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A list by Biophysics Colab

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  3. Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function

    1. Rizki Tsari Andriani
    2. Tanadet Pipatpolkai
    3. Haruhiko Miyata
    4. Masahito Ikawa
    5. Yasushi Okamura
    6. Takafumi Kawai

    • Curated by eLife

      eLife Assessment

      This study presents a useful contribution to understanding zinc regulation of sperm physiology, specifically its inhibitory effects on the sperm-specific potassium channel Slo3. However, the evidence supporting the claims is incomplete, as critical experimental controls are lacking, key mechanistic aspects remain insufficiently explored, and experimental descriptions are often inadequate, making it difficult to fully assess the findings. Strengthening the study with additional electrophysiological recordings in sperm cells, improved imaging controls, and clearer methodological descriptions would enhance its impact and rigor.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  6. Structure and Cl- Conductance Properties of the Open State of Human CFTR

    1. Zhi-Wei Zeng
    2. Christopher E Ing
    3. Régis Pomès

    • Curated by eLife

      eLife Assessment

      This important study reports a detailed computational analysis of the CFTR ion channel's permeation mechanism, advancing our understanding of its structure-function relationship. The conclusions are based on extensive molecular dynamics simulations and thorough analysis, but the use of an approximate chloride ion model, known to underestimate key ion-protein interactions, leaves them incomplete without experimental or alternative computational validation. The work will be of interest to biophysicists working on CFTR and cystic fibrosis.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  8. Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    1. Jing Xue
    2. Weizhong Zeng
    3. Scott John
    4. Nicole Attiq
    5. Michela Ottolia
    6. Youxing Jiang

    • Curated by eLife

      eLife Assessment

      Cardiac Ca2+/Na+ exchange is mediated by the NCX1 antiporter, whose activity is tightly regulated. This important manuscript describes the structural basis of activation by the lipid DiC8-PIP2 and inhibition by binding of a small molecule to NCX1. These results provide convincing insights into NCX1 regulation and the structural basis of cellular Ca2+ signaling.

    Reviewed by eLife

    8 evaluationsAppears in 2 listsLatest version Latest activity

  16. AER-270 and TGN-020 are not aquaporin-4 water channel blockers

    1. Lucas Unger
    2. Kim Wagner
    3. Jonas H Steffen
    4. Malene Lykke Wind
    5. Tamim Al-Jubair
    6. Hongjun Zou
    7. Charlotte Clarke-Bland
    8. Rebecca Murray
    9. Bareerah Qureshi
    10. Susanna Lundström
    11. Massimiliano Gaetani
    12. David Poyner
    13. Hoor Ayub
    14. Mark Wheatley
    15. Pontus Gourdon
    16. Andrea J Yool
    17. Susanna Törnroth-Horsefield
    18. Roslyn M Bill
    19. Mootaz M. Salman
    20. Philip Kitchen
    Appears in 1 listLatest version

  17. The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine

    1. Lyubomyr Burtnyak
    2. Yifeng Yuan
    3. Erwina Stojek
    4. Xiaobei Pan
    5. Lankani Gunaratne
    6. Gabriel Silveira d’Almeida
    7. Claire Fergus
    8. Maria Martinelli
    9. Colbie J. Reed
    10. Jessie Fernandez
    11. Bhargesh Indravadan Patel
    12. Isaac Marquez
    13. Ann E. Ehrenhofer-Murray
    14. Manal A. Swairjo
    15. Juan D. Alfonzo
    16. Brian D. Green
    17. Vincent P. Kelly
    18. Valérie de Crécy-Lagard
    Appears in 1 listLatest version
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