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  1. Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

    This article has 27 authors:
    1. Erik SchÀffner
    2. Mar Bosch-Queralt
    3. Julia M. Edgar
    4. Maria Lehning
    5. Judith Strauß
    6. Niko Fleischer
    7. Theresa Kungl
    8. Peter Wieghofer
    9. Stefan A. Berghoff
    10. Tilo Reinert
    11. Martin Krueger
    12. Markus Morawski
    13. Wiebke Möbius
    14. Alonso Barrantes-Freer
    15. Jens Stieler
    16. Ting Sun
    17. Gesine Saher
    18. Markus H. Schwab
    19. Christoph Wrede
    20. Maximilian Frosch
    21. Marco Prinz
    22. Daniel S. Reich
    23. Alexander FlĂŒgel
    24. Christine Stadelmann
    25. Robert Fledrich
    26. Klaus-Armin Nave
    27. Ruth M. Stassart
    This article has no evaluationsAppears in 1 listLatest version
  2. Cd59 and inflammation regulate Schwann cell development

    This article has 5 authors:
    1. Ashtyn T Wiltbank
    2. Emma R Steinson
    3. Stacey J Criswell
    4. Melanie Piller
    5. Sarah Kucenas
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper by Wiltbank et al. "Cd59 and inflammation orchestrate Schwann cell development" investigates the function of the small GPI-anchored protein Cd59, a protein known to suppress complement mediated inflammation, in Schwann cell development and myelination, using zebrafish as a model system. This paper will be of broad interest to developmental biologists, glial biologists and immunologists, as it suggests the interesting and novel findings that Cd59 regulates Schwann cell development, mainly by modulating Schwann cell proliferation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity
  3. Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

    This article has 33 authors:
    1. Anthony Fernåndez-Castañeda
    2. Peiwen Lu
    3. Anna C. Geraghty
    4. Eric Song
    5. Myoung-Hwa Lee
    6. Jamie Wood
    7. Belgin Yalçın
    8. Kathryn R. Taylor
    9. Selena Dutton
    10. Lehi Acosta-Alvarez
    11. Lijun Ni
    12. Daniel Contreras-Esquivel
    13. Jeff R. Gehlhausen
    14. Jon Klein
    15. Carolina Lucas
    16. Tianyang Mao
    17. Julio Silva
    18. Mario A. Peña-Hernåndez
    19. Alexandra Tabachnikova
    20. Takehiro Takahashi
    21. Laura Tabacof
    22. Jenna Tosto-Mancuso
    23. Erica Breyman
    24. Amy Kontorovich
    25. Dayna McCarthy
    26. Martha Quezado
    27. Marco Hefti
    28. Daniel Perl
    29. Rebecca Folkerth
    30. David Putrino
    31. Avi Nath
    32. Akiko Iwasaki
    33. Michelle Monje

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  4. Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

    This article has 13 authors:
    1. Vasiliki-Ilya Gargareta
    2. Josefine Reuschenbach
    3. Sophie B Siems
    4. Ting Sun
    5. Lars Piepkorn
    6. Carolina Mangana
    7. Erik SpÀte
    8. Sandra Goebbels
    9. Inge Huitinga
    10. Wiebke Möbius
    11. Klaus-Armin Nave
    12. Olaf Jahn
    13. Hauke B Werner
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      In this impressive manuscript the authors study the similarities and differences between the molecules that comprise the insulation that surrounds human brain nerve fibers (myelin), providing essential insight into how to interpret studies of myelin, from the perspective of different species. In all, this manuscript provides a new resource that will be of interest to the myelin community as well as investigators examining the contributions of oligodendrocytes to human neurodegenerative disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  5. A retroviral origin of vertebrate myelin

    This article has 14 authors:
    1. Tanay Ghosh
    2. Rafael G. Almeida
    3. Chao Zhao
    4. Abdelkrim Mannioui
    5. Elodie Martin
    6. Alex Fleet
    7. M Ginez Gonzalez
    8. David H Rowitch
    9. Katherine Stott
    10. Ian Adams
    11. Bernard Zalc
    12. Nick Goldman
    13. David A. Lyons
    14. Robin JM Franklin
    This article has no evaluationsAppears in 1 listLatest version
  6. Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

    This article has 23 authors:
    1. Constanze Depp
    2. Ting Sun
    3. Andrew Octavian Sasmita
    4. Lena Spieth
    5. Stefan A. Berghoff
    6. Agnes A. Steixner-Kumar
    7. Swati Subramanian
    8. Wiebke Möbius
    9. Sandra Göbbels
    10. Gesine Saher
    11. Silvia Zampar
    12. Oliver Wirths
    13. Maik Thalmann
    14. Takashi Saito
    15. Takaomi Saido
    16. Dilja Krueger-Burg
    17. Riki Kawaguchi
    18. Michael Willem
    19. Christian Haass
    20. Daniel Geschwind
    21. Hannelore Ehrenreich
    22. Ruth Stassart
    23. Klaus-Armin Nave

    Reviewed by preLights

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  7. Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination

    This article has 8 authors:
    1. Gustavo Della-Flora Nunes
    2. Emma R Wilson
    3. Edward Hurley
    4. Bin He
    5. Bert W O'Malley
    6. Yannick Poitelon
    7. Lawrence Wrabetz
    8. M Laura Feltri
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This manuscript builds upon the recent observation that Schwann cell (SC)-specific loss of the mitochondrial protein Prohibitin-1 results in a rapid, progressive demyelinating peripheral neuropathy in mice associated with mitochondrial dysfunction. They establish pathways as downstream effectors of mitochondrial dysfunction in Schwann cells. The authors provide a comprehensive evaluation of these pathways following the loss of Prophibitin-1 and identify JUN and mTORC1 as potential mediators of myelin disruption.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity