Linkers in Bitopic Agonists Shape Bias Profile among Transducers for the Dopamine D2 and D3 Receptors

Ana Semeano
Rian Garland
Alessandro Bonifazi
Kuo Hao Lee
John Famiglietti
Wenqi Zhang
Yoon Jae Jo
Francisco O. Battiti
Lei Shi
Amy Hauck Newman
Hideaki Yano

Read the full article

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

Reading List (BiophysicsColab)

Log in to save this article

Abstract

No abstract available

Version published to 10.1021/acsptsci.4c00119
Jul 26, 2024
Version published to 10.1101/2024.01.07.574547 on bioRxiv
Jan 8, 2024

Structural Basis of Ligand-Specific Orthosteric-Allosteric Coupling and Sensory Tuning in the Human Bitter Taste Receptor TAS2R14

This article has 9 authors:
1. Tao Zhou
2. Jiening Wang
3. Chulun Wang
4. Zhen Han
5. Yi Zhang
6. Zishao Ouyang
7. Sheng Ye
8. Shan Wu
9. Anna Qiao
This article has no evaluationsLatest version May 17, 2026
Coordinated subpocket engagement underlies nitazene potency at the µ-opioid receptor

This article has 5 authors:
1. Margaret Jane Robinson
2. Li Chen
3. Abhishek Thakur
4. Kuo-Hao Lee
5. Lei Shi
This article has no evaluationsLatest version Apr 29, 2026
Buprenorphine Restricts the Conformational Landscape of the μ-Opioid Receptor

This article has 5 authors:
1. Simone Aureli
2. Maria Bzowka
3. Nicola Piasentin
4. Massimo Fuss
5. Francesco Luigi Gervasio
This article has no evaluationsLatest version Jun 16, 2026