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  1. Mesoscale functional architecture in medial posterior parietal cortex

    This article has 7 authors:
    1. Riichiro Hira
    2. Leah B Townsend
    3. Ikuko T Smith
    4. Che-Hang Yu
    5. Jeffrey N Stirman
    6. Yiyi Yu
    7. Spencer LaVere Smith
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study measures the functional specialization of distinct subregions within the mouse posterior parietal cortex (PPC) using mesoscopic two-photon calcium imaging during visual discrimination and choice history-dependent tasks. It presents compelling evidence supporting the existence of functional specialized subregions within the PPC. The work will be of interest to system and computational neuroscientists interested in decision-making, working memory, and multisensory integration.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia

    This article has 13 authors:
    1. Takuma Nohara
    2. Junichi Kumamoto
    3. Yosuke Mai
    4. Mayuna Shimano
    5. Sora Kato
    6. Hiroyuki Kitahata
    7. Hideki Nakamura
    8. Shota Takashima
    9. Mika Watanabe
    10. Masaharu Nagayama
    11. Tsukasa Oikawa
    12. Hideyuki Ujiie
    13. Ken Natsuga
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and subsequent mesenchymal-to-epithelial transition (MET) while migrating through a membrane with 3.0-µm micropores, and, thus, provides a valuable tool to study EMT and possibly wound regeneration or metastasis. Furthermore, a set of experiments provides solid data suggesting that TGF beta signaling and actin polymerization promote movement of epithelial cells into the pores, while Piezo1 and Keratin 6 prevent keratinocyte migration and EMT.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Combined transcriptomic, connectivity, and activity profiling of the medial amygdala using highly amplified multiplexed in situ hybridization (hamFISH)

    This article has 15 authors:
    1. Mathew D Edwards
    2. Ziwei Yin
    3. Risa Sueda
    4. Alina Gubanova
    5. Chang S Xu
    6. Virág Lakner
    7. Megan Murchie
    8. Chi-Yu Lee
    9. Kristal Ng
    10. Karolina Farrell
    11. Rupert Faraway
    12. Subham Ganguly
    13. Elina Jacobs
    14. Bogdan Bintu
    15. Yoh Isogai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study presents important findings that are highly relevant for research aiming to combine transcriptomics, connectivity studies, and activity profiling in the rodent brain and the revisions improve the study. The evidence overall remains convincing as the authors use appropriate and validated methodology in line with current state-of-the-art.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity