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  1. SARS-CoV-2 uses CD4 to infect T helper lymphocytes

    This article has 76 authors:
    1. Natalia S Brunetti
    2. Gustavo G Davanzo
    3. Diogo de Moraes
    4. Allan JR Ferrari
    5. Gabriela F Souza
    6. Stéfanie Primon Muraro
    7. Thiago L Knittel
    8. Vinicius O Boldrini
    9. Lauar B Monteiro
    10. João Victor Virgílio-da-Silva
    11. Gerson S Profeta
    12. Natália S Wassano
    13. Luana Nunes Santos
    14. Victor C Carregari
    15. Artur HS Dias
    16. Flavio P Veras
    17. Lucas A Tavares
    18. Julia Forato
    19. Icaro MS Castro
    20. Lícia C Silva-Costa
    21. André C Palma
    22. Eli Mansour
    23. Raisa G Ulaf
    24. Ana F Bernardes
    25. Thyago A Nunes
    26. Luciana C Ribeiro
    27. Marcus V Agrela
    28. Maria Luiza Moretti
    29. Lucas I Buscaratti
    30. Fernanda Crunfli
    31. Raissa G Ludwig
    32. Jaqueline A Gerhardt
    33. Natália Munhoz-Alves
    34. Ana Maria Marques
    35. Renata Sesti-Costa
    36. Mariene R Amorim
    37. Daniel A Toledo-Teixeira
    38. Pierina Lorencini Parise
    39. Matheus Cavalheiro Martini
    40. Karina Bispos-dos-Santos
    41. Camila L Simeoni
    42. Fabiana Granja
    43. Virgínia C Silvestrini
    44. Eduardo B de Oliveira
    45. Vitor M Faca
    46. Murilo Carvalho
    47. Bianca G Castelucci
    48. Alexandre B Pereira
    49. Laís D Coimbra
    50. Marieli MG Dias
    51. Patricia B Rodrigues
    52. Arilson Bernardo SP Gomes
    53. Fabricio B Pereira
    54. Leonilda MB Santos
    55. Louis-Marie Bloyet
    56. Spencer Stumpf
    57. Marjorie C Pontelli
    58. Sean Whelan
    59. Andrei C Sposito
    60. Robson F Carvalho
    61. André S Vieira
    62. Marco AR Vinolo
    63. André Damasio
    64. Licio Velloso
    65. Ana Carolina M Figueira
    66. Luis LP da Silva
    67. Thiago Mattar Cunha
    68. Helder I Nakaya
    69. Henrique Marques-Souza
    70. Rafael E Marques
    71. Daniel Martins-de-Souza
    72. Munir S Skaf
    73. Jose Luiz Proenca-Modena
    74. Pedro MM Moraes-Vieira
    75. Marcelo A Mori
    76. Alessandro S Farias
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript by Brunetti et al. represents an important contribution where SARS-CoV-2 infection of T-helper cells is implicated and found to be mediated by CD4. The work progressed through a computationally driven hypothesis, by analyzing the interaction partners of SARS-CoV-2 spike glycoprotein (as initially modelled through similar SARS-CoV-1), followed by experimental validations, and further computational and experimental insights on the mechanism of binding. The study identifies the interaction between spike RBD domain and N Terminal domain of CD4 molecule as the specific viral attachment strategy. The evidence supporting the claims of the authors is solid, the results look significant and the data is clear and enough for understanding the manuscript. It also provides a potential usefulness of their approach in future work in understanding how viruses mediate infection of T cells. The work will be of interest to medical biologists working on SARS-CoV-2.

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  2. Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series

    This article has 16 authors:
    1. Ashkan Mowla
    2. Banafsheh Shakibajahromi
    3. Shima Shahjouei
    4. Afshin Borhani-Haghighi
    5. Nasrin Rahimian
    6. Humain Baharvahdat
    7. Soheil Naderi
    8. Fariborz Khorvash
    9. Davar Altafi
    10. Seyed Amir Ebrahimzadeh
    11. Ghasem Farahmand
    12. Alaleh Vaghefi Far
    13. Vijay K. Sharma
    14. Saeideh Aghayari Sheikh Neshin
    15. Georgios Tsivgoulis
    16. Ramin Zand

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. SARS-CoV-2 Seroprevalence in a Cohort of Asymptomatic RT-PCR Negative Croatian First League Football Players

    This article has 17 authors:
    1. Adriana Vince
    2. Renata Zadro
    3. Zvonimir Sostar
    4. Suncanica Ljubin Sternak
    5. Jasmina Vranes
    6. Vedrana Skaro
    7. Petar Projic
    8. Vilim Molnar
    9. Vid Matisic
    10. Bruno Barsic
    11. Gordan Lauc
    12. Zvjezdana Lovric-Makaric
    13. Zoran Bahtijarevic
    14. Tomislav Vlahovic
    15. Sandra Sikic
    16. Ozren Polasek
    17. Dragan Primorac

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  4. Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

    This article has 15 authors:
    1. Jennifer M. Sasson
    2. Joseph J. Campo
    3. Rebecca M. Carpenter
    4. Mary K. Young
    5. Arlo Z. Randall
    6. Krista Trappl-Kimmons
    7. Amit Oberai
    8. Christopher Hung
    9. Joshua Edgar
    10. Andy A. Teng
    11. Jozelyn V. Pablo
    12. Xiaowu Liang
    13. Angela Yee
    14. William A. Petri
    15. David Camerini

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  5. An olfactory self-test effectively screens for COVID-19

    This article has 29 authors:
    1. Kobi Snitz
    2. Danielle Honigstein
    3. Reut Weissgross
    4. Aharon Ravia
    5. Eva Mishor
    6. Ofer Perl
    7. Shiri Karagach
    8. Abebe Medhanie
    9. Nir Harel
    10. Sagit Shushan
    11. Yehudah Roth
    12. Behzad Iravani
    13. Artin Arshamian
    14. Gernot Ernst
    15. Masako Okamoto
    16. Cindy Poo
    17. Niccolò Bonacchi
    18. Zachary Mainen
    19. Erminio Monteleone
    20. Caterina Dinnella
    21. Sara Spinelli
    22. Franklin Mariño-Sánchez
    23. Camille Ferdenzi
    24. Monique Smeets
    25. Kazushige Touhara
    26. Moustafa Bensafi
    27. Thomas Hummel
    28. Johan N. Lundström
    29. Noam Sobel

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  6. A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics

    This article has 20 authors:
    1. Jonas Gossen
    2. Simone Albani
    3. Anton Hanke
    4. Benjamin P. Joseph
    5. Cathrine Bergh
    6. Maria Kuzikov
    7. Elisa Costanzi
    8. Candida Manelfi
    9. Paola Storici
    10. Philip Gribbon
    11. Andrea R. Beccari
    12. Carmine Talarico
    13. Francesca Spyrakis
    14. Erik Lindahl
    15. Andrea Zaliani
    16. Paolo Carloni
    17. Rebecca C. Wade
    18. Francesco Musiani
    19. Daria B. Kokh
    20. Giulia Rossetti

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