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A list by Biophysics Colab

Articles that are being read by Biophysics Colab.

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  1. Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

    1. Michael J Currie
    2. James S Davies
    3. Mariafrancesca Scalise
    4. Ashutosh Gulati
    5. Joshua D Wright
    6. Michael C Newton-Vesty
    7. Gayan S Abeysekera
    8. Ramaswamy Subramanian
    9. Weixiao Y Wahlgren
    10. Rosmarie Friemann
    11. Jane R Allison
    12. Peter D Mace
    13. Michael DW Griffin
    14. Borries Demeler
    15. Soichi Wakatsuki
    16. David Drew
    17. Cesare Indiveri
    18. Renwick CJ Dobson
    19. Rachel A North

    • Curated by eLife

      eLife assessment

      The current manuscript presents a cryo-EM structure of a tripartite ATP-independent periplasmic (TRAP) transporter that contributes to Haemophilus influenzae virulence. Convincing biophysical and cryo-EM experiments yield a valuable molecular model, but the functional importance of some of the molecular features identified remains to be demonstrated.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity

  3. Divergent folding-mediated epistasis among unstable membrane protein variants

    1. Laura M Chamness
    2. Charles P Kuntz
    3. Andrew G McKee
    4. Wesley D Penn
    5. Christopher M Hemmerich
    6. Douglas B Rusch
    7. Hope Woods
    8. Dyotima
    9. Jens Meiler
    10. Jonathan P Schlebach

    • Curated by eLife

      eLife assessment

      This important study describes exhaustive deep mutational scanning (DMS) of the gonadotropin-releasing hormone wild-type receptor and for two single point mutations that impact its folding and structure, monitoring how plasma membrane expression levels are influenced by the introduced mutations. With solid evidence, the authors have pioneered an exploration of the interaction between mutations (epistasis) in a membrane protein, with a potential for explaining membrane protein evolution and genetic diseases.

    Reviewed by eLife

    8 evaluationsAppears in 2 listsLatest version Latest activity

  6. Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain

    1. Jennifer M. Kefauver
    2. Markku Hakala
    3. Luoming Zou
    4. Josephine Alba
    5. Javier Espadas
    6. Maria G. Tettamanti
    7. Jelena Gajić
    8. Caroline Gabus
    9. Pablo Campomanes
    10. Leandro F. Estrozi
    11. Nesli E. Sen
    12. Stefano Vanni
    13. Aurélien Roux
    14. Ambroise Desfosses
    15. Robbie Loewith
    Appears in 1 listLatest version

  10. Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

    1. Deborah H Brotherton
    2. Sarbjit Nijjar
    3. Christos G Savva
    4. Nicholas Dale
    5. Alexander David Cameron

    • Curated by eLife

      eLife assessment

      This study presents valuable new structures of a carbamylation-mimetic K125E mutant of the Cx26 gap junction channel uncovering the cytoplasmic loop structure and information about the closed state of the channel. The cryo-EM maps are in high quality and serve as strong foundations for dissecting the gating mechanism by CO2, providing convincing evidence in support of a mechanism where CO2-mediated carbamylation of Lys125 shifts the conformational equilibrium towards a state where the N-terminus occludes the pore of the channel. This information will be of interest to biochemists, cell biologists and biophysicists interested in the function of gap-junction channels in health and disease.

    Reviewed by eLife

    9 evaluationsAppears in 2 listsLatest version Latest activity

  18. CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism

    1. Mengyuan Xu
    2. Torben Neelands
    3. Alexander S Powers
    4. Yan Liu
    5. Steven D Miller
    6. Grigore D Pintilie
    7. J Du Bois
    8. Ron O Dror
    9. Wah Chiu
    10. Merritt Maduke

    • Curated by eLife

      eLife assessment

      This study examines the human voltage-gated chloride channel CLC-2. A combination of cryo-EM, electrophysiology, and computational analysis provides compelling support for a "ball and chain" mechanism of inactivation. This and other findings regarding the gating and inhibition mechanisms of the channel are of fundamental interest to ion channel physiologists.

    Reviewed by eLife

    9 evaluationsAppears in 3 listsLatest version Latest activity
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