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A list by Dr. Reeteka Sud

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5 articlesLast updated

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  3. NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

    1. Theresa Pohlkamp
    2. Xunde Xian
    3. Connie H Wong
    4. Murat S Durakoglugil
    5. Gordon Chandler Werthmann
    6. Takaomi C Saido
    7. Bret M Evers
    8. Charles L White
    9. Jade Connor
    10. Robert E Hammer
    11. Joachim Herz

    • Curated by eLife

      Evaluation Summary:

      This paper is of interest to a broad range of neuroscientists, particularly those interested in ApoE biology and Alzheimer's disease (AD), as it reveals a novel mechanism that counteracts AD-linked amyloid plaque burden and synapse dysfunction in mice. Overall, the methodology is sound, sophisticated, and employs animal models that more closely mimic human diseases, and the results are interesting and compelling. Whilst the mechanistic hypothesis proposed by the authors is consistent with the data, plausible alternative explanations remain.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  4. Early and lifelong effects of APOE4 on neuronal gene expression networks relevant to Alzheimer’s disease

    1. Brian P. Grone
    2. Kelly A. Zalocusky
    3. Yanxia Hao
    4. Seo Yeon Yoon
    5. Patrick Arriola
    6. Yadong Huang

    • Curated by eLife

      Evaluation Summary:

      This manuscript is of broad interest to readers in the field of Alzheimer's disease, neurodegeneration, and single-cell omics. The identification of shared pathways across different cell types and ages is an important contribution to our understanding of APOE4 gene regulation in a cell type-specific manner. A combination of snRNAseq in APOE mouse models and human iPSC cells supports the key claims in the paper.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  5. Differentiation signals from glia are fine-tuned to set neuronal numbers during development

    1. Anadika R Prasad
    2. Inês Lago-Baldaia
    3. Matthew P Bostock
    4. Zaynab Housseini
    5. Vilaiwan M Fernandes

    • Curated by eLife

      Evaluation Summary:

      This manuscript will be of interest to cell and developmental biologists and neuroscientists. It addresses the question of how the number of connecting neurons in a circuit is matched whilst maintaining topography. It shows that non-autonomous control of neuronal number involves a relay mechanism through two distinct glial cell types, enabling the specification of distinct neuronal classes.

      This manuscript was co-submitted with: https://www.biorxiv.org/content/10.1101/2022.02.21.481306v1

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity