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  1. The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies

    This article has 14 authors:
    1. Conrad En-Zuo Chan
    2. Ching-Ging Ng
    3. Angeline Pei-Chew Lim
    4. Shirley Lay-Kheng Seah
    5. De-Hoe Chye
    6. Steven Ka-Khuen Wong
    7. Jie-Hui Lim
    8. Vanessa Zi-Yun Lim
    9. Soak-Kuan Lai
    10. Pui-San Wong
    11. Kok-Mun Leong
    12. Yi-Chun Liu
    13. Richard J Sugrue
    14. Boon-Huan Tan

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants

    This article has 5 authors:
    1. François Blanquart
    2. Nathanaël Hozé
    3. Benjamin John Cowling
    4. Florence Débarre
    5. Simon Cauchemez
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript will be of broad interest to readers interested in understanding characteristics of variants in ongoing epidemics that lead to faster (or slower) growth rates, and will be of particular interest to those wishing to understand the factors leading to selection of SARS-CoV-2 variants. The transmission advantage of a novel strain of a pathogen depends not only on its relative transmissibility, but also on its generation time relative to other strains; the relation between transmissibility, transmission advantage and generation time changes across different phases of the epidemic, enabling statistical inferences to be made about both the transmissibility advantage and generation time of an emerging variant. The method is supported by simulation studies and applied to the Alpha and Delta SARS-CoV-2 variants to show that selection was likely driven by changes in transmissibility rather than changes in the generation time.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife, ScreenIT

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. Characterization of the interaction between SARS-CoV-2 Membrane Protein and Proliferating Cell Nuclear Antigen (PCNA) as a Potential Therapeutic Target

    This article has 18 authors:
    1. Érika Pereira Zambalde
    2. Isadora Carolina Betim Pavan
    3. Mariana Camargo Silva Mancini
    4. Matheus Brandemarte Severino
    5. Orlando Bonito Scudero
    6. Ana Paula Morelli
    7. Mariene Ribeiro Amorim
    8. Karina Bispo dos Santos
    9. Mariana Marcela GĂłis
    10. Daniel Augusto de Toledo-Teixeira
    11. Pierina Lorencini Parise
    12. Thais Mauad
    13. Marisa Dolhnikoff
    14. Paulo Hilário Nascimento Saldiva
    15. Henrique Marques-Souza
    16. José Luiz Proenca-Modena
    17. Armando Morais Ventura
    18. Fernando Moreira Simabuco

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  4. Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2

    This article has 10 authors:
    1. Karen V. Kibler
    2. Mateusz Szczerba
    3. Douglas Lake
    4. Alexa J. Roeder
    5. Masmudur Rahman
    6. Brenda G. Hogue
    7. Lok-Yin Roy Wong
    8. Stanley Perlman
    9. Yize Li
    10. Bertram L. Jacobs

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  5. The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

    This article has 28 authors:
    1. Tiziana Ginex
    2. Clara Marco-MarĂ­n
    3. Miłosz Wieczór
    4. Carlos P. Mata
    5. James Krieger
    6. Paula Ruiz-Rodriguez
    7. Maria Luisa LĂłpez-Redondo
    8. Clara Francés-Gómez
    9. Roberto Melero
    10. Carlos Óscar Sánchez-Sorzano
    11. Marta MartĂ­nez
    12. Nadine Gougeard
    13. Alicia Forcada-Nadal
    14. Sara Zamora-Caballero
    15. Roberto Gozalbo-Rovira
    16. Carla Sanz-Frasquet
    17. RocĂ­o Arranz
    18. Jeronimo Bravo
    19. Vicente Rubio
    20. Alberto Marina
    21. The IBV-Covid19-Pipeline
    22. Ron Geller
    23. Iñaki Comas
    24. Carmen Gil
    25. Mireia Coscolla
    26. Modesto Orozco
    27. José Luis Llácer
    28. Jose-Maria Carazo

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  6. Relative contribution of leaving home for work or education, transport, shopping and other activities on risk of acquiring COVID-19 infection outside the household in the second wave of the pandemic in England and Wales

    This article has 15 authors:
    1. S Hoskins
    2. S Beale
    3. RW Aldridge
    4. AMD Navaratnam
    5. C Smith
    6. CE French
    7. A Yavlinsky
    8. V Nguyen
    9. T Byrne
    10. J Kovar
    11. E Fragaszy
    12. WLA Fong
    13. C Geismar
    14. P Patel
    15. AM Johnson

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. COVID-19 cluster size and transmission rates in schools from crowdsourced case reports

    This article has 4 authors:
    1. Paul Tupper
    2. Shraddha Pai
    3. COVID Schools Canada
    4. Caroline Colijn
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper is the first to characterize overdispersion of COVID-19 spread in schools using crowdsourcing . It has the potential to serve as a useful platform for assessing preventative measures in schools but needs more clarity regarding the sensitivity of the approach to the completeness of input data, as evidence by different model conclusions when sparse data from the US is used as an input as opposed to the more detailed Canadian data.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    This article has 6 evaluationsAppears in 2 listsLatest version Latest activity
  8. The T-cell clonal response to SARS-CoV-2 vaccination in inflammatory bowel disease patients is augmented by anti-TNF therapy and often deficient in antibody-responders

    This article has 24 authors:
    1. Dalin Li
    2. Alexander Xu
    3. Emebet Mengesha
    4. Rebecca Elyanow
    5. Rachel M. Gittelman
    6. Heidi Chapman
    7. John C. Prostko
    8. Edwin C. Frias
    9. James L. Stewart
    10. Valeriya Pozdnyakova
    11. Philip Debbas
    12. Angela Mujukian
    13. Arash A Horizon
    14. Noah Merin
    15. Sandy Joung
    16. Gregory J. Botwin
    17. Kimia Sobhani
    18. Jane C. Figueiredo
    19. Susan Cheng
    20. Ian M. Kaplan
    21. Dermot P.B. McGovern
    22. Akil Merchant
    23. Gil Y. Melmed
    24. Jonathan Braun

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity