Vitamin D is a biomarker of clinical disease severity in oral lichen planus
This article has been Reviewed by the following groups
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
- Evaluated articles (PREreview)
Abstract
Oral lichen planus (OLP) is a chronic inflammatory condition known to adversely impact patient quality of life and is associated with an increased risk of cancer. The diverse clinical presentation and poor knowledge of clinical factors that determine the course of disease are amongst the main challenges that hinder effective and personalised treatment for OLP patients.
This study aimed to systematically identify clinical predictors of disease severity in OLP patients. A cohort of patients with histologically confirmed OLP (n=89) was recruited in a cross-sectional and single site study. A comprehensive assessment of clinical characteristics, medical and social history, haematological parameters, vitamin D levels, and Perceived Stress Scale (PSS-10) was carried out. Hierarchical linear regression identified the predictive value of clinical factors to OLP disease severity measured by the Oral Disease Severity Score (ODSS) and the Reticular/hyperkeratotic, Erosive/erythematous, Ulcerative (REU) scoring system.
Findings revealed that extraoral lichen planus and insufficient vitamin D levels were significant predictors of both overall and gingival disease severity of OLP. Specifically, patients with lichen planus affecting the skin or other mucosal sites had a 5.766-unit higher OLP severity score (β=5.766, 95% CI=.744-10.788, p=.025) than those without extraoral involvement as measured by ODSS. Patients with insufficient vitamin D levels exhibited 5.490-unit increase in OLP severity (β=5.490, 95% CI=1.136-9.844, p=.014) compared to those with adequate vitamin D levels. The presence of dental plaque-induced gingivitis (β=4.833, 95% CI=.974-8.692, p=.015), was found to be a significant factor affecting gingival disease severity.
This study revealed the importance of adequate vitamin D levels in OLP patients and suggests embedding vitamin D pre-treatment screening to optimise management of OLP. Future research should focus on elucidating the biological mechanisms underlying the protective effects of vitamin D in OLP.
Article activity feed
-
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17464740.
In this paper, the authors recruited a cohort of patients (n=89) with historically confirmed oral lichen planus in a cross-sectional and single site study, while carrying out a comprehensive assessment of clinical characteristics, medical and social history, haematological parameters, vitamin D levels and "Perceived Stress Scale (PSS-10)".
The preprint contains approximately 14 pages of text and three tables.
Introduction:
The title, specifically the use of the word "biomarker" may be misleading, as readers may expect a biochemical approach to the study. Furthermore, the use of the term "biomarker" isn't exactly correct for the role of vitamin D in oral lichen planus, given by its definitio
In…
This Zenodo record is a permanently preserved version of a PREreview. You can view the complete PREreview at https://prereview.org/reviews/17464740.
In this paper, the authors recruited a cohort of patients (n=89) with historically confirmed oral lichen planus in a cross-sectional and single site study, while carrying out a comprehensive assessment of clinical characteristics, medical and social history, haematological parameters, vitamin D levels and "Perceived Stress Scale (PSS-10)".
The preprint contains approximately 14 pages of text and three tables.
Introduction:
The title, specifically the use of the word "biomarker" may be misleading, as readers may expect a biochemical approach to the study. Furthermore, the use of the term "biomarker" isn't exactly correct for the role of vitamin D in oral lichen planus, given by its definitio
In general, the introduction offers a brief overview on the current state of research regarding oral lichen planus, "OLP" for short, as well as its global prevalence.
There are no images for reference provided, which might have been helpful for readers who are not familiar with oral lichen planus, especially since OLP presents with "the most common clinical presentation", as stated. In addition, images to present the different severities in oral lichen planus with and without vitamin D deficiency would have contributed to a better understanding of the relevancy of the study.
Dental/medical terms could have been explained further for readers not familiar with this field
Materials and Methods:
It is stated that the cross-sectional study was fully compliant with "STROBE" guidelines. Please give a brief definition on what exactly those guidelines include.
Which statistical text method was used?
How reliable are the patient's answers on the questionnaire for the PSS-10? Since perceived stress is oftentimes subjective, we worry about the comparability of the data.
Which local reference ranges were used? If this is supposed to be the control group, who was in it? Is there data on their medical history or any of the other relevant factors to this study provided?
Patients under systemic steroid and immunosuppressive therapy were excluded, a notice on other patients who were under any other medication is needed. A nutrition protocol to detect the patients eating habits may have been useful too, as specific foods and drinks can contribute to inflammation in the oral mucosa, effecting already existing OLP.
It is written what the abbreviations ODSS and REU stand for, but not further explained what the scoring systems include, what are they based on?
Results:
Display of most relevant results may be improved through a more visual choice of display in the form of a diagram for example.
Competing interests
The authors declare that they have no competing interests.
Use of Artificial Intelligence (AI)
The authors declare that they did not use generative AI to come up with new ideas for their review.
-
