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A list by Biophysics Colab

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  3. Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

    1. Márton A Simon
    2. Iordan Iordanov
    3. Andras Szollosi
    4. László Csanády

    • Curated by eLife

      eLife assessment

      This study uncovers a unique feature of the nucleotide binding domain interface in human CFTR, offering valuable insights into the effects of different non-hydrolytic mutations on CFTR gating. While the evidence presented is solid, a more thorough examination of the non-hydrolytic mutants of zebrafish CFTR for comparison would strengthen the authors' claims. In the current form, more cautious interpretations of some of the data are needed. This study will be of interest to researchers in the fields of cystic fibrosis and proteins in the ATP Binding Cassette (ABC) transporter family.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  4. A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

    1. Yiechang Lin
    2. Elaine Tao
    3. James P Champion
    4. Ben Corry

    • Curated by eLife

      eLife assessment

      This important study employs multiscale simulations to show that PIP2 lipids bind to DIV S4-S5 linkers within the inactivated state of a voltage-gated sodium channel, affecting the coupling of voltage sensors to the ion-conducting pore. The authors demonstrate that PIP2 prolongs inactivation by binding to the same site that binds the C-terminal during recovery from inactivation, and they suggest that binding to gating charges in the resting state may impede activation, both findings that contribute to our understanding of sodium channel modulation. The coarse-grained and atomistic molecular dynamics simulations are convincing, including state dependence and linker mutants to back up the claims.

    Reviewed by eLife

    10 evaluationsAppears in 2 listsLatest version Latest activity

  5. Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

    1. Omolade Otun
    2. Christelle Aljamous
    3. Elise Del Nero
    4. Marta Arimont-Segura
    5. Reggie Bosma
    6. Barbara Zarzycka
    7. Tristan Girbau
    8. Cédric Leyrat
    9. Chris de Graaf
    10. Rob Leurs
    11. Thierry Durroux
    12. Sebastien Granier
    13. Xiaojing Cong
    14. Cherine Bechara
    Appears in 1 listLatest version

  6. The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

    1. Marco van den Noort
    2. Panagiotis Drougkas
    3. Cristina Paulino
    4. Bert Poolman

    • Curated by eLife

      eLife assessment

      The OpuA Type I ABC importer uses two substrate binding domains to capture extracellular glycine betaine and present the substrate to the transmembrane domain for subsequent transport and correction of internal dehydration. This study presents valuable findings addressing the question of whether the two substrate binding domains of OpuA dock and physically interact in a salt-dependent manner. The single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy data that are presented provide convincing support for the existence of a transient interaction between the substrate binding domains that depends on ionic strength, laying a foundation for future studies exploring how this interaction is involved in the overall transport mechanism.

    Reviewed by eLife

    7 evaluationsAppears in 2 listsLatest version Latest activity

  8. Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3

    1. Aurelien M. Zarca
    2. Ilze Adlere
    3. Cristina P. Viciano
    4. Marta Arimont-Segura
    5. Max Meyrath
    6. Icaro A. Simon
    7. Jan Paul Bebelman
    8. Dennis Laan
    9. Hans G.J. Custers
    10. Elwin Janssen
    11. Kobus L. Versteegh
    12. Maurice C.M.L. Buzink
    13. Desislava N. Nesheva
    14. Reggie Bosma
    15. Iwan J.P. de Esch
    16. Henry F. Vischer
    17. Maikel Wijtmans
    18. Martyna Szpakowska
    19. Andy Chevigné
    20. Carsten Hoffmann
    21. Chris de Graaf
    22. Barbara A. Zarzycka
    23. Albert D. Windhorst
    24. Martine J. Smit
    25. Rob Leurs
    Appears in 1 listLatest version

  10. Structure of the human Duffy antigen receptor

    1. Shirsha Saha
    2. Basavraj Khanppnavar
    3. Jagannath Maharana
    4. Heeryung Kim
    5. Carlo Marion C. Carino
    6. Carole Daly
    7. Shane Houston
    8. Poonam Kumari
    9. Prem N. Yadav
    10. Bianca Plouffe
    11. Asuka Inoue
    12. Ka Young Chung
    13. Ramanuj Banerjee
    14. Volodymyr M. Korkhov
    15. Arun K. Shukla
    Appears in 1 listLatest version

  20. Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

    1. Jixing Lyu
    2. Tianqi Zhang
    3. Michael T Marty
    4. David Clemmer
    5. David H Russell
    6. Arthur Laganowsky

    • Curated by eLife

      eLife assessment

      This is an important biophysical study combining native mass spectrometry with mutant cycles to estimate the thermodynamic components of lipid A binding to the ABC transporter MsbA. Solid evidence supports the binding energies for lipid-protein interactions to MsbA using this approach, which could be later applied to other membrane proteins in general.

    Reviewed by eLife

    8 evaluationsAppears in 2 listsLatest version Latest activity
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