Preprint highlights for June

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Using macromolecular electron densities to improve the enrichment of active compounds in virtual screening

This article has 12 authors:
1. Wenzhi Ma
2. Wei Zhang
3. Yuan Le
4. Xiaoxuan Shi
5. Qingbo Xu
6. Yang Xiao
7. Yueying Dou
8. Xiaoman Wang
9. Wenbiao Zhou
10. Wei Peng
11. Hongbo Zhang
12. Bo Huang
Reviewed by PREreview

This article has 1 evaluationAppears in 2 listsLatest version Apr 4, 2023Latest activity Jun 6, 2023
A Multiscale Protein Abundance Structured Population Kinetic Model Systematically Explores the Design Space of Constitutive and Inducible CAR-T cells

This article has 3 authors:
1. Harshana Rajakaruna
2. Milie Desai
3. Jayajit Das
Reviewed by Review Commons

This article has 3 evaluationsAppears in 2 listsLatest version Jan 9, 2023Latest activity Apr 20, 2023
marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis

This article has 8 authors:
1. AP Francisco
2. I Tastekin
3. AB Fernandes
4. G Ezra-Nevo
5. B Deplancke
6. AJ Oliveira-Maia
7. AM Gontijo
8. C Ribeiro
Reviewed by preLights

This article has 1 evaluationAppears in 2 listsLatest version Dec 19, 2022Latest activity Mar 22, 2023
Rapid and sensitive detection of native glycoRNAs

This article has 6 authors:
1. Helena Hemberger
2. Peiyuan Chai
3. Charlotta G. Lebedenko
4. Reese M. Caldwell
5. Benson M. George
6. Ryan A. Flynn
Reviewed by Arcadia Science

This article has 10 evaluationsAppears in 2 listsLatest version Feb 26, 2023Latest activity May 16, 2023
Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

This article has 6 authors:
1. Heidi M. Blank
2. Carsten Reuse
3. Kerstin Schmidt-Hohagen
4. Staci E. Hammer
5. Karsten Hiller
6. Michael Polymenis
Reviewed by Review Commons

This article has 4 evaluationsAppears in 2 listsLatest version Apr 30, 2023Latest activity Apr 21, 2023
Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

This article has 16 authors:
1. Karthickeyan Chella Krishnan
2. Elie-Julien El Hachem
3. Luke Carroll
4. Alexis Diaz Vegas
5. Christine Light
6. Yang Cao
7. Calvin Pan
8. Karolina Elżbieta Kaczor-Urbanowicz
9. Varun Shravah
10. Diana Anum
11. Matteo Pellegrini
12. Chi Fung Lee
13. Marcus M. Seldin
14. Benjamin L. Parker
15. David E. James
16. Aldons J. Lusis
This article has been curated by 1 group:
- Curated by eLife
  
  eLife assessment
  
  This paper demonstrates the genetic architecture of heart mitochondrial proteome that influences cardiac hypertrophy, using a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). The HDM panel is a very powerful tool to study the genetic basis of various physiological and pathological processes in mice. The authors have used this panel extensively before, and in this paper, they extend their proteomic studies to demonstrate the genetic basis of cardiac hypertrophy. The studies will allow us to better understand the genetics of hypertrophic cardiomyopathy.
Reviewed by eLife

This article has 4 evaluationsAppears in 3 listsLatest version Aug 26, 2022Latest activity Apr 15, 2023
HSV-1 exploits host heterochromatin for egress

This article has 7 authors:
1. Hannah C Lewis
2. Laurel E Kelnhofer-Millevolte
3. Mia R Brinkley
4. Hannah E Arbach
5. Edward A Arnold
6. Srinivas Ramachandran
7. Daphne C Avgousti
Reviewed by Review Commons

This article has 4 evaluationsAppears in 2 listsLatest version Aug 15, 2022Latest activity Apr 28, 2023
SARS-CoV-2 Spike Protein Reduces Burst Activities in Neurons Measured by Micro-Electrode Arrays

This article has 13 authors:
1. Melanie Salvador
2. Noah Tseng
3. Camdon Park
4. Grace Williams
5. Arianne Vethan
6. Grant Thomas
7. John Baker
8. Joseph Hemry
9. Emma Hammond
10. Paige Freeburg
11. Guan-Wen Chou
12. Nick Taylor
13. Yi-Fan Lu
Reviewed by PREreview

This article has 1 evaluationAppears in 2 listsLatest version Apr 25, 2023Latest activity Apr 26, 2023
Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

This article has 7 authors:
1. Milena Rmus
2. Mingjian He
3. Beth Baribault
4. Edward G. Walsh
5. Elena K. Festa
6. Anne G.E. Collins
7. Matthew R. Nassar
This article has been curated by 1 group:
- Curated by eLife
  
  eLife assessment
  
  This important study combines behavior, computational modelling and magnetic resonance spectroscopy to address the question whether age-related declines in learning are driven by declines in working memory or deficiencies of the RL system. The general approach is solid, but the presented evidence to support the papers' main claims could be stronger. With additional analyses and adaptation of the main claims, the paper could be of high interest for researchers in the field of cognitive aging and decision making.
Reviewed by eLife

This article has 5 evaluationsAppears in 3 listsLatest version Apr 10, 2023Latest activity Apr 16, 2023
ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

This article has 12 authors:
1. Aleksandar Bartolome
2. Julia C. Heiby
3. Domenico Di Fraia
4. Ivonne Heinze
5. Hannah Knaudt
6. Ellen Spaeth
7. Omid Omrani
8. Alberto Minetti
9. Maleen Hofmann
10. Joanna M. Kirkpatrick
11. Therese Dau
12. Alessandro Ori
Reviewed by preLights

This article has 1 evaluationAppears in 2 listsLatest version Sep 30, 2023Latest activity May 1, 2023
Interplay between PLEKHG3-regulated actin dynamics and lysosomal trafficking in cell motility

This article has 8 authors:
1. Rainer Ettelt
2. Georg Vucak
3. Sebastian Didusch
4. Biljana Riemelmoser
5. Karin Ehrenreiter
6. Markus Hartl
7. Lukas A. Huber
8. Manuela Baccarini
Reviewed by Review Commons

This article has 4 evaluationsAppears in 2 listsLatest version May 4, 2023Latest activity May 5, 2023
A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

This article has 15 authors:
1. Brett Volmert
2. Ashlin Riggs
3. Fei Wang
4. Aniwat Juhong
5. Artem Kiselev
6. Aleksandra Kostina
7. Colin O’Hern
8. Priyadharshni Muniyandi
9. Aaron Wasserman
10. Amanda Huang
11. Yonatan Lewis-Israeli
12. Sangbum Park
13. Zhen Qiu
14. Chao Zhou
15. Aitor Aguirre
Reviewed by preLights

This article has 1 evaluationAppears in 2 listsLatest version Dec 20, 2022Latest activity Feb 13, 2023
Metabolic rewiring of mitochondria in senescence revealed by time-resolved analysis of the mitochondrial proteome

This article has 5 authors:
1. Jun Yong Kim
2. Ilian Atanassov
3. Frederik Dethloff
4. Lara Kroczek
5. Thomas Langer
Reviewed by Review Commons

This article has 4 evaluationsAppears in 2 listsLatest version Oct 14, 2022Latest activity May 2, 2023
Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

This article has 22 authors:
1. Mei Hong Liu
2. Benjamin Costa
3. Una Choi
4. Rachel C. Bandler
5. Emilie Lassen
6. Marta Grońska-Pęski
7. Adam Schwing
8. Zachary R. Murphy
9. Daniel Rosenkjær
10. Shany Picciotto
11. Vanessa Bianchi
12. Lucie Stengs
13. Melissa Edwards
14. Caitlin A. Loh
15. Tina K. Truong
16. Randall E. Brand
17. Tomi Pastinen
18. J. Richard Wagner
19. Anne-Bine Skytte
20. Uri Tabori
21. Jonathan E. Shoag
22. Gilad D. Evrony
Reviewed by preLights

This article has 1 evaluationAppears in 2 listsLatest version Feb 19, 2023Latest activity Feb 28, 2023

Preprint highlights for June

Using macromolecular electron densities to improve the enrichment of active compounds in virtual screening

A Multiscale Protein Abundance Structured Population Kinetic Model Systematically Explores the Design Space of Constitutive and Inducible CAR-T cells

marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis

Rapid and sensitive detection of native glycoRNAs

Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

Curated by eLife

HSV-1 exploits host heterochromatin for egress

SARS-CoV-2 Spike Protein Reduces Burst Activities in Neurons Measured by Micro-Electrode Arrays

Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

Curated by eLife

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

Interplay between PLEKHG3-regulated actin dynamics and lysosomal trafficking in cell motility

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

Metabolic rewiring of mitochondria in senescence revealed by time-resolved analysis of the mitochondrial proteome

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing