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  1. Subcellular Region Morphology Reflects Cellular Identity

    This article has 8 authors:
    1. Ángel-Carlos Román
    2. Alba Diaz-Pizarro
    3. Nuria Del Valle-Del Pino
    4. Marcos Olivera-Gómez
    5. Guadalupe Cumplido-Laso
    6. Dixan Agustín Benítez
    7. Jose María Carvajal-González
    8. Sonia Mulero-Navarro

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei

    This article has 21 authors:
    1. Mohammad Zeeshan
    2. Igor Blatov
    3. Ryuji Yanase
    4. David JP Ferguson
    5. Sarah L Pashley
    6. Zeinab Chahine
    7. Yoshiki Yamaryo-Botté
    8. Akancha Mishra
    9. Baptiste Marche
    10. Suhani Bhanvadia
    11. Molly Hair
    12. Sagar Batra
    13. Robert Markus
    14. Declan Brady
    15. Andrew R Bottrill
    16. Sue Vaughan
    17. Cyrille Y Botté
    18. Karine G Le Roch
    19. Anthony A Holder
    20. Eelco Tromer
    21. Rita Tewari
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In Plasmodium male gametocytes, rapid nuclear division occurs with an intact nuclear envelope, requiring precise coordination between nuclear and cytoplasmic events to ensure proper packaging of each nucleus into a developing gamete. This valuable study characterizes two proteins involved in the formation of Plasmodium berghei male gametes. By integrating live-cell imaging, ultrastructural expansion microscopy, and proteomics, this study convincingly identifies SUN1 and its interaction partner ALLAN as crucial nuclear envelope components in male gametogenesis. A role for SUN1 in membrane dynamics and lipid metabolism is less well supported. The results are of interest for general cell biologists working on unusual mitosis pathways.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 8 evaluationsAppears in 2 listsLatest version Latest activity
  3. The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus

    This article has 19 authors:
    1. Ebba Rosendal
    2. Kyrylo Bisikalo
    3. Stefanie M.A. Willekens
    4. Marie Lindgren
    5. Jiří Holoubek
    6. Pavel Svoboda
    7. Amanda Lappalainen
    8. Ebba Könighofer
    9. Ekaterina Mirgorodskaya
    10. Rickard Nordén
    11. Federico Morini
    12. William Rosenbaum
    13. Daniel Růžek
    14. Ulf Ahlgren
    15. Maria Anastasina
    16. Andres Merits
    17. Sarah J Butcher
    18. Emma Nilsson
    19. Anna K Överby

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

    This article has 3 authors:
    1. Liuqun Zhao
    2. Tanel Punga
    3. Suparna Sanyal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates the molecular mechanisms by which the p53 isoforms Δ133p53α and Δ160p53α exert dominant-negative effects on full-length p53 (FLp53). Through a combination of chromatin immunoprecipitation, transcriptional reporter assays, subcellular localization analyses, and protein aggregation experiments, the authors provide solid evidence that these N-terminally truncated isoforms promote co-aggregation with FLp53, disrupting its transcriptional activity and cellular distribution. The revised manuscript successfully addresses prior reviewer concerns, and the findings are well supported by the experimental data.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 8 evaluationsAppears in 2 listsLatest version Latest activity
  5. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

    This article has 5 authors:
    1. Ryo Egawa
    2. Kota Hiraga
    3. Ryosuke Matsui
    4. Dai Watanabe
    5. Hiroshi Kuba
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 13 evaluationsAppears in 2 listsLatest version Latest activity