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  1. Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study

    This article has 28 authors:
    1. Naomi F. Walker
    2. Rachel L. Byrne
    3. Ashleigh Howard
    4. Elissavet Nikolaou
    5. Madlen Farrar
    6. Sharon Glynn
    7. Katerina S. Cheliotis
    8. Ana I. Cubas Atienzar
    9. Kelly Davies
    10. Jesús Reiné
    11. Zalina Rashid-Gardner
    12. Esther L. German
    13. Carla Solórzano
    14. Tess Blandamer
    15. Lisa Hitchins
    16. Christopher Myerscough
    17. Bradford D. Gessner
    18. Elizabeth Begier
    19. Andrea M. Collins
    20. Mike Beadsworth
    21. Stacy Todd
    22. Helen Hill
    23. Catherine F. Houlihan
    24. Eleni Nastouli
    25. Emily R. Adams
    26. Elena Mitsi
    27. Daniela M. Ferreira
    28. on behalf of the SAFER investigators

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  2. The Relationship between COVID-19 Severity and Bacillus Calmette-Guérin (BCG)/ Mycobacterium tuberculosis exposure history in healthcare workers: a multi-center study

    This article has 34 authors:
    1. Serife Torun
    2. Sevket Ozkaya
    3. Nazan Şen
    4. Fikret Kanat
    5. Irem Karaman
    6. Sebnem Yosunkaya
    7. Ozlem Sengoren Dikis
    8. Ali Asan
    9. Selma Aydogan Eroglu
    10. Sefa Semih Atal
    11. Omer Ayten
    12. Nimet Aksel
    13. Hilal Ermiş
    14. Neslihan Özçelik
    15. Meryem Demirelli
    16. Iskender Kara
    17. Sua Sümer
    18. Kamile Marakoğlu
    19. Fatih Üzer
    20. Yasin Uyar
    21. Tuba Çiçek
    22. Zuhal E Ünsal
    23. Husamettin Vatansev
    24. Berna Botan Yildirim
    25. Tuba Kuruoğlu
    26. Aynur Atilla
    27. Yasemin Ersoy
    28. Bahar Kandemir
    29. Yasemin Durduran
    30. Fatma Goksin​ Cihan
    31. Nur Demirbaş
    32. Fatma Yıldırım
    33. Dursun Tatar
    34. M Sule Akcay

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  3. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy

    This article has 8 authors:
    1. Sierra M. Barone
    2. Alberta G.A. Paul
    3. Lyndsey M. Muehling
    4. Joanne A. Lannigan
    5. William W. Kwok
    6. Ronald B. Turner
    7. Judith A. Woodfolk
    8. Jonathan M. Irish
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The three reviewers were overly positive about the stated goal of your T-REX method to characterize rare populations by cytometry. The potential applications in the context of analyzing antigen-specific T cells (as identified as tetramer-positive cells) were not missed on the reviewers and the use of the 2 timepoints-cohort of samples from rhinovirus-infected patients was judged clever. However, all three reviewers requested some edits and additional tests to really distinguish T-REX from other methods in terms of performance, and to better understand its analysis power. Reviewer #1 enjoined you to clarify the improvements of your method compared to previous methods. Reviewer #2 requested more stringent tests of your methods against functional datasets. Reviewer #3 inquired about corrections for batch effects, the result consistency for repeated down-sampling as well as the scalability of the method (especially when UMAP is being used).

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

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  4. LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients

    This article has 20 authors:
    1. Giuseppe Bombaci
    2. Mayuresh Anant Sarangdhar
    3. Nicola Andina
    4. Aubry Tardivel
    5. Eric Chi-Wang Yu
    6. Gillian M. Mackie
    7. Matthew Pugh
    8. Vedat Burak Ozan
    9. Yara Banz
    10. Thibaud Spinetti
    11. Cedric Hirzel
    12. Esther Youd
    13. Joerg C. Schefold
    14. Graham Taylor
    15. Amiq Gazdhar
    16. Nicolas Bonadies
    17. Anne Angelillo-Scherrer
    18. Pascal Schneider
    19. Kendle M. Maslowski
    20. Ramanjaneyulu Allam

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  5. REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters

    This article has 34 authors:
    1. Alina Baum
    2. Richard Copin
    3. Dharani Ajithdoss
    4. Anbo Zhou
    5. Kathryn Lanza
    6. Nicole Negron
    7. Min Ni
    8. Yi Wei
    9. Gurinder S. Atwal
    10. Adelekan Oyejide
    11. Yenny Goez-Gazi
    12. John Dutton
    13. Elizabeth Clemmons
    14. Hilary M. Staples
    15. Carmen Bartley
    16. Benjamin Klaffke
    17. Kendra Alfson
    18. Michal Gazi
    19. Olga Gonzales
    20. Edward Dick
    21. Ricardo Carrion
    22. Laurent Pessaint
    23. Maciel Porto
    24. Anthony Cook
    25. Renita Brown
    26. Vaneesha Ali
    27. Jack Greenhouse
    28. Tammy Taylor
    29. Hanne Andersen
    30. Mark G. Lewis
    31. Neil Stahl
    32. Andrew J. Murphy
    33. George D. Yancopoulos
    34. Christos A. Kyratsous

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  6. Centenarians and extremely old people living with frailty can elicit durable SARS-CoV-2 spike specific IgG antibodies with virus neutralization functions following virus infection as determined by serological study

    This article has 19 authors:
    1. Mary K. Foley
    2. Samuel D. Searle
    3. Ali Toloue
    4. Ryan Booth
    5. Alec Falkenham
    6. Darryl Falzarano
    7. Salvatore Rubino
    8. Magen E. Francis
    9. Mara McNeil
    10. Christopher Richardson
    11. Jason LeBlanc
    12. Sharon Oldford
    13. Volker Gerdts
    14. Melissa K. Andrew
    15. Shelly A. McNeil
    16. Barry Clarke
    17. Kenneth Rockwood
    18. David J. Kelvin
    19. Alyson A. Kelvin

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  7. Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

    This article has 29 authors:
    1. Ludovico Cantuti-Castelvetri
    2. Ravi Ojha
    3. Liliana D. Pedro
    4. Minou Djannatian
    5. Jonas Franz
    6. Suvi Kuivanen
    7. Franziska van der Meer
    8. Katri Kallio
    9. Tuğberk Kaya
    10. Maria Anastasina
    11. Teemu Smura
    12. Lev Levanov
    13. Leonora Szirovicza
    14. Allan Tobi
    15. Hannimari Kallio-Kokko
    16. Pamela Österlund
    17. Merja Joensuu
    18. Frédéric A. Meunier
    19. Sarah J. Butcher
    20. Martin Sebastian Winkler
    21. Brit Mollenhauer
    22. Ari Helenius
    23. Ozgun Gokce
    24. Tambet Teesalu
    25. Jussi Hepojoki
    26. Olli Vapalahti
    27. Christine Stadelmann
    28. Giuseppe Balistreri
    29. Mikael Simons

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  8. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

    This article has 44 authors:
    1. Kami Pekayvaz
    2. Alexander Leunig
    3. Rainer Kaiser
    4. Markus Joppich
    5. Sophia Brambs
    6. Aleksandar Janjic
    7. Oliver Popp
    8. Daniel Nixdorf
    9. Valeria Fumagalli
    10. Nora Schmidt
    11. Vivien Polewka
    12. Afra Anjum
    13. Viktoria Knottenberg
    14. Luke Eivers
    15. Lucas E. Wange
    16. Christoph Gold
    17. Marieluise Kirchner
    18. Maximilian Muenchhoff
    19. Johannes C. Hellmuth
    20. Clemens Scherer
    21. Raquel Rubio-Acero
    22. Tabea Eser
    23. Flora Deák
    24. Kerstin Puchinger
    25. Niklas Kuhl
    26. Andreas Linder
    27. Kathrin Saar
    28. Lukas Tomas
    29. Christian Schulz
    30. Andreas Wieser
    31. Wolfgang Enard
    32. Inge Kroidl
    33. Christof Geldmacher
    34. Michael von Bergwelt-Baildon
    35. Oliver T. Keppler
    36. Mathias Munschauer
    37. Matteo Iannacone
    38. Ralf Zimmer
    39. Philipp Mertins
    40. Norbert Hubner
    41. Michael Hoelscher
    42. Steffen Massberg
    43. Konstantin Stark
    44. Leo Nicolai

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  9. The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients

    This article has 20 authors:
    1. Elisa Teyssou
    2. Cathia Soulie
    3. Benoit Visseaux
    4. Sidonie Lambert-Niclot
    5. Valentine Ferre
    6. Stéphane Marot
    7. Aude Jary
    8. Sophie Sayon
    9. Karen Zafilaza
    10. Valentin Leducq
    11. Aurélie Schnuriger
    12. Basma Abdi
    13. Marc Wirden
    14. Nadhira Houhou-Fidouh
    15. Charlotte Charpentier
    16. Laurence Morand-Joubert
    17. Sonia Burrel
    18. Diane Descamps
    19. Vincent Calvez
    20. Anne Geneviève Marcelin

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  10. Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells

    This article has 26 authors:
    1. Matthew J. Dean
    2. Juan B. Ochoa
    3. Maria Dulfary Sanchez-Pino
    4. Jovanny Zabaleta
    5. Jone Garai
    6. Luis Del Valle
    7. Dorota Wyczechowska
    8. Lyndsey Buckner Baiamonte
    9. Phaethon Philbrook
    10. Rinku Majumder
    11. Richard S. Vander Heide
    12. Logan Dunkenberger
    13. Ramesh Puttalingaiah Thylur
    14. Bobby Nossaman
    15. W. Mark Roberts
    16. Andrew G. Chapple
    17. Jiande Wu
    18. Chindo Hicks
    19. Jack Collins
    20. Brian Luke
    21. Randall Johnson
    22. Hari K. Koul
    23. Chris A. Rees
    24. Claudia R. Morris
    25. Julia Garcia-Diaz
    26. Augusto C. Ochoa

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