Reading List

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

1. Shirsha Saha
2. Fumiya K. Sano
3. Saloni Sharma
4. Manisankar Ganguly
5. Sayantan Saha
6. Hiroaki Akasaka
7. Takaaki Kobayashi
8. Nashrah Zaidi
9. Sudha Mishra
10. Annu Dalal
11. Samanwita Mohapatra
12. Manish K. Yadav
13. Yuzuru Itoh
14. Rob Leurs
15. Andy Chevigné
16. Ramanuj Banerjee
17. Wataru Shihoya
18. Osamu Nureki
19. Arun K. Shukla

Insights on the GPCR helix 8 solution structure and orientation using a neurotensin receptor 1 peptide

1. James B. Bower
2. Scott A. Robson
3. Joshua J. Ziarek

Cryo-EM structures of human cone visual pigments

1. Qi Peng
2. Jian Li
3. Haihai Jiang
4. Xinyu Cheng
5. Qiuyuan Lu
6. Sili Zhou
7. Yuting Zhang
8. Sijia Lv
9. Shuangyan Wan
10. Tingting Yang
11. Yixiang Chen
12. Wei Zhang
13. Weiwei Nan
14. Tong Che
15. Yanyan Li
16. Hongfei Liao
17. Jin Zhang

Harnessing AlphaFold to reveal hERG channel conformational state secrets

1. Khoa Ngo
2. Pei-Chi Yang
3. Vladimir Yarov-Yarovoy
4. Colleen E Clancy
5. Igor Vorobyov

• Curated by eLife

  eLife Assessment

  This valuable study uses AlphaFold2 to guide the structural modelling of different states of the human voltage-gated potassium channel KV11.1, a key pharmacological drug target. Follow-up molecular dynamics and drug-docking simulations, combined with experimental characterization, offer convincing evidence supporting the models. The work shows potential for improving drug potency predictions in ion channel pharmacology.

Reviewed by eLife

Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels

1. Swastik Phulera
2. Callum J. Dickson
3. Christopher J. Schwalen
4. Maryam Khoshouei
5. Samantha J. Cassell
6. Yishan Sun
7. Tara Condos
8. Jonathan Whicher
9. Wilhelm A. Weihofen

Constitutive sodium permeability in a C. elegans two-pore domain potassium channel

1. O Andrini
2. I Ben Soussia
3. P Tardy
4. DS Walker
5. C Peña-Varas
6. D Ramírez
7. M Gendrel
8. M Mercier
9. S El Mouridi
10. A Leclercq-Blondel
11. W González
12. WR Schafer
13. M Jospin
14. T Boulin

On the lipid dependence of bacterial mechanosensitive channel gating in situ

1. Madolyn Britt
2. Katsuhiro Sawasato
3. Elissa Moller
4. Gerald Kidd
5. Mikhail Bogdanov
6. Sergei Sukharev

Conformational changes of the ABC Transporter BmrA Depend on Membrane Curvature

1. Alicia Damm
2. Su-Jin Paik
3. Raj Kumar Sadhu
4. Aurélie Di-Cicco
5. John Manzi
6. Michele Castellana
7. Emmanuel Margeat
8. Maxime Dahan
9. Pierre Sens
10. Daniel Lévy
11. Patricia Bassereau

Polymer-extracted structure of the mechanosensitive channel MscS reveals the role of protein-lipid interactions in the gating cycle

1. Elissa Moller
2. Madolyn Britt
3. Fei Zhou
4. Hyojik Yang
5. Andriy Anshkin
6. Robert Ernst
7. Sergei Sukharev
8. Doreen Matthies

They all rock: A systematic comparison of conformational movements in LeuT-fold transporters

1. Jacob A. Licht
2. Samuel P. Berry
3. Michael A. Gutierrez
4. Rachelle Gaudet

ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins

1. Chloe Hicks
2. Julia Gardner
3. Dylan Scott Eiger
4. Nicholas D. Camarda
5. Uyen Pham
6. Saisha Dhar
7. Hailey Rodriguez
8. Anand Chundi
9. Sudarshan Rajagopal

Molecular mechanism of β-arrestin-2 interaction with phosphatidylinositol 4,5-bisphosphate

1. Kiae Kim
2. Ka Young Chung

Freestanding bilayer microscope for single-molecule imaging of membrane proteins

1. Gonzalo Pérez-Mitta
2. Yeliz Sezgin
3. Weiwei Wang
4. Roderick MacKinnon

Structure of the extracellular region of the adhesion GPCR CELSR1 reveals a compact module which regulates G protein-coupling

1. Sumit J. Bandekar
2. Krassimira Garbett
3. Szymon P. Kordon
4. Ethan Dintzner
5. Tanner Shearer
6. Richard C. Sando
7. Demet Araç

Different fluorescent labels report distinct components of spHCN channel voltage sensor movement

1. Magdalena N Wojciechowski
2. Chaseley E McKenzie
3. Andrew Hung
4. Alibek Kuanyshbek
5. Ming S Soh
6. Christopher A Reid
7. Ian C Forster

Divergent mechanisms of steroid inhibition in the human ρ1 GABA _A receptor

1. Chen Fan
2. John Cowgill
3. Rebecca J. Howard
4. Erik Lindahl

Reviewed by PREreview

Identification of a binding site for small molecule inhibitors targeting human TRPM4

1. Babatunde Ekundayo
2. Prakash Arullampalam
3. Christian E. Gerber
4. Anne-Flore Hämmerli
5. Sabrina Guichard
6. Mey Boukenna
7. Daniela Ross-Kaschitza
8. Martin Lochner
9. Jean-Sebastien Rougier
10. Henning Stahlberg
11. Hugues Abriel
12. Dongchun Ni

Understanding and Predicting Ligand Efficacy in the μ-Opioid Receptor through Quantitative Dynamical Analysis of Complex Structures

1. Gabriel T. Galdino
2. Olivier Mailhot
3. Rafael Najmanovich

Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens

1. Yuzhu Z. Wang
2. Koki Natsume
3. Tatsuki Tanaka
4. Shoko Hososhima
5. Rintaro Tashiro
6. Fumiya K. Sano
7. Hiroaki Akasaka
8. Satoshi P. Tsunoda
9. Wataru Shihoya
10. Hideki Kandori
11. Osamu Nureki

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP

1. Hongtao Liu
2. Dariusz Zakrzewicz
3. Kamil Nosol
4. Rossitza N. Irobalieva
5. Somnath Mukherjee
6. Rose Bang-Sørensen
7. Nora Goldmann
8. Sebastian Kunz
9. Lorenzo Rossi
10. Anthony A. Kossiakoff
11. Stephan Urban
12. Dieter Glebe
13. Joachim Geyer
14. Kaspar P. Locher