Preprint highlights for June

A list by Sciety

A collection of the evaluated preprints we've been highlighting on social media.

14 articlesLast updated

Related articles (Labs 🧪)

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  6. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

    1. Karthickeyan Chella Krishnan
    2. Elie-Julien El Hachem
    3. Mark P Keller
    4. Sanjeet G Patel
    5. Luke Carroll
    6. Alexis Diaz Vegas
    7. Isabela Gerdes Gyuricza
    8. Christine Light
    9. Yang Cao
    10. Calvin Pan
    11. Karolina Elżbieta Kaczor-Urbanowicz
    12. Varun Shravah
    13. Diana Anum
    14. Matteo Pellegrini
    15. Chi Fung Lee
    16. Marcus M Seldin
    17. Nadia A Rosenthal
    18. Gary A Churchill
    19. Alan D Attie
    20. Benjamin Parker
    21. David E James
    22. Aldons J Lusis

    • Curated by eLife

      eLife assessment

      This paper demonstrates the genetic architecture of heart mitochondrial proteome that influences cardiac hypertrophy, using a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). The HDM panel is a very powerful tool to study the genetic basis of various physiological and pathological processes in mice. The authors have used this panel extensively before, and in this paper, they extend their proteomic studies to demonstrate the genetic basis of cardiac hypertrophy. The studies will allow us to better understand the genetics of hypertrophic cardiomyopathy.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  7. HSV-1 exploits host heterochromatin for egress

    1. Hannah C Lewis
    2. Laurel E Kelnhofer-Millevolte
    3. Mia R Brinkley
    4. Hannah E Arbach
    5. Edward A Arnold
    6. Srinivas Ramachandran
    7. Daphne C Avgousti

    Reviewed by Review Commons

    4 evaluationsAppears in 2 listsLatest version Latest activity

  9. Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    1. Milena Rmus
    2. Mingjian He
    3. Beth Baribault
    4. Edward G Walsh
    5. Elena K Festa
    6. Anne GE Collins
    7. Matthew R Nassar

    • Curated by eLife

      eLife assessment

      This important study combines behavior, computational modelling and magnetic resonance spectroscopy to address the question whether age-related declines in learning are driven by declines in working memory or deficiencies of the RL system. The general approach is solid, but the presented evidence to support the papers' main claims could be stronger. With additional analyses and adaptation of the main claims, the paper could be of high interest for researchers in the field of cognitive aging and decision making.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  10. Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

    1. Aleksandar Bartolome
    2. Julia C Heiby
    3. Domenico Di Fraia
    4. Ivonne Heinze
    5. Hannah Knaudt
    6. Ellen Spaeth
    7. Omid Omrani
    8. Alberto Minetti
    9. Maleen Hofmann
    10. Joanna M Kirkpatrick
    11. Therese Dau
    12. Alessandro Ori

    • Curated by eLife

      eLife assessment

      This study presents an important method and resource in cell lines and in mice for mass spectrometry-based identification of interactors of the proteasome, a multi-protein complex with a central role in protein turnover in almost all tissues and cell types. The method presented, including the experimental workflow and analysis pipeline, as well as the several lines of validation provided throughout, is convincing. Given the growing interest in protein aggregation and targeted protein degradation modalities, this work will be of interest to a broad spectrum of basic cell biologists and translational researchers.

    Reviewed by eLife, preLights

    9 evaluationsAppears in 3 listsLatest version Latest activity

  14. Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

    1. Mei Hong Liu
    2. Benjamin Costa
    3. Una Choi
    4. Rachel C. Bandler
    5. Emilie Lassen
    6. Marta Grońska-Pęski
    7. Adam Schwing
    8. Zachary R. Murphy
    9. Daniel Rosenkjær
    10. Shany Picciotto
    11. Vanessa Bianchi
    12. Lucie Stengs
    13. Melissa Edwards
    14. Caitlin A. Loh
    15. Tina K. Truong
    16. Randall E. Brand
    17. Tomi Pastinen
    18. J. Richard Wagner
    19. Anne-Bine Skytte
    20. Uri Tabori
    21. Jonathan E. Shoag
    22. Gilad D. Evrony

    Reviewed by preLights

    1 evaluationAppears in 2 listsLatest version Latest activity