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  1. Genetic Architecture of Heart Mitochondrial Proteome influencing Cardiac Hypertrophy

    This article has 16 authors:
    1. Karthickeyan Chella Krishnan
    2. Elie-Julien El Hachem
    3. Luke Carroll
    4. Alexis Diaz Vegas
    5. Christine Light
    6. Yang Cao
    7. Calvin Pan
    8. Karolina Elżbieta Kaczor-Urbanowicz
    9. Varun Shravah
    10. Diana Anum
    11. Matteo Pellegrini
    12. Chi Fung Lee
    13. Marcus M. Seldin
    14. Benjamin L. Parker
    15. David E. James
    16. Aldons J. Lusis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper demonstrates the genetic architecture of heart mitochondrial proteome that influences cardiac hypertrophy, using a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). The HDM panel is a very powerful tool to study the genetic basis of various physiological and pathological processes in mice. The authors have used this panel extensively before, and in this paper, they extend their proteomic studies to demonstrate the genetic basis of cardiac hypertrophy. The studies will allow us to better understand the genetics of hypertrophic cardiomyopathy.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 3 listsLatest version Latest activity
  2. HSV-1 exploits host heterochromatin for egress

    This article has 7 authors:
    1. Hannah C Lewis
    2. Laurel E Kelnhofer-Millevolte
    3. Mia R Brinkley
    4. Hannah E Arbach
    5. Edward A Arnold
    6. Srinivas Ramachandran
    7. Daphne C Avgousti

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  3. Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    This article has 7 authors:
    1. Milena Rmus
    2. Mingjian He
    3. Beth Baribault
    4. Edward G. Walsh
    5. Elena K. Festa
    6. Anne G.E. Collins
    7. Matthew R. Nassar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study combines behavior, computational modelling and magnetic resonance spectroscopy to address the question whether age-related declines in learning are driven by declines in working memory or deficiencies of the RL system. The general approach is solid, but the presented evidence to support the papers' main claims could be stronger. With additional analyses and adaptation of the main claims, the paper could be of high interest for researchers in the field of cognitive aging and decision making.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 3 listsLatest version Latest activity
  4. Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

    This article has 22 authors:
    1. Mei Hong Liu
    2. Benjamin Costa
    3. Una Choi
    4. Rachel C. Bandler
    5. Emilie Lassen
    6. Marta Grońska-Pęski
    7. Adam Schwing
    8. Zachary R. Murphy
    9. Daniel Rosenkjær
    10. Shany Picciotto
    11. Vanessa Bianchi
    12. Lucie Stengs
    13. Melissa Edwards
    14. Caitlin A. Loh
    15. Tina K. Truong
    16. Randall E. Brand
    17. Tomi Pastinen
    18. J. Richard Wagner
    19. Anne-Bine Skytte
    20. Uri Tabori
    21. Jonathan E. Shoag
    22. Gilad D. Evrony

    Reviewed by preLights

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity