Evaluated articles

LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death

1. Andres Goldman
2. Mai Nguyen
3. Joel Lanoix
4. Chongyang Li
5. Ahmed Fahmy
6. Yong Zhong Xu
7. Erwin Schurr
8. Pierre Thibault
9. Michel Desjardins
10. Heidi M. McBride

Reviewed by Review Commons

Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex

1. Ophélie J Gosselin
2. Michael Taschner
3. Lea M Huber-Hürlimann
4. Markus A Seeger
5. Stephan Gruber

• Curated by eLife

  eLife Assessment

  This important study introduces an innovative synthetic nanobody approach to probe the function of the bacterial SMC complex. The work is a compelling example of the potential of this approach. The authors generate protein chimeras to provide convincing evidence that their identified nanobodies target the coiled-coil region of the SMC subunit, demonstrating that this region is critical for SMC function in vivo. Overall, the work is significant for the fields of genome organisation, SMC protein biology, synthetic biology, and bacterial cell biology.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Macrophages maintain signaling fidelity in response to ligand mixtures

1. Xiaolu Guo
2. Supriya Sen
3. Julian Gonzalez
4. Alexander Hoffmann

Reviewed by Review Commons

The role of MICOS in organizing mitochondrial cristae in malaria parasites

1. Silvia Tassan-Lugrezin
2. Irina Bregy
3. Judith López Orra
4. Nicholas I Proellochs
5. Geert-Jan van Gemert
6. Rianne Stoter
7. Felix Evers
8. Taco WA Kooij
9. Laura van Niftrik

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into mitochondrial cristae organization in Plasmodium falciparum, particularly in the context of its divergent MICOS composition. The authors present convincing evidence, supported by phenotypic and morphological analyses, that cristae junction maintenance can be uncoupled from de novo cristae formation, reinforcing an emerging model of mitochondrial inner membrane organization. Notably, the absence of Mic10 alongside an enlarged and divergent MICOS complex highlights an intriguing evolutionary adaptation, although further characterization of the complex would strengthen the study's overall significance.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Identifying and targeting abnormal mitochondrial localization associated with psychosis

1. Marzieh Haghighi
2. Donna McPhie
3. Mohammad Rohban
4. Erin Weisbart
5. David J Logan
6. Kyle W Karhohs
7. Suzann M Babb
8. Jessica D Ewald
9. Johan Fredin Haslum
10. Caitlin Ravichandran
11. Beth A Cimini
12. Shantanu Singh
13. Bruce M Cohen
14. Anne E Carpenter

Reviewed by Review Commons

Four new Duchenne muscular dystrophy mouse models with clinically relevant exon deletions in the human DMD gene

1. Maaike van Putten
2. Margot Linssen
3. Christa Tanganyika-de Winter
4. Conny M. Brouwers
5. Jill W.C. Claassens
6. Nisha Verwey
7. Max Walsh
8. Tiberiu Loredan Stan
9. Annemieke Aartsma-Rus
10. Peter Hohenstein

Reviewed by Review Commons

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

1. Anna Demarinis
2. Sara Esmaeili
3. Crystall M. D. Swarbrick
4. Simone Ranno
5. Silvia Pavan
6. Jade K. Forwood
7. Brian P. McSharry
8. Martin Pal
9. Enzo Di Iorio
10. Gualtiero Alvisi

Reviewed by Review Commons

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

1. Christina Schmidt
2. Denes Turei
3. Dimitrios Prymidis
4. Macabe Daley
5. Christian Frezza
6. Julio Saez-Rodriguez

Reviewed by Review Commons

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

1. Stefano Sellitto
2. Davide Caredio
3. Matteo Bimbati
4. Giovanni Mariutti
5. Martina Cerisoli
6. Lukas Frick
7. Vangelis Bouris
8. Carlos Omar Oueslati Morales
9. Dalila Laura Vena
10. Sandesh Neupane
11. Federico Baroni
12. Kathi Ging
13. Jiang-An Yin
14. Elena De Cecco
15. Andrea Armani
16. Adriano Aguzzi

