Reading List

Functional dissection of KATP channel structures reveals the importance of a conserved interface

1. Yaxiong Yang
2. Lei Chen

ArreSTick Motif is Responsible for GPCR-β-Arrestin Binding Stability and Extends Phosphorylation-Dependent β-arrestin Interactions to Non-Receptor Proteins

1. András Dávid Tóth
2. Eszter Soltész-Katona
3. Katalin Kis
4. Viktor Guti
5. Sharon Gilzer
6. Susanne Prokop
7. Roxána Boros
8. Ádám Misák
9. András Balla
10. Péter Várnai
11. Lilla Turiák
12. András Ács
13. László Drahos
14. Asuka Inoue
15. László Hunyady
16. Gábor Turu

A unified molecular theory of sweet taste: revisit, update and beyond

1. Bo Liu

Niclosamide potentiates TMEM16A and induces vasoconstriction

1. Pengfei Liang
2. Yui Chun S. Wan
3. Kuai Yu
4. H. Criss Hartzell
5. Huanghe Yang

Mitochondrial Ca ²⁺ uniporter (MCU) variants form plasma-membrane channels

1. Iuliia Polina
2. Jyotsna Mishra
3. Michael W Cypress
4. Maria Landherr
5. Nedyalka Valkov
6. Isabel Chaput
7. Bridget Nieto
8. Ulrike Mende
9. Peng Zhang
10. Bong Sook Jhun
11. Jin O-Uchi

Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding

1. Paweł P. Knejski
2. Satchal K. Erramilli
3. Anthony A. Kossiakoff

A new paradigm of intracrine free fatty acid receptor 4 signaling at lipid droplets

1. Emma Tripp
2. Shannon L. O’Brien
3. Gabrielle Smith
4. Adam Boufersaoui
5. Jennie Roberts
6. Jeremy Pike
7. Joao Correia
8. Tamara Miljus
9. Daniel A. Tennant
10. Brian D. Hudson
11. Graeme Milligan
12. Zachary Gerhart-Hines
13. Thue W. Schwartz
14. Davide Calebiro

The Molecular Mechanism of Positive Allosteric Modulation at the Dopamine D1 Receptor

1. Alexander Goldberg
2. Bing Xie
3. Lei Shi

YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition

1. Mai Ikei
2. Ryoji Miyazaki
3. Keigo Monden
4. Yusuke Naito
5. Azusa Takeuchi
6. Yutaro S. Takahashi
7. Yoshiki Tanaka
8. Keina Murata
9. Takaharu Mori
10. Muneyoshi Ichikawa
11. Tomoya Tsukazaki

Reviewed by Review Commons

Structural mapping of patient-associated KCNMA1 gene variants

1. Hans J. Moldenhauer
2. Kelly Tammen
3. Andrea L. Meredith

Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms

1. Reham Abdelaziz
2. Adam P Tomczak
3. Andreas Neef
4. Luis A Pardo

• Curated by eLife

  eLife assessment

  This valuable study examines the role of the interaction between cytoplasmic N- and C-terminal domains in voltage-dependent gating of Kv10.1 channels. The authors suggest that they have identified a hidden open state in Kv10.1 mutant channels, thus providing a window for observing early conformational transitions associated with channel gating. The evidence supporting the major conclusions is solid, but additional work is required to determine the molecular mechanism underlying the observations in this study. Learning the molecular mechanisms could be significant in understanding the gating mechanisms of the KCNH family and will appeal to biophysicists interested in ion channels and physiologists interested in cancer biology.

Reviewed by eLife

Cryo-EM structure of cell-free synthesized human histamine H ₂ receptor coupled to heterotrimeric G _s protein in lipid nanodisc environment

1. Zoe Köck
2. Kilian Schnelle
3. Margherita Persechino
4. Simon Umbach
5. Hannes Schihada
6. Dovile Januliene
7. Kristian Parey
8. Steffen Pockes
9. Peter Kolb
10. Volker Dötsch
11. Arne Möller
12. Daniel Hilger
13. Frank Bernhard

Reviewed by PREreview

Cell migration dynamics explained by the coupling of mechanics with electrochemistry and pH regulation

1. Yizeng Li
2. Sean X. Sun

Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors

1. Tyler W. McCullock
2. Loren P. Cardani
3. Paul J. Kammermeier

Ion selectivity and activation mechanism for kalium channelrhodopsins

1. Mingfeng Zhang
2. Yuanyue Shan
3. Liping Zhao
4. Xiao Li
5. Duanqing Pei

Structural insights into complex I deficiency and assembly from the disease-related ndufs4 ^-/- mouse

1. Zhan Yin
2. Ahmed-Noor A. Agip
3. Hannah R. Bridges
4. Judy Hirst

Phospholamban Inhibits the Cardiac Calcium Pump Through Reversing the Allosteric Enhancement of Calcium Affinity by ATP

1. Sean R. Cleary
2. Jaroslava Seflova
3. Ellen E. Cho
4. Konark Bisht
5. Himanshu Khandelia
6. L. Michel Espinoza-Fonseca
7. Seth L. Robia

Unraveling membrane protein localization and stabilization in nanodiscs

1. So-Jung Kim
2. Young Hoon Koh
3. Soung-Hun Roh

Functional regulation of aquaporin dynamics by lipid bilayer composition

1. Anh T. P. Nguyen
2. Austin T. Weigle
3. Diwakar Shukla

Coevolution-Driven Method for Efficiently Simulating Conformational Changes in Proteins Reveals Molecular Details of Ligand Effects in the β2AR Receptor

1. Darko Mitrovic
2. Yue Chen
3. Antoni Marciniak
4. Lucie Delemotte