Evaluated articles

Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy

1. Mathieu Rouanne
2. Noah Chen
3. Dylan L. Mariuzza
4. Fangda Li
5. Kenia de los Santos-Alexis
6. Thomas M. Savage
7. Rosa L. Vincent
8. Cathy L. Mendelsohn
9. Tal Danino
10. Nicholas Arpaia

Reviewed by PREreview

“Does it feel like a scientific paper?”: A qualitative analysis of preprint servers’ moderation and quality assurance processes

1. Natascha Chtena
2. Irene Pasquetto
3. Alice Fleerackers
4. Stephen Pinfield
5. Melanie Benson Marshall
6. Juan Pablo Alperin

Reviewed by PREreview

TYK2 as a novel therapeutic target in Alzheimer’s Disease with TDP-43 inclusions

1. Laura E. König
2. Steve Rodriguez
3. Clemens Hug
4. Shayda Daneshvari
5. Alexander Chung
6. Gary A. Bradshaw
7. Asli Sahin
8. George Zhou
9. Robyn J. Eisert
10. Federica Piccioni
11. Sudeshna Das
12. Marian Kalocsay
13. Artem Sokolov
14. Peter Sorger
15. David E. Root
16. Mark W. Albers

Reviewed by PREreview

Determining accurate conformational ensembles of intrinsically disordered proteins at atomic resolution

1. Kaushik Borthakur
2. Thomas R. Sisk
3. Francesco P. Panei
4. Massimiliano Bonomi
5. Paul Robustelli

Reviewed by PREreview

Identification of Potential Hub Genes and Therapeutic Targets in Colorectal Cancer Using Integrated Bioinformatics Approaches

1. Kamalakannan D
2. Manivannan R
3. Suresh Gopal Kumar
4. Dilip Kumar

Reviewed by PREreview

Bilingualism Modulates Executive Function Development in Pre-School Aged Children: A Preliminary Study

1. Sally Sade
2. Scott Rathwell
3. Bryan Kolb
4. Claudia Gonzalez
5. Robbin Gibb

Reviewed by PREreview

Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

1. Aly Elezaby
2. Ryan Dexheimer
3. David Wu
4. Sze Yu Chan
5. Ines Ross Tacco
6. Ian Y. Chen
7. Nazish Sayed
8. Karim Sallam

Reviewed by PREreview

Fluorescent Antibody-Based Detection and Ultrastructural Analysis of Streptococcus pneumoniae in Human Sputum

1. Ana G. Jop Vidal
2. Meg Francis
3. Maneesha Chitanvis
4. Ithiel J. Frame
5. Poonam Sharma
6. Patricio Vidal
7. Claudio F. Lanata
8. Carlos Grijalva
9. William Daley
10. Jorge E. Vidal

Reviewed by PREreview

Stress from Cadaver Dissection Linked to Learning Conditions: Evidence from Sub-Saharan Africa

1. Jude Amechi Nnaka
2. Victor Udochukwu Ezeike
3. Kristjan Thompson
4. Izuchukwu Azuka Okafor

Reviewed by PREreview

Safety and efficacy of the blood-stage malaria vaccine RH5.1/Matrix-M in Burkina Faso: interim results of a double-blind, randomised, controlled, phase 2b trial in children

1. Hamtandi M Natama
2. Jo Salkeld
3. Athanase Somé
4. Seyi Soremekun
5. Salou Diallo
6. Ousmane Traoré
7. Toussaint Rouamba
8. Florence Ouédraogo
9. Edouard Ouédraogo
10. K Carine Sonia Daboné
11. Nadine A Koné
12. Z Michael John Compaoré
13. Miguel Kafando
14. Massa dit Achille Bonko
15. Fabé Konaté
16. Hermann Sorgho
17. Carolyn M Nielsen
18. Dimitra Pipini
19. Ababacar Diouf
20. Lloyd D W King
21. Umesh Shaligram
22. Carole A Long
23. Jee-Sun Cho
24. Alison M Lawrie
25. Katherine Skinner
26. Rachel Roberts
27. Kazutoyo Miura
28. John Bradley
29. Sarah E Silk
30. Simon J Draper
31. Halidou Tinto
32. Angela M Minassian