Reviewed by Review Commons

Nuclear genome profiling of two species of Epidendrum (Orchidaceae): genome size, repeatome, and ploidy

1. Miguel A Alcalá-Gaxiola
2. Gerardo A Salazar
3. Eric Hágsater
4. Mónica A Flores-Iniestres
5. Lidia I Cabrera
6. Aldo I Aviña-Rivera
7. Pedro Mercado-Ruaro
8. Susana Magallon
9. Carolina Granados Mendoza
10. Aleida Núñez-Ruiz
11. Gloria Soldevila
12. Araxi O Urrutia
13. Rubi N Meza-Lázaro

Reviewed by Review Commons

Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

1. Ginto George
2. Heather P. Harding
3. Richard Kay
4. David Ron
5. Adriana Ordóñez

Reviewed by Review Commons

C is non-coding genetic variation drives gene expression changes in the E. coli and P. aeruginosa pangenomes

1. Bamu F. Damaris
2. Matylda Zietek
3. Jelena Erdmann
4. Athanasios Typas
5. Susanne Häußler
6. Marco Galardini

Reviewed by Review Commons

The mRNA export factor UAP56 is required for dendrite and synapse pruning via actin regulation in Drosophila

1. Samuel Matthew Frommeyer
2. Ulrike Gigengack
3. Sandra Rode
4. Matthew Davies
5. Neele Wolterhoff
6. Sebastian Rumpf

Reviewed by Review Commons

Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions

1. Elena J. Cabral
2. Pablo Andres
3. Geraldin Argandona
4. Paige Duggan
5. Benjamin M. Kuran
6. Kristi E. Miller

Reviewed by Review Commons

Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy

1. Benjamin Liffner
2. Thiago Luiz Alves e Silva
3. Elizabeth Glennon
4. Veronica Primavera
5. Elaine Hoffman
6. Alexis Kaushansky
7. Joel Vega-Rodriguez
8. Sabrina Absalon

Reviewed by Review Commons

Heterochronic scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes

1. Yuki Y. Yamauchi
2. Xuanhao D. Sheu
3. Rafat Tarfder
4. Takuma Kumamoto
5. Jun Hatakeyama
6. Haruka Sato
7. Pauline Rouillard
8. Merve Bilgic
9. Shuto Deguchi
10. Tomonori Nakamura
11. Yusuke Kishi
12. Kazuo Emoto
13. Ikuo K. Suzuki

Reviewed by Review Commons

Functional Profiling of 2,193 ASS1 Missense Variants: Insights into Variant Pathogenicity and Epistatic Interactions in Citrullinemia Type I

1. Russell S. Lo
2. Gareth A. Cromie
3. Michelle Tang
4. Amy Sirr
5. Ljubica Caldovic
6. Hiroki Morizono
7. Nicholas Ah Mew
8. Andrea Gropman
9. Aimée M. Dudley

Reviewed by Review Commons

IP3R2 mediated inter-organelle Ca ²⁺ signaling orchestrates melanophagy

1. Suman Saurav
2. Rajender K Motiani

Reviewed by Review Commons

The Hok bacterial toxin: diversity, toxicity, distribution and genomic localization

1. Andrés Escalera-Maurer
2. Adriana Messineo
3. Thibaud T. Renault
4. Elena Nicollin
5. Erika Castaneda-Sastre
6. Matthieu Brunot
7. Cléo Berrehail
8. Anaïs Le Rhun

Reviewed by Review Commons

Dynamics of bicoid mRNA localisation and translation dictate morphogen gradient formation

1. T. Athilingam
2. E.L. Wilby
3. P. Bensidoun
4. A. Trullo
5. M. Verbrugghe
6. X. Shi
7. M. Lagha
8. T.E. Saunders
9. T.T. Weil

Reviewed by Review Commons