
7. Camille Darthenay-Kiennemann
8. Agnès Dumont
9. Catherine Moali
10. Franck Vittoz
11. Daniel Jost
12. Gaël Yvert

Reviewed by Review Commons

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

1. Roberta Carloni
2. Tadhg Devlin
3. Pin Tong
4. Christos Spanos
5. Tanya Auchynnikava
6. Juri Rappsilber
7. Keith R Matthews
8. Robin C Allshire

• Curated by eLife

  eLife Assessment

  This work significantly advances our understanding of chromatin organization within regions of repetitive sequences in the parasitic protozoan Trypanosoma brucei. Using cutting edge interdisciplinary tools, the authors provide compelling evidence for two discrete types of repetitive DNA element-associated proteins- one set involved in essential centromere function; and, the other involved in glycoprotein antigenic variation via homologous recombination. Thus, these fundamental findings have implications for this parasite's biology, and for therapeutic targeting in kinetoplastid diseases. This work will be exciting to those in the centromere/mitosis and parasite immunity fields.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Idiosyncratic and generic single nuclei and spatial transcriptional patterns in papillary and anaplastic thyroid cancers

1. Adrien Tourneur
2. Joel Rodrigues Vitória
3. Manuel Saiselet
4. Ligia Craciun
5. Denis Larsimont
6. Anne Lefort
7. Frederick Libert
8. Carine Maenhaut
9. Sabine Costagliola
10. Maxime Tarabichi
11. Mirian Romitti
12. Vincent Detours

Reviewed by Review Commons

Heat-off responses of epidermal cells sensitize Drosophila larvae to noxious inputs

1. Jiro Yoshino
2. Avery Chiu
3. Takeshi Morita
4. Chang Yin
5. Federico M. Tenedini
6. Takaaki Sokabe
7. Kazuo Emoto
8. Jay Z. Parrish

Reviewed by Review Commons

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

1. Michaela Veliova
2. Caroline M. Ferreira
3. Katrina P. Montales
4. Francisco Villalobos
5. Alexandra J. Brownstein
6. Rebeca Acín‐Pérez
7. Gabrielly S. Ferreira
8. Anthony E. Jones
9. Linsey Stiles
10. Ajit S. Divakaruni
11. Marc Liesa
12. Orian S. Shirihai
13. Marcus F. Oliveira

Reviewed by Review Commons

Dachsous-Fat Signaling Shapes the Drosophila Wing through Mechanical Forces

1. Bipin Kumar Tripathi
2. Zhenru Zhou
3. Kenneth D. Irvine

Reviewed by Review Commons

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing

1. Ankit Pandey
2. Helene Cousin
3. Shiv Kumar
4. Louis Taylor
5. Ashmita Chander
6. Kelsey Coppenrath
7. Nikko-Ideen Shaidani
8. Marko Horb
9. Dominique Alfandari

Reviewed by Review Commons

Corneal lens curvature depends on localized chitin secretion

1. Neha Ghosh
2. Jessica E. Treisman

Reviewed by Review Commons