Reading List

Chloride intracellular channel (CLIC) proteins function as fusogens

1. Bar Manori
2. Alisa Vaknin
3. Pavla Vaňková
4. Anat Nitzan
5. Ronen Zaidel-Bar
6. Petr Man
7. Moshe Giladi
8. Yoni Haitin

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain

1. Jennifer M. Kefauver
2. Markku Hakala
3. Luoming Zou
4. Josephine Alba
5. Javier Espadas
6. Maria G. Tettamanti
7. Jelena Gajić
8. Caroline Gabus
9. Pablo Campomanes
10. Leandro F. Estrozi
11. Nesli E. Sen
12. Stefano Vanni
13. Aurélien Roux
14. Ambroise Desfosses
15. Robbie Loewith

Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures

1. Jonathan Lasham
2. Amina Djurabekova
3. Volker Zickermann
4. Janet Vonck
5. Vivek Sharma

Observing Mechanosensitive Channels in Action in Living Bacteria

1. Mohammad Sharifian Gh.
2. Michael J. Wilhelm
3. Hai-Lung Dai

Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms

1. Louis Tung Faat Lai
2. Jayashree Balaraman
3. Fei Zhou
4. Doreen Matthies

Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

1. Deborah H Brotherton
2. Sarbjit Nijjar
3. Christos G Savva
4. Nicholas Dale
5. Alexander David Cameron

• Curated by eLife

  eLife assessment

  This study presents valuable new structures of a carbamylation-mimetic K125E mutant of the Cx26 gap junction channel uncovering the cytoplasmic loop structure and information about the closed state of the channel. The cryo-EM maps are in high quality and serve as strong foundations for dissecting the gating mechanism by CO2, providing convincing evidence in support of a mechanism where CO2-mediated carbamylation of Lys125 shifts the conformational equilibrium towards a state where the N-terminus occludes the pore of the channel. This information will be of interest to biochemists, cell biologists and biophysicists interested in the function of gap-junction channels in health and disease.

Reviewed by eLife

Switching Gō-Martini for Investigating Protein Conformational Transitions and Associated Protein-Lipid Interactions

1. Song Yang
2. Chen Song

Investigating the Effect of GLU283 Protonation State on the Conformational Heterogeneity of CCR5 by Molecular Dynamics Simulations

1. Berna Dogan
2. Serdar Durdağı

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

1. Chiara Mancinelli
2. Dagan C. Marx
3. Alberto J. Gonzalez-Hernandez
4. Kevin Huynh
5. Lucia Mancinelli
6. Anisul Arefin
7. George Khelashvilli
8. Joshua Levitz
9. David Eliezer

Structure of C. elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction

1. Sarah Clark
2. Hanbin Jeong
3. Rich Posert
4. April Goehring
5. Eric Gouaux

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

1. Verena Burtscher
2. Jonathan Mount
3. Jian Huang
4. John Cowgill
5. Yongchang Chang
6. Kathleen Bickel
7. Jianhan Chen
8. Peng Yuan
9. Baron Chanda

Predicting Relative Populations of Protein Conformations without a Physics Engine Using AlphaFold2

1. Gabriel Monteiro da Silva
2. Jennifer Y Cui
3. David C Dalgarno
4. George P Lisi
5. Brenda M Rubenstein

Reviewed by PREreview

Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization

1. Alexa Strauss
2. Alberto J. Gonzalez-Hernandez
3. Joon Lee
4. Nohely Abreu
5. Purushotham Selvakumar
6. Leslie Salas-Estrada
7. Melanie Kristt
8. Dagan C. Marx
9. Kristen Gilliland
10. Bruce J. Melancon
11. Marta Filizola
12. Joel Meyerson
13. Joshua Levitz

CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

1. Mengyuan Xu
2. Torben Neelands
3. Alexander S Powers
4. Yan Liu
5. Steven D Miller
6. Grigore D Pintilie
7. J Du Bois
8. Ron O Dror
9. Wah Chiu
10. Merritt Maduke

• Curated by eLife

  eLife assessment

  This study examines the human voltage-gated chloride channel CLC-2. A combination of cryo-EM, electrophysiology, and computational analysis provides compelling support for a "ball and chain" mechanism of inactivation. This and other findings regarding the gating and inhibition mechanisms of the channel are of fundamental interest to ion channel physiologists.

Reviewed by eLife

Insertases scramble lipids: Molecular simulations of MTCH2

1. Ladislav Bartoš
2. Anant K. Menon
3. Robert Vácha

An ancestral dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes

1. Augustinas Silale
2. Yiling Zhu
3. Jerzy Witwinowski
4. Robert E. Smith
5. Kahlan E. Newman
6. Satya P. Bhamidimarri
7. Arnaud Baslé
8. Syma Khalid
9. Christophe Beloin
10. Simonetta Gribaldo
11. Bert van den Berg

Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family

1. Rachael M. Lucero
2. Kemal Demirer
3. Trevor Justin Yeh
4. Randy B. Stockbridge

Searching deeply into the conformational space of glycoprotein hormone receptors. Molecular dynamics of the human follitropin and lutropin receptors within a bilayer of (SDPC) poly-unsaturated lipids

1. Eduardo Jardón-Valadez
2. Alfredo Ulloa-Aguirre

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes

1. Alex J. Timmis
2. Felix Cross
3. Danai S. Gkotsi
4. Hattie Ollerton
5. Colin A. Johnson
6. Natalia A. Riobo-Del Galdo

Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site

1. Jae Won Roh
2. Heon Yung Gee
3. Brian Wainger
4. Woo Kyung Kim
5. Wook Lee
6. Joo Hyun Nam