Evaluated articles

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

1. Aleksandra Białas
2. Thorsten Langner
3. Adeline Harant
4. Mauricio P Contreras
5. Clare EM Stevenson
6. David M Lawson
7. Jan Sklenar
8. Ronny Kellner
9. Matthew J Moscou
10. Ryohei Terauchi
11. Mark J Banfield
12. Sophien Kamoun

• Curated by eLife

  Evaluation Summary:

  Convergent evolution is often observed in nature, but the molecular mechanisms allowing similar functions to independently emerge are rarely understood. This work determines how the high-affinity recognition of a pathogenic effector produced by the rice blast fungus, Avr-PikD, evolved in the immune receptor Pik-1. The integration of molecular evolution analyses with structure-function biochemical testing is novel to the field and the data quality is exceptional. In addition to advancing knowledge of host-microbe co-evolution, this work is exemplary in its transparency and the breadth of approaches utilized to understand protein evolution, and we expect that this study will provide a conceptual framework for similar studies in the future.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, PREreview

Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation

1. Ethan Ford
2. Matthew R. Grimmer
3. Sabine Stolzenburg
4. Ozren Bogdanovic
5. Alex de Mendoza
6. Peggy J. Farnham
7. Pilar Blancafort
8. Ryan Lister

Reviewed by PREreview

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

1. Tao Zeng
2. Yongqing Cao
3. Jianmei Yin
4. Peishi Feng
5. Yong Tian
6. Hanxue Sun
7. Tiantian Gu
8. Yibo Zong
9. Xueying Ma
10. Zelong Zhao
11. Li Chen
12. Wenwu Xu
13. Wei Han
14. Lizhi Lu

Reviewed by PREreview

Unraveling the genetic legacy of commercial whaling in bowhead whales and narwhals

1. Evelien de Greef
2. Claudio Müller
3. Matt J. Thorstensen
4. Steven H. Ferguson
5. Cortney A. Watt
6. Marianne Marcoux
7. Stephen D. Petersen
8. Colin J. Garroway

Reviewed by PREreview

Genetic architecture of inbreeding depression may explain its persistence in a population of wild red deer

1. Anna M. Hewett
2. Susan E. Johnston
3. Alison Morris
4. Sean Morris
5. Josephine M. Pemberton

Reviewed by PREreview

On the independent irritability of goldfish eggs and embryos – a living communication on the rhythmic yolk contractions in goldfish

1. Paul Gerald Layague Sanchez
2. Chen-Yi Wang
3. Ing-Jia Li
4. Kinya G. Ota

Reviewed by PREreview

CYpHER: catalytic extracellular targeted protein degradation with high potency and durable effect

1. Zachary R. Crook
2. Gregory P. Sevilla
3. Pamela Young
4. Emily J. Girard
5. Tinh-Doan Phi
6. Monique L. Howard
7. Jason Price
8. James M. Olson
9. Natalie W. Nairn

Reviewed by PREreview

Temperate freshwater soundscapes: A cacophony of undescribed biological sounds now threatened by anthropogenic noise

1. Rodney A. Rountree
2. Francis Juanes
3. Marta Bolgan

Reviewed by PREreview

Chronic Broadband Noise Increases the Fitness of a Laboratory-Raised Freshwater Zooplankton

1. Loïc Prosnier
2. Emilie Rojas
3. Olivier Valéro
4. Vincent Médoc

Reviewed by PREreview

Dissecting translation elongation dynamics through ultra-long tracking of single ribosomes

1. Maximilian F. Madern
2. Sora Yang
3. Olivier Witteveen
4. Marianne Bauer
5. Marvin E. Tanenbaum

Reviewed by PREreview

Heterogeneous folding landscapes and predetermined breaking points within a protein family

1. Sebastian Pechmann

Reviewed by PREreview

Water Footprint Reduction in Oil and Gas Refineries through Water Reuse: A Systematic Review

1. Fallah Hashemi
2. Stephanie Young
3. Hassan Hashemi
4. Tiina Leiviskä
5. Leila Shafea
6. Marjan Hajivand
7. Babak Borj

Reviewed by PREreview

Highly multiplexed design of an allosteric transcription factor to sense novel ligands

1. Kyle K. Nishikawa
2. Jackie Chen
3. Justin F. Acheson
4. Svetlana V. Harbaugh
5. Phil Huss
6. Max Frenkel
7. Nathan Novy
8. Hailey R. Sieren
9. Ella C. Lodewyk
10. Daniel H. Lee
11. Jorge L. Chávez
12. Brian G. Fox
13. Srivatsan Raman

Reviewed by PREreview

Teste de Significância de Hipótese Nula na Análise do Comportamento: Problemas e recomendações

1. Bruna Rodrigues Lins
2. Bruno Strapasson

Reviewed by PREreview

Gaps between Open Science activities and actual recognition systems: Insights from an international survey

1. Florencia Grattarola
2. Hanna Shmagun
3. Christopher Erdmann
4. Anne Cambon-Thomsen
5. Mogens Thomsen
6. Jaesoo Kim
7. Laurence Mabile

Reviewed by PREreview

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex

1. Caleb R. Carr
2. Katharine H.D. Crawford
3. Michael Murphy
4. Jared G. Galloway
5. Hugh K. Haddox
6. Frederick A. Matsen
7. Kristian G. Andersen
8. Neil P. King
9. Jesse D. Bloom

Reviewed by PREreview

A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation

1. Wenjia Yu
2. Meng Li
3. Wenjun Wang
4. Haiyan Zhuang
5. Jiamin Luo
6. Yuying Sang
7. Cecile Segonzac
8. Alberto P. Macho

Reviewed by PREreview

Targeting protein-ligand neosurfaces using a generalizable deep learning approach

1. Anthony Marchand
2. Stephen Buckley
3. Arne Schneuing
4. Martin Pacesa
5. Pablo Gainza
6. Evgenia Elizarova
7. Rebecca M. Neeser
8. Pao-Wan Lee
9. Luc Reymond
10. Maddalena Elia
11. Leo Scheller
12. Sandrine Georgeon
13. Joseph Schmidt
14. Philippe Schwaller
15. Sebastian J. Maerkl
16. Michael Bronstein
17. Bruno E. Correia

Reviewed by PREreview

Active mechanics of sea star oocytes

1. Peter J. Foster
2. Sebastian Fürthauer
3. Nikta Fakhri

Reviewed by PREreview