Showing page 187 of 375 pages of list content

  1. Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

    This article has 11 authors:
    1. Valentin Gfeller
    2. Jan Waelchli
    3. Stephanie Pfister
    4. Gabriel Deslandes-Hérold
    5. Fabio Mascher
    6. Gaetan Glauser
    7. Yvo Aeby
    8. Adrien Mestrot
    9. Christelle AM Robert
    10. Klaus Schlaeppi
    11. Matthias Erb
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents findings that are important for understanding plant-soil feedbacks in agriculture. The authors use a large-scale agricultural field experiment to demonstrate the role of root-emitted secondary metabolites in enhancing the yield of the next crop. By using a benzoxazinoid-deficient maize genotype, the authors provide compelling evidence that biomass production and grain yield of several wheat varieties can be increased when grown in soil conditioned by maize plants able to release benzoxazinoids.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
  2. Agonist efficiency links binding and gating in a nicotinic receptor

    This article has 2 authors:
    1. Dinesh C Indurthi
    2. Anthony Auerbach
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work investigates the fundamental concept of how the energy of agonist binding is converted into the energy of the conformational change that opens the pore of a ligand-gated ion channel. The conclusions are based on analysis of solid data in terms of a mechanistic model, but adequate statistical analysis is lacking and the uniqueness of the proposed model is not discussed. The findings will be interesting to biophysicists working on ligand-gated ion channels and, more generally, to enzymologists focused on allosteric enzyme regulation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Large-scale neural dynamics in a shared low-dimensional state space reflect cognitive and attentional dynamics

    This article has 3 authors:
    1. Hayoung Song
    2. Won Mok Shim
    3. Monica D Rosenberg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study examines the distribution of four states of brain activity across a variety of cognitive conditions, linking systems neuroscience with cognition and behavior. The work is convincing, using null models and replication in independent datasets to support their findings.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    This article has 9 authors:
    1. Arjun Rajan
    2. Lucas Anhezini
    3. Noemi Rives-Quinto
    4. Jay Y Chhabra
    5. Megan C Neville
    6. Elizabeth D Larson
    7. Stephen F Goodwin
    8. Melissa M Harrison
    9. Cheng-Yu Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work shows how a transcription factor, fruitless isoform C, fine-tunes the expression of stemness genes to maintain proper stem-cell identity during neurogenesis in Drosophila. The rationale of the work is well-thought-out, conclusions are supported by compelling evidence, and experiments are performed in a rigorous manner, although additional statistics would improve the conclusions. Overall, this work will be of interest to those working on chromatin regulation, transcription regulation, and stem-cell biology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

    This article has 2 authors:
    1. Blanca Jimeno
    2. Simon Verhulst
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work presents a fundamental meta-analysis on the causes of glucocorticoid variations in birds and mammals. It provides convincing evidence that an increase in metabolic rates increases glucocorticoid concentrations. The work will be of broad interest to animal physiologists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level

    This article has 6 authors:
    1. Vilde Olsson Lalun
    2. Maike Breiden
    3. Sergio Galindo-Trigo
    4. Elwira Smakowska-Luzan
    5. RĂŒdiger GW Simon
    6. Melinka A Butenko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript presents valuable findings on the role of a plant peptide in coordinating developmental and immune responses signaling. The evidence supporting the claims, while mainly descriptive and and somewhat limited due to the main conclusions being drawn from overexpression lines, is mostly solid. The findings are interesting, they align with existing models, and they are of relevance to plant pathologists and developmental biologists.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Structure of the Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase from the model microalga Chlamydomonas reinhardtii

    This article has 7 authors:
    1. Théo Le Moigne
    2. Martina Santoni
    3. Lucile Jomat
    4. Stéphane D Lemaire
    5. Mirko Zaffagnini
    6. Nicolas Chéron
    7. Julien Henri
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides a valuable structural analysis of the Sedoheptulose-1,7-Bisphosphatase (SBPase) from Chlamydomonas reinhardtii. The data presented are solid and based on X-ray structures of the CrSBPase in an oxidized and reduced state, the authors identify a disulfide bond in close proximity to the dimer interface. They show that the redox-state of the CrSBPase impacts its oligomeric state and might also influence the activity of the protein.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. Energetics of the microsporidian polar tube invasion machinery

    This article has 7 authors:
    1. Ray Chang
    2. Ari Davydov
    3. Pattana Jaroenlak
    4. Breane Budaitis
    5. Damian C Ekiert
    6. Gira Bhabha
    7. Manu Prakash
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study combines experiments and fluid mechanics modeling to determine the mechanism of the ultrafast ejection of the polar tube of the Microsporidia parasite and of transport through this tube. The methods and the analysis, based on the variation of the viscosity of the external medium, are compelling and allow for the first time to discriminate among proposed ejection mechanisms. This approach where simple physical principles are used for distinguishing between mechanisms when the precise geometry is inaccessible through imaging is potentially applicable to other systems in microbiology.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

    This article has 32 authors:
    1. Denis Dacheux
    2. Guillaume Martinez
    3. Christine E Broster Reix
    4. Julie Beurois
    5. Patrick Lores
    6. Magamba Tounkara
    7. Jean-William Dupuy
    8. Derrick Roy Robinson
    9. Corinne Loeuillet
    10. Emeline Lambert
    11. Zeina Wehbe
    12. Jessica Escoffier
    13. Amir Amiri-Yekta
    14. Abbas Daneshipour
    15. Seyedeh-Hanieh Hosseini
    16. Raoudha Zouari
    17. Selima Fourati Ben Mustapha
    18. Lazhar Halouani
    19. Xiaohui Jiang
    20. Ying Shen
    21. Chunyu Liu
    22. Nicolas Thierry-Mieg
    23. Amandine Septier
    24. Marie Bidart
    25. Véronique Satre
    26. Caroline Cazin
    27. Zine Eddine Kherraf
    28. Christophe Arnoult
    29. Pierre F Ray
    30. Aminata Toure
    31. Mélanie Bonhivers
    32. Charles Coutton
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports the physiological role of ZMYND21 in the regulation of sperm flagellar development and male fertility. The data supporting the conclusion are solid, although the inclusion of more patients and ultrastructural studies would have further strengthened the study. This work will be of interest to clinicians and researchers who work on either sperm biology or ciliopathy due to cilial defects.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    This article has 25 authors:
    1. Joanna C Porter
    2. Jamie Inshaw
    3. Vincente Joel Solis
    4. Emma Denneny
    5. Rebecca Evans
    6. Mia I Temkin
    7. Nathalia De Vasconcelos
    8. Iker Valle Aramburu
    9. Dennis Hoving
    10. Donna Basire
    11. Tracey Crissell
    12. Jesusa Guinto
    13. Alison Webb
    14. Hanif Esmail
    15. Victoria Johnston
    16. Anna Last
    17. Thomas Rampling
    18. Lena Lippert
    19. Elisa Theresa Helbig
    20. Florian Kurth
    21. Bryan Williams
    22. Aiden Flynn
    23. Pauline T Lukey
    24. Veronique Birault
    25. Venizelos Papayannopoulos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This small-sized clinical trial comparing nebulized dornase-alfa to the best available care in patients hospitalized with COVID-19 pneumonia is valuable, but in its present form the paper is incomplete.

    Reviewed by eLife, Rapid Reviews Infectious Diseases, ScreenIT

    This article has 12 evaluationsAppears in 5 listsLatest version Latest activity
  11. Microplastics are present in women’s and cows’ follicular fluid and polystyrene microplastics compromise bovine oocyte function in vitro

    This article has 9 authors:
    1. Nicole Grechi
    2. Roksan Franko
    3. Roshini Rajaraman
    4. Jan B. Stöckl
    5. Tom Trapphoff
    6. Stefan Dieterle
    7. Thomas Fröhlich
    8. Michael J. Noonan
    9. Marcia de A. M. M. Ferraz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript represents a valuable study showing that microplastics indeed accumulate in both bovine and human ovarian follicular fluid. It also presented data that direct exposure of bovine eggs to polystyrene, a microplastic commonly found in follicular fluid, negatively affects oocyte maturation, probably through the downregulation of key proteins involved in oxidative stress, DNA damage, apoptosis, and oocyte maturation. Despite the solid supporting evidence, inclusion of the demographics and reasons for assisted reproduction of the human subjects used, as well as the details on quality control for proteomic analyses would further strengthen the study. The work will be of interest to reproductive toxicologists, regulatory scientists and reproductive health care professionals.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  12. Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through OpenSAFELY

    This article has 48 authors:
    1. Louis Fisher
    2. Helen J Curtis
    3. Richard Croker
    4. Milan Wiedemann
    5. Victoria Speed
    6. Christopher Wood
    7. Andrew Brown
    8. Lisa EM Hopcroft
    9. Rose Higgins
    10. Jon Massey
    11. Peter Inglesby
    12. Caroline E Morton
    13. Alex J Walker
    14. Jessica Morley
    15. Amir Mehrkar
    16. Seb Bacon
    17. George Hickman
    18. Orla Macdonald
    19. Tom Lewis
    20. Marion Wood
    21. Martin Myers
    22. Miriam Samuel
    23. Robin Conibere
    24. Wasim Baqir
    25. Harpreet Sood
    26. Charles Drury
    27. Kiren Collison
    28. Chris Bates
    29. David Evans
    30. Iain Dillingham
    31. Tom Ward
    32. Simon Davy
    33. Rebecca M Smith
    34. William Hulme
    35. Amelia Green
    36. John Parry
    37. Frank Hester
    38. Sam Harper
    39. Jonathan Cockburn
    40. Shaun O'Hanlon
    41. Alex Eavis
    42. Richard Jarvis
    43. Dima Avramov
    44. Paul Griffiths
    45. Aaron Fowles
    46. Nasreen Parkes
    47. Brian MacKenna
    48. Ben Goldacre
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper presents an important effort to develop an open source software framework for monitoring trends and variations in healthcare over time in England. They demonstrate a compelling example of how this system can track key health care indicators over the course of the COVID-19 pandemic. The paper will likely be mainly of interest to stakeholders in England, but could inspire the creation of similar systems in other countries.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  13. Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

    This article has 4 authors:
    1. Geoffroy Delamare
    2. Yosif Zaki
    3. Denise J Cai
    4. Claudia Clopath
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important theoretical study providing insight into how fluctuations in excitability can contribute to gradual changes in the mapping between population activity and stimulus, commonly referred to as representational drift. The authors provide convincing evidence that fluctuations can contribute to drift. Overall, this is a well-presented study that explores the question of how changes in intrinsic excitability can influence distinct memory representations.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  14. Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster

    This article has 5 authors:
    1. Jierui Qin
    2. Tingting Yang
    3. Kexin Li
    4. Ting Liu
    5. Wei Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study investigates the role of mechanosensory feedback during swallowing in adult Drosophila. The authors provide convincing evidence that three mechanotransduction channel genes are required for ingestion rhythms and localize the role of these genes to a specific subpopulation of pharyngeal mechanosensory neurons. However, there is incomplete evidence to support the conclusions that these sensory neurons are necessary for swallowing, respond to stretch during swallowing, and connect to the motor neurons that control swallowing. This work may be of interest to neuroscientists interested in motor control of feeding behavior.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  15. Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    This article has 11 authors:
    1. Aixin Zhang
    2. Lei Jin
    3. Shenqin Yao
    4. Makoto Matsuyama
    5. Cindy TJ van Velthoven
    6. Heather Anne Sullivan
    7. Na Sun
    8. Manolis Kellis
    9. Bosiljka Tasic
    10. Ian Wickersham
    11. Xiaoyin Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents an important tool for tracking the connectivity of neurons in mouse and potentially other mammals using a combined approach of barcoded rabies virus libraries and spatial transcriptomics. The data supporting the technique are convincing, the validation against known anatomical knowledge is rigorous, and the authors advance the techniques by combing them in vivo. Overall, this is a very good paper describing a technique for tracking neural circuits.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  16. Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

    This article has 2 authors:
    1. Hao Li
    2. Xin Jin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable manuscript Li & Jin record from the substantial nigra and dorsal striatum to identify subpopulations of neurons with activity that reflects different dynamics during action selection, and then use optogenetics in transgenic mice to selectively inhibit or excite D1- and D2- expressing spiny projection neurons in the striatum, demonstrating a causal role for each in action selection in an opposing manner. They provide solid evidence for the argument that their findings cannot be explained by current models and propose a new 'triple control' model instead, with one direct and two indirect pathways, although direct evidence for a second indirect pathway is still lacking. These findings will be of broad interest to neuroscientists across multiple subfields.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  17. Hippocampal remapping induced by new behavior is mediated by spatial context

    This article has 2 authors:
    1. Samuel J. Levy
    2. Michael E. Hasselmo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The formation of the place cell map in the hippocampus is foundational to many models and is thought to form a substrate onto which memories can be structured. This paper presents an important new observation to our understanding of place cell formation - namely that task learning changes or interferes with the process of place cell map stabilization. Reviewers found that there was incomplete evidence for this result, however, in this version of the manuscript because of a confound between the duration of experience in an environment and task-specific learning.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  18. Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production

    This article has 3 authors:
    1. Nina K Jain
    2. Pierce J Ogden
    3. George M Church
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable and comprehensive mutagenesis map of the AAV2 rep gene, which will undoubtedly capture the interest of scientists working with adeno-associated viruses and those engaged in the field of gene therapy. The thorough characterization of massive rep variants across multiple AAV production systems bolsters the claims made in the study, highlighting its utility in enhancing our understanding of Rep protein function and advancing gene therapy applications. The evidence presented is convincing and establishes a strong foundation that will stimulate and inform future research in the field.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  19. Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

    This article has 6 authors:
    1. Michele Brischigliaro
    2. Alfredo Cabrera-Orefice
    3. Susanne Arnold
    4. Carlo Viscomi
    5. Massimo Zeviani
    6. Erika FernĂĄndez-Vizarra
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on the organization of respiratory chain complexes in mitochondria. It provides solid evidence that respiratory supercomplex formation in the fruit fly does not impact respiratory function, suggesting the role of these complexes is structural, rather than catalytic. However, whether the conclusions extend to other species requires further evidence. This manuscript will be of broad interest to the field of mitochondrial bioenergetics.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  20. Rice stripe virus utilizes an Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

    This article has 6 authors:
    1. Jing Zhao
    2. Xiangyi Meng
    3. Jie Yang
    4. Rongxiang Fang
    5. Yan Huo
    6. Lili Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a useful set of experiments to test how a salivary protein might facilitate planthopper-transmitted rice stripe virus infection by interfering with callose deposition. If the conclusions can be confirmed, the study will enhance our understanding of the mechanisms mediating tripartite virus-insect vector-plant interactions and would be of general interest in plant science research. Whereas most experimental data is compelling, the conclusions rely on inadequate evidence for the salivary protein carbonic anhydrase being present two weeks post injection in the plant, which seems unlikely.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity