Reading List

A Cell-Permeable Nanobody to Restore F508del Cystic Fibrosis Transmembrane Conductance Regulator Activity

1. Luise Franz
2. Tihomir Rubil
3. Anita Balázs
4. Marie Overtus
5. Kristin Kemnitz-Hassanin
6. Cedric Govaerts
7. Marcus A. Mall
8. Christian P.R. Hackenberger

Automated collective variable discovery for MFSD2A transporter from molecular dynamics simulations

1. Myongin Oh
2. Margarida Rosa
3. Hengyi Xie
4. George Khelashvili

Cholesterol Dependence of the Conformational Changes in Metabotropic Glutamate Receptor 1

1. Ugochi H. Isu
2. Shadi A. Badiee
3. Adithya Polasa
4. Seyed H. Tabari
5. Mortaza Derakhshani-Molayousefi
6. Mahmoud Moradi

Coupling the role of lipids to the conformational dynamics of the ABC transporter P-glycoprotein

1. Dario De Vecchis
2. Lars V. Schäfer

Effect of two activators on the gating of a K _2P channel

1. Edward Mendez-Otalvaro
2. Wojciech Kopec
3. Bert L. de Groot

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger

1. Sandipan Chowdhury
2. Kamalendu Pal

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

1. Iqra Sohail
2. Suli-Anne Laurin
3. Gunnar Kleinau
4. Vidicha Chunilal
5. Andrew Morton
6. Alfonso Brenlla-Lopez
7. Zeynep Cansu Uretmen Kagiali
8. Javier A. Tello
9. Annette G. Beck-Sickinger
10. Marie-José Blouin
11. Martin J. Lohse
12. Patrick Scheerer
13. Michel Bouvier
14. Peter McCormick
15. Paolo Annibale
16. Heike Biebermann

Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy

1. Alexandra C. Schwartz
2. Richard A. Stein
3. Eva Gil-Iturbe
4. Matthias Quick
5. Hassane S. Mchaourab

Exploring the influence of pore shape on conductance and permeation

1. David Seiferth
2. Philip C. Biggin

Lipid-dependent conformational dynamics of bacterial ATP-binding cassette transporter Sav1866

1. Shadi A Badiee
2. Jeevapani Hettige
3. Mahmoud Moradi

Multiresolution molecular dynamics simulations reveal the interplay between conformational variability and functional interactions in membrane-bound cytochrome 2B4

1. Sungho Bosco Han
2. Jonathan Teuffel
3. Goutam Mukherjee
4. Rebecca C. Wade

Molecular basis of proton sensing by G protein-coupled receptors

1. Matthew K. Howard
2. Nicholas Hoppe
3. Xi-Ping Huang
4. Darko Mitrovic
5. Christian B. Billesbølle
6. Christian B. Macdonald
7. Eshan Mehrotra
8. Patrick Rockefeller Grimes
9. Donovan D. Trinidad
10. Lucie Delemotte
11. Justin G. English
12. Willow Coyote-Maestas
13. Aashish Manglik

Bi-directional allosteric pathway in NMDA receptor activation and modulation

1. Paula A. Bender
2. Subhajit Chakraborty
3. Ryan J. Durham
4. Vladimir Berka
5. Elisa Carrillo
6. Vasanthi Jayaraman

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

1. Xiaolong Hu
2. Weizhen Ao
3. Mingxin Gao
4. Lijie Wu
5. Yuan Pei
6. Shenhui Liu
7. Qianqian Sun
8. Junlin Liu
9. Longquan Jiang
10. Yiran Wu
11. Xin Wang
12. Yan Li
13. Qiwen Tan
14. Jie Cheng
15. Fan Yang
16. Chi Yang
17. Jinpeng Sun
18. Tian Hua
19. Zhi-Jie Liu

Structural and Dynamic Insights into the Biased Signaling Mechanism of the Human Kappa Opioid Receptor

1. Chiyo Suno-Ikeda
2. Ryo Nishikawa
3. Riko Suzuki
4. Seiya Iwata
5. Tomoyo Takai
6. Takaya Ogura
7. Mika Hirose
8. Akitoshi Inoue
9. Eri Asai
10. Ryoji Kise
11. Yukihiko Sugita
12. Takayuki Kato
13. Hiroshi Nagase
14. Tsuyoshi Saitoh
15. Kota Katayama
16. Asuka Inoue
17. Hideki Kandori
18. Takuya Kobayashi
19. Ryoji Suno

Aquaporin 10 paralogs exhibit evolutionarily altered urea and boric acid permeabilities based on the amino acid residues at positions 1 and 3 in the ar/R region

1. Ayumi Nagashima
2. Kazutaka Ushio
3. Hidenori Nishihara
4. Jin Akimoto
5. Akira Kato
6. Tadaomi Furuta

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

1. Parveen Goyal
2. KanagaVijayan Dhanabalan
3. Mariafrancesca Scalise
4. Rosmarie Friemann
5. Cesare Indiveri
6. Renwick CJ Dobson
7. Kutti R Vinothkumar
8. Subramanian Ramaswamy

• Curated by eLife

  eLife Assessment

  This valuable work provides novel insights into the substrate binding mechanism of a tripartite ATP-independent periplasmic (TRAP) transporter, which may be helpful for the development of specific inhibitors. The structural analysis is convincing, but additional work will be required to establish the transport mechanism as well as well as binding sites for all ligands. This study will be of interest to the membrane transport and bacterial biochemistry communities.

Reviewed by eLife

Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG

1. Eri Hirata
2. Ken-taro Sakata
3. Grace I. Dearden
4. Faria Noor
5. Indu Menon
6. George N. Chiduza
7. Anant K. Menon

Positive allosteric modulation of a GPCR ternary complex

1. Wessel A. C. Burger
2. Christopher J. Draper-Joyce
3. Celine Valant
4. Arthur Christopoulos
5. David M. Thal

Structural insights into the human P2X1 receptor and ligand interactions

1. Felix M. Bennetts
2. Hariprasad Venugopal
3. Alisa Glukhova
4. Jesse I. Mobbs
5. Sabatino Ventura
6. David M. Thal