Reading List

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

1. Manish K. Yadav
2. Parishmita Sarma
3. Manisankar Ganguly
4. Sudha Mishra
5. Jagannath Maharana
6. Nashrah Zaidi
7. Annu Dalal
8. Vinay Singh
9. Sayantan Saha
10. Gargi Mahajan
11. Saloni Sharma
12. Mohamed Chami
13. Ramanuj Banerjee
14. Arun K. Shukla

Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

1. Guanxing Chen
2. Qin Li
3. Jiusheng Yan

• Curated by eLife

  eLife Assessment

  In this important contribution, Yan and colleagues describe a powerful and compelling strategy to generate concatamers of the BK channel and their fusion constructs with the auxiliary gamma subunits, which allows exploring contributions of individual subunits of the tetrameric channel to its gating and the study of heteromeric channel complexes of defined composition. Distinct examples are presented, which illustrate great diversity in the stoichiometric control of BK channel gating, depending on the site and nature of molecular perturbations. The molecular approaches could be extended to other membrane proteins whose N and C termini face opposite sides of the membrane.

Reviewed by eLife

Coarse-grained molecular dynamics simulations of lipid-protein interactions in SLC4 proteins

1. Hristina R. Zhekova
2. Daniel P. Ramirez-Echemendía
3. Besian I. Sejdiu
4. Alexander Pushkin
5. D. Peter Tieleman
6. Ira Kurtz

Protein engineering, production, reconstitution in lipid nanoparticles, and initial characterization of the Mycobacterium tuberculosis EfpA drug exporter

1. Olamide Ishola
2. Adeyemi Ogunbowale
3. Md Majharul Islam
4. Elaheh Hadadianpour
5. Saman Majeed
6. Oluwatosin Adetuyi
7. Elka R. Georgieva

The essential inter-domain interaction between NUDT9H and channel domain of human TRPM2 is also accomplished in trans

1. Wiebke Ehrlich
2. Frank J.P. Kühn

Stability of Alternative Bacteriorhodopsin Folds

1. Kristine A. Mackin
2. Douglas L. Theobald

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

1. Jaroslava Seflova
2. Jacob A. Schwarz
3. Abigail N. Smith
4. Bengt Svensson
5. Daniel J. Blackwell
6. Taylor A. Phillips
7. Roman Nikolaienko
8. Elisa Bovo
9. Robyn T. Rebbeck
10. Aleksey V. Zima
11. David D. Thomas
12. Filip Van Petegem
13. Björn C. Knollmann
14. Jeffrey N. Johnston
15. Seth L. Robia
16. Răzvan L. Cornea

Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1

1. Nitesh Kumar Khandelwal
2. Thomas M. Tomasiak

Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity

1. Yuhan Jiang
2. Zhen Li
3. Dexin Sui
4. Gaurav Sharma
5. Tianqi Wang
6. Keith MacRenaris
7. Hideki Takahashi
8. Kenneth Merz
9. Jian Hu

Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization

1. Lucas J. Handlin
2. Gucan Dai

Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations

1. Aylin Bircan
2. Nurdan Kuru
3. Onur Dereli
4. Berkay Selçuk
5. Ogün Adebali

Reviewed by Review Commons

Structural study of membrane proteins using vesicles

1. Hang Liu
2. Shangyu Dang

Combined Computational–Biochemical Approach Offers an Accelerated Path to Membrane Protein Solubilization

1. Mariah R. Pierce
2. Jingjing Ji
3. Sadie X. Novak
4. Michelle A. Sieburg
5. Shivangi Nangia
6. Shikha Nangia
7. James L. Hougland

The mitochondrial calcium uniporter transports Ca ²⁺ via a ligand-relay mechanism

1. Connie Chan
2. Chen-Ching Yuan
3. Jason G. McCoy
4. Patrick S. Ward
5. Zenon Grabarek

Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor

1. John Cowgill
2. Chen Fan
3. Nandan Haloi
4. Victor Tobiasson
5. Yuxuan Zhuang
6. Rebecca J. Howard
7. Erik Lindahl

The principles of peptide selection by the transporter associated with antigen processing

1. James Lee
2. Michael L. Oldham
3. Victor Manon
4. Jue Chen

Mechanism of negative μ -opioid receptor modulation by sodium ions

1. Neil J. Thomson
2. Ulrich Zachariae

Structure of mechanically activated ion channel OSCA2.3 reveals mobile elements in the transmembrane domain

1. Sebastian Jojoa-Cruz
2. Batuujin Burendei
3. Wen-Hsin Lee
4. Andrew B. Ward

Structure Reveals Homology in Elevator Transporters

1. Noah Trebesch
2. Emad Tajkhorshid

Extracellular cysteine disulfide bond break at Cys122 disrupts PIP ₂ -dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome

1. Francisco M. Cruz
2. Álvaro Macías
3. Ana I. Moreno-Manuel
4. Lilian K. Gutiérrez
5. María Linarejos Vera-Pedrosa
6. Isabel Martínez-Carrascoso
7. Patricia Sánchez Pérez
8. Juan Manuel Ruiz Robles
9. Francisco J Bermúdez-Jiménez
10. Aitor Díaz-Agustín
11. Fernando Martínez de Benito
12. Salvador Arias Santiago
13. Aitana Braza-Boils
14. Mercedes Martín-Martínez
15. Marta Gutierrez-Rodríguez
16. Juan A. Bernal
17. Esther Zorio
18. Juan Jiménez-Jaimez
19. José Jalife