Reviewed by PREreview

Prior antiretroviral therapy exposure among clients presenting for HIV treatment initiation in South Africa: an exploratory mixed-methods study using multiple indicators of exposure

1. Mariet Benade
2. Mhairi Maskew
3. Vinolia Ntjikelane
4. Nancy Scott
5. Nkosinathi Ngcobo
6. Brooke Nichols
7. Lufuno Malala
8. Musa Manganye
9. Sydney Rosen

Reviewed by PREreview

Toxoplasma Infection and Its Sequential Impact on Physical Health, Stress, and Anxiety: A Large Cross-Sectional Study Testing the Stress-Coping Hypothesis

1. Jaroslav Flegr
2. Ashkan Latifi
3. Šárka Kaňková

Reviewed by PREreview

IMPACTO SOCIAL DE LAS BARRERAS EN EL PROCESO DE CERTIFICACIÓN DE DISCAPACIDAD EN COLOMBIA

1. Lina María González Ballesteros
2. Camila Andrea Castellanos Roncancio
3. Jeimmi Paola Carvajal Guzmán

Reviewed by PREreview

O ensino de Ciências no Brasil: Um olhar voltado à Educação Infantil e Séries Iniciais

1. Marluce da Cunha Mantovani
2. Leandro Teodoro Júnior
3. Mari Cleide Sogayar

Reviewed by PREreview

Evaluación formativa: percepciones de los estudiantes de educación superior respecto a las habilidades/estrategias de aprendizaje autodirigido

1. Concepcion Elizabeth Marcillo-Garcia
2. Elvira Geoconda Villacreses-Veliz
3. Mercedes del Rosario Acuña-Acebo
4. Jessenia Herminia Morán-Chilán

Reviewed by PREreview

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

1. Jonathan G Van Vranken
2. Jiaming Li
3. Julian Mintseris
4. Ting-Yu Wei
5. Catherine M Sniezek
6. Meagan Gadzuk-Shea
7. Steven P Gygi
8. Devin K Schweppe

• Curated by eLife

  eLife Assessment

  The study provides a valuable showcase of a workflow to perform large-scale characterization of drug mechanisms of action using proteomics in which on-target and off-targets of 166 compounds using proteome solubility analysis in living cells and cell lysates were determined. The evidence supporting the claims of the authors is solid, however, the inclusion of more replicate experiments and more statistical rigor would have strengthened the study. This will be of broad interest to medicinal chemists, toxicologists, computational biologists and biochemists.

Reviewed by PREreview, eLife

Evaluating the accuracy and reliability of large language models in assisting with pediatric differential diagnoses: A multicenter diagnostic study

1. Masab A. Mansoor
2. Andrew F. Ibrahim
3. David J. Grindem
4. Asad Baig

Reviewed by PREreview

Benzoxazinoid-mediated microbiome feedbacks enhance Arabidopsis growth and defence

1. Katja Stengele
2. Lea Stauber
3. Lisa Thoenen
4. Henry Janse van Rensburg
5. Viola D’Adda
6. Klaus Schlaeppi

Reviewed by PREreview

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

1. Anna Shemorry
2. Willem den Besten
3. Melinda M. Mulvihill
4. Curt J. Essenburg
5. Nicole Blaquiere
6. Tracy Kleinheinz
7. Elisia Villemure
8. Frank Peale
9. Gauri Deshmukh
10. Danilo Maddalo
11. Elizabeth Levy
12. Kebing Yu
13. Matthew R. Steensma
14. Elizabeth A. Tovar
15. Emily Wolfrum
16. Karthik Nagapudi
17. Robert A. Blake
18. William F. Forrest
19. Steven T. Staben
20. Carrie R. Graveel
21. Wayne J. Fairbrother
22. Ingrid E. Wertz

Reviewed by PREreview

Modular small RNA drives the emergence of virulence traits and environmental trade-offs in Vibrio cholerae

1. Deepak Balasubramanian
2. Cole Crist
3. Salvador Almagro-Moreno

Reviewed by PREreview