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  1. Artificial Intelligence in Healthcare: 2023 Year in Review

    This article has 12 authors:
    1. Raghav Awasthi
    2. Shreya Mishra
    3. Rachel Grasfield
    4. Julia Maslinski
    5. Dwarikanath Mahapatra
    6. Jacek B. Cywinski
    7. Ashish K. Khanna
    8. Kamal Maheshwari
    9. Chintan Dave
    10. Avneesh Khare
    11. Francis A. Papay
    12. Piyush Mathur

    Reviewed by PREreview

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  2. Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

    This article has 12 authors:
    1. Aleksandra Białas
    2. Thorsten Langner
    3. Adeline Harant
    4. Mauricio P Contreras
    5. Clare EM Stevenson
    6. David M Lawson
    7. Jan Sklenar
    8. Ronny Kellner
    9. Matthew J Moscou
    10. Ryohei Terauchi
    11. Mark J Banfield
    12. Sophien Kamoun
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      Convergent evolution is often observed in nature, but the molecular mechanisms allowing similar functions to independently emerge are rarely understood. This work determines how the high-affinity recognition of a pathogenic effector produced by the rice blast fungus, Avr-PikD, evolved in the immune receptor Pik-1. The integration of molecular evolution analyses with structure-function biochemical testing is novel to the field and the data quality is exceptional. In addition to advancing knowledge of host-microbe co-evolution, this work is exemplary in its transparency and the breadth of approaches utilized to understand protein evolution, and we expect that this study will provide a conceptual framework for similar studies in the future.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, PREreview

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